{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:38:39Z","timestamp":1772829519863,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Laboratory for Process Engineering, Environment, Biotechnology and Energy \u2013 LEPABE","award":["POCI-01-0145-FEDER-006939"],"award-info":[{"award-number":["POCI-01-0145-FEDER-006939"]}]},{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Programa Operacional Competitividade e Internacionaliza\u00e7\u00e3o (POCI)"},{"name":"FCT - Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"name":"FCT"},{"name":"Portuguese Government and the Social European","award":["SFRH\/BD\/76900\/2011"],"award-info":[{"award-number":["SFRH\/BD\/76900\/2011"]}]},{"name":"Portuguese Government and the Social European","award":["SFRH\/BPD\/85462\/2012"],"award-info":[{"award-number":["SFRH\/BPD\/85462\/2012"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.fct.2016.09.019","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T14:32:05Z","timestamp":1474036325000},"page":"277-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Ptaquiloside from bracken (Pteridium spp.) inhibits tumour-infiltrating CD8+ T cells in HPV-16 transgenic mice"],"prefix":"10.1016","volume":"97","author":[{"given":"Carlos","family":"Santos","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Ferreirinha","sequence":"additional","affiliation":[]},{"given":"Hugo","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Margarida M.S.M.","family":"Bastos","sequence":"additional","affiliation":[]},{"given":"Tiago","family":"Neto","sequence":"additional","affiliation":[]},{"given":"Paula A.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Vilanova","sequence":"additional","affiliation":[]},{"given":"Rui M.","family":"Gil da Costa","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2016.09.019_bib1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.2174\/0929867023370743","article-title":"Human carcinogenesis and bracken fern: a review of the evidence","volume":"9","author":"Alonso-Amelot","year":"2002","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.fct.2016.09.019_bib2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jchromb.2014.01.022","article-title":"Determination of ptaquiloside and pterosin B derived from bracken (Pteridium aquilinum) in cattle plasma, urine and milk","volume":"951\u2013952","author":"Aranha","year":"2014","journal-title":"J.\u00a0Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.fct.2016.09.019_bib3","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1128\/jvi.68.7.4358-4368.1994","article-title":"Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice","volume":"68","author":"Arbeit","year":"1994","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.fct.2016.09.019_bib4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ijc.29683","article-title":"CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: a multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG)","volume":"138","author":"Balermpas","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.fct.2016.09.019_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-1759(03)00265-5","article-title":"Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation","volume":"281","author":"Betts","year":"2003","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.fct.2016.09.019_bib6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jcpa.2006.01.001","article-title":"Urinary bladder lesions in bovine enzootic haematuria","volume":"134","author":"Carvalho","year":"2006","journal-title":"J.\u00a0Comp. Pathol."},{"key":"10.1016\/j.fct.2016.09.019_bib7","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/00365529209000119","article-title":"Human papillomavirus involvement in esophageal precancerous lesions and squamous cell carcinomas as evidenced by microscopy and different DNA techniques","volume":"27","author":"Chang","year":"1992","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.fct.2016.09.019_bib8","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/etc.2533","article-title":"The naturally occurring carcinogen ptaquiloside is present in groundwater below bracken vegetation","volume":"33","author":"Clauson-Kaas","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.fct.2016.09.019_bib9","first-page":"1899","article-title":"Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice","volume":"149","author":"Coussens","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fct.2016.09.019_bib10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ccr.2005.04.014","article-title":"De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent","volume":"7","author":"de Visser","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.fct.2016.09.019_bib11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.immunol.22.012703.104803","article-title":"The three Es of cancer immunoediting","volume":"22","author":"Dunn","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fct.2016.09.019_bib12","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/208913a0","article-title":"Carcinogenic activity of bracken","volume":"208","author":"Evans","year":"1965","journal-title":"Nature"},{"key":"10.1016\/j.fct.2016.09.019_bib13","doi-asserted-by":"crossref","first-page":"8518","DOI":"10.1021\/jf201342t","article-title":"Residue potential of norsesquiterpene glycosides in tissues of cattle fed Austral bracken (Pteridium esculentum)","volume":"59","author":"Fletcher","year":"2011","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.fct.2016.09.019_bib14","series-title":"New Developments in Terpenes Research","first-page":"135","article-title":"Illudane-type sesquiterpenes: challenges and opportunities for toxicology and chemotherapy","author":"Gil da Costa","year":"2014"},{"key":"10.1016\/j.fct.2016.09.019_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jhazmat.2011.12.046","article-title":"Bracken-associated human and animal health hazards: chemical, biological and pathological evidence","volume":"203\u2013204","author":"Gil da Costa","year":"2012","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.fct.2016.09.019_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mrgentox.2012.04.010","article-title":"Multiple genotoxic activities of ptaquiloside in human lymphocytes: aneugenesis, clastogenesis and induction of sister chromatid exchange","volume":"747","author":"Gil da Costa","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2016.09.019_bib17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00705-013-1801-9","article-title":"Bovine papillomavirus: opening new trends for comparative pathology","volume":"159","author":"Gil da Costa","year":"2014","journal-title":"Arch. Virol."},{"key":"10.1016\/j.fct.2016.09.019_bib18","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/tox.21803","article-title":"Ptaquiloside-induced early-stage urothelial lesions show increased cell proliferation and intact beta-catenin and E-cadherin expression","volume":"29","author":"Gil da Costa","year":"2014","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.fct.2016.09.019_bib19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.toxicon.2011.08.016","article-title":"Ptaquiloside-induced, B-cell lymphoproliferative and early-stage urothelial lesions in mice","volume":"58","author":"Gil da Costa","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.fct.2016.09.019_bib20","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1038\/ncomms6317","article-title":"Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients","volume":"5","author":"Kim","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fct.2016.09.019_bib21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tox.2012.12.010","article-title":"Ptaquiloside reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium","volume":"304","author":"Latorre","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2016.09.019_bib22","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.fct.2010.11.026","article-title":"Selenium reverses Pteridium aquilinum-induced immunotoxic effects","volume":"49","author":"Latorre","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2016.09.019_bib23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1080\/15476910902972465","article-title":"Immunomodulatory effects of Pteridium aquilinum on natural killer cell activity and select aspects of the cellular immune response of mice","volume":"6","author":"Latorre","year":"2009","journal-title":"J.\u00a0Immunotoxicol."},{"key":"10.1016\/j.fct.2016.09.019_bib24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5586\/asbp.2012.046","article-title":"Food uses of ferns in China: a review","volume":"81","author":"Liu","year":"2012","journal-title":"Acta Soc. Bot. Pol."},{"key":"10.1016\/j.fct.2016.09.019_bib25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jcpa.2010.11.002","article-title":"A\u00a0retrospective study of 586 tumours in Brazilian cattle","volume":"145","author":"Lucena","year":"2011","journal-title":"J.\u00a0Comp. Pathol."},{"key":"10.1016\/j.fct.2016.09.019_bib26","first-page":"189","article-title":"Human papillomavirus infections: new perspectives for prevention and treatment","volume":"30","author":"Menzo","year":"2007","journal-title":"New Microbiol."},{"key":"10.1016\/j.fct.2016.09.019_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.0105-2896.2006.00382.x","article-title":"Signals required for programming effector and memory development by CD8+ T cells","volume":"211","author