{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:38:51Z","timestamp":1770892731237,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"am","delay-in-days":346,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014148","name":"Centro Hospitalar Universitario de Santo Antonio","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Research"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.eplepsyres.2024.107478","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T08:05:32Z","timestamp":1731053132000},"page":"107478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["MicroRNAs as potential biomarkers of response to modified Atkins diet in treatment of adults with drug-resistant epilepsy: A proof-of-concept study"],"prefix":"10.1016","volume":"208","author":[{"given":"Raquel","family":"Sam\u00f5es","sequence":"first","affiliation":[]},{"given":"Ana","family":"Cavalheiro","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Catarina","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"Maria Manuel","family":"Tavares","sequence":"additional","affiliation":[]},{"given":"Cl\u00e1udia","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Carolina","family":"Lemos","sequence":"additional","affiliation":[]},{"given":"Paulo Pinho","family":"e Costa","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Cavaco","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Chaves","sequence":"additional","affiliation":[]},{"given":"B\u00e1rbara","family":"Leal","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.eplepsyres.2024.107478_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/nu16101401","article-title":"Ketogenic diet induced shifts in the gut microbiome associate with changes to inflammatory cytokines and brain-related mirnas in children with autism spectrum disorder","volume":"16","author":"Allan","year":"2024","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.eplepsyres.2024.107478_bib2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13041-020-00653-x","article-title":"Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice","volume":"13","author":"Almeida Silva","year":"2020","journal-title":"Mol. Brain"},{"issue":"6","key":"10.1016\/j.eplepsyres.2024.107478_bib3","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1460-9568.2010.07122.x","article-title":"Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy","volume":"31","author":"Aronica","year":"2010","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.eplepsyres.2024.107478_bib4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1474-4422(17)30408-8","article-title":"Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders","volume":"17","author":"Augustin","year":"2018","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.eplepsyres.2024.107478_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173060","article-title":"MicroRNA hsa-miR-134 is a circulating biomarker for mesial temporal lobe epilepsy","volume":"12","author":"Avansini","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.eplepsyres.2024.107478_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/WCO.0000000000000432","article-title":"New insights into the mechanisms of the ketogenic diet","volume":"30","author":"Boison","year":"2017","journal-title":"Curr. Opin. Neurol."},{"issue":"9","key":"10.1016\/j.eplepsyres.2024.107478_bib7","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s41582-020-0369-8","article-title":"MicroRNAs as regulators of brain function and targets for treatment of epilepsy","volume":"16","author":"Brennan","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.eplepsyres.2024.107478_bib8","doi-asserted-by":"crossref","first-page":"1230942","DOI":"10.3389\/fnmol.2023.1230942","article-title":"Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy","volume":"16","author":"Brindley","year":"2023","journal-title":"Front Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.eplepsyres.2024.107478_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2174\/2211536611666220510111711","article-title":"Diet and miRNA: Epigenetic Regulator or a New Class of Supplements?","volume":"11","author":"Cannataro","year":"2022","journal-title":"Microrna"},{"issue":"2","key":"10.1016\/j.eplepsyres.2024.107478_bib10","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2174\/2211536608666181126093903","article-title":"Ketogenic Diet Acts on Body Remodeling and MicroRNAs Expression Profile","volume":"8","author":"Cannataro","year":"2019","journal-title":"Microrna"},{"issue":"8","key":"10.1016\/j.eplepsyres.2024.107478_bib11","article-title":"Ketogenic Diet and microRNAs Linked to Antioxidant Biochemical Homeostasis","volume":"8","author":"Cannataro","year":"2019","journal-title":"Antioxid. (Basel)"},{"issue":"4","key":"10.1016\/j.eplepsyres.2024.107478_bib12","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/epi.17513","article-title":"A core outcome set for childhood epilepsy treated with ketogenic diet therapy (CORE-KDT study): International parent and health professional consensus","volume":"64","author":"Carroll","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2024.107478_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.yebeh.2016.02.038","article-title":"Establishing an Adult Epilepsy Diet Center: Experience, efficacy and challenges","volume":"58","author":"Cervenka","year":"2016","journal-title":"Epilepsy Behav."},{"issue":"5","key":"10.1016\/j.eplepsyres.2024.107478_bib14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1212\/CPJ.0000000000001007","article-title":"International Recommendations for the Management of Adults Treated With Ketogenic Diet Therapies","volume":"11","author":"Cervenka","year":"2021","journal-title":"Neurol. Clin. Pr."},{"issue":"6","key":"10.1016\/j.eplepsyres.2024.107478_bib15","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/epi.17583","article-title":"The need for an individualized approach to what is considered a clinically significant reduction in seizure frequency: A patient's perspective","volume":"64","author":"van der Kop","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.eplepsyres.2024.107478_bib16","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2018.3711","article-title":"MicroRNA\u2011155 contributes to the occurrence of epilepsy through the PI3K\/Akt\/mTOR signaling pathway","author":"Duan","year":"2018","journal-title":"Int J. Mol. Med 42(3): 1577-1584."},{"issue":"4","key":"10.1016\/j.eplepsyres.2024.107478_bib17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/epi4.12275","article-title":"Discovery and validation of blood microRNAs as molecular biomarkers of epilepsy: Ways to close current knowledge gaps","volume":"3","author":"Enright","year":"2018","journal-title":"Epilepsia Open"},{"issue":"4","key":"10.1016\/j.eplepsyres.2024.107478_bib18","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s00415-019-09658-6","article-title":"Effectiveness, retention, and safety of modified ketogenic diet in adults with epilepsy at a tertiary-care centre in the UK","volume":"267","author":"Green","year":"2020","journal-title":"J. Neurol."},{"key":"10.1016\/j.eplepsyres.2024.107478_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.910662","article-title":"Mesial Temporal Lobe Epilepsy (MTLE) Drug-Refractoriness Is Associated With P2X7 Receptors Overexpression in the Human Hippocampus and Temporal Neocortex and May Be Predicted by Low Circulating Levels of miR-22","volume":"16","author":"Guerra Leal","year":"2022","journal-title":"Front Cell Neurosci."},{"issue":"4","key":"10.1016\/j.eplepsyres.2024.107478_bib20","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3233\/JAD-170343","article-title":"A 9-microRNA Signature in Serum Serves as a Noninvasive Biomarker in Early Diagnosis of Alzheimer's Disease","volume":"60","author":"Guo","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.eplepsyres.2024.107478_bib21","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3233\/JAD-210307","article-title":"Novel Plasma miRNAs as Biomarkers and Therapeutic Targets of Alzheimer's Disease at the Prodromal Stage","volume":"83","author":"He","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"11","key":"10.1016\/j.eplepsyres.2024.107478_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e21098","article-title":"\u03b2-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications","volume":"9","author":"He","year":"2023","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.eplepsyres.2024.107478_bib23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1080\/21655979.2021.2015528","article-title":"Relationships between plasma expression levels of microRNA-146a and microRNA-132 in epileptic patients and their cognitive, mental and psychological disorders","volume":"13","author":"Huang","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.eplepsyres.2024.107478_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2020.106319","article-title":"The ketogenic diet all grown up-Ketogenic diet therapies for adults","volume":"162","author":"Husari","year":"2020","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.eplepsyres.2024.107478_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2020.106454","article-title":"Ketogenic diet and Neuroinflammation","volume":"167","author":"Koh","year":"2020","journal-title":"Epilepsy Res"},{"issue":"2","key":"10.1016\/j.eplepsyres.2024.107478_bib26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/epi4.12225","article-title":"Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group","volume":"3","author":"Kossoff","year":"2018","journal-title":"Epilepsia Open"},{"issue":"6","key":"10.1016\/j.eplepsyres.2024.107478_bib27","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.eplepsyres.2024.107478_bib28","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/epi.16502","article-title":"Circulating miR-146a and miR-134 in predicting drug-resistant epilepsy in patients with focal impaired awareness seizures","volume":"61","author":"Leontariti","year":"2020","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.eplepsyres.2024.107478_bib29","first-page":"543","article-title":"miR\u2011146a improves hepatic lipid and glucose metabolism by targeting MED1","volume":"45","author":"Li","year":"2020","journal-title":"Int J. Mol. Med"},{"issue":"4","key":"10.1016\/j.eplepsyres.2024.107478_bib30","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/ene.14129","article-title":"Circulating microRNAs as potential biomarkers for genetic generalized epilepsies: a three microRNA panel","volume":"27","author":"Martins-Ferreira","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.eplepsyres.2024.107478_bib31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.seizure.2018.06.019","article-title":"Improving compliance in adults with epilepsy on a modified Atkins diet: A randomized trial","volume":"60","author":"McDonald","year":"2018","journal-title":"Seizure"},{"key":"10.1016\/j.eplepsyres.2024.107478_bib32","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ebiom.2019.07.008","article-title":"Targeting microRNA-134 for seizure control and disease modification in epilepsy","volume":"45","author":"Morris","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.eplepsyres.2024.107478_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2020.106444","article-title":"Ketogenic diet, neuroprotection, and antiepileptogenesis","volume":"167","author":"Murugan","year":"2020","journal-title":"Epilepsy Res"},{"issue":"2","key":"10.1016\/j.eplepsyres.2024.107478_bib34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12031-013-9953-3","article-title":"Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy","volume":"50","author":"Peng","year":"2013","journal-title":"J. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.eplepsyres.2024.107478_bib35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12967-017-1248-y","article-title":"Identification of clear cell renal cell carcinoma and oncocytoma using a three-gene promoter methylation panel","volume":"15","author":"Pires-Lu\u00eds","year":"2017","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.eplepsyres.2024.107478_bib36","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-022-02769-8","article-title":"Roles of the miR-155 in Neuroinflammation and Neurological Disorders: A Potent Biological and Therapeutic Target","author":"Rastegar-Moghaddam","year":"2022","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.eplepsyres.2024.107478_bib37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.yebeh.2018.12.010","article-title":"Modified ketogenic diets in adults with refractory epilepsy: Efficacious improvements in seizure frequency, seizure severity, and quality of life","volume":"93","author":"Roehl","year":"2019","journal-title":"Epilepsy Behav."},{"issue":"1","key":"10.1016\/j.eplepsyres.2024.107478_bib38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.31083\/j.jin2101031","article-title":"Transcriptomic profile of epileptic children treated with ketogenic therapies","volume":"21","author":"Ruiz-Herrero","year":"2022","journal-title":"J. Integr. Neurosci."},{"issue":"4","key":"10.1016\/j.eplepsyres.2024.107478_bib39","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"issue":"1-2","key":"10.1016\/j.eplepsyres.2024.107478_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2013.06.002","article-title":"Can we predict a favourable response to Ketogenic Diet Therapies for drug-resistant epilepsy?","volume":"106","author":"Schoeler","year":"2013","journal-title":"Epilepsy Res"},{"issue":"15","key":"10.1016\/j.eplepsyres.2024.107478_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/nu14153245","article-title":"Epigenome Modulation Induced by Ketogenic Diets","volume":"14","author":"Ungaro","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.eplepsyres.2024.107478_bib42","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/08830185.2017.1281272","article-title":"MicroRNA-22-3p as a novel regulator and therapeutic target for autoimmune diseases","volume":"36","author":"Wang","year":"2017","journal-title":"Int Rev. Immunol."},{"issue":"12","key":"10.1016\/j.eplepsyres.2024.107478_bib43","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.3899\/jrheum.100308","article-title":"Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus","volume":"37","author":"Wang","year":"2010","journal-title":"J. Rheuma"},{"issue":"3","key":"10.1016\/j.eplepsyres.2024.107478_bib44","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2174\/156652412799218886","article-title":"Emerging roles of microRNA-22 in human disease and normal physiology","volume":"12","author":"Xiong","year":"2012","journal-title":"Curr. Mol. Med"}],"container-title":["Epilepsy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121124001931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0920121124001931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:34:20Z","timestamp":1762317260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0920121124001931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":44,"alternative-id":["S0920121124001931"],"URL":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2024.107478","relation":{},"ISSN":["0920-1211"],"issn-type":[{"value":"0920-1211","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNAs as potential biomarkers of response to modified Atkins diet in treatment of adults with drug-resistant epilepsy: A proof-of-concept study","name":"articletitle","label":"Article Title"},{"value":"Epilepsy Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eplepsyres.2024.107478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107478"}}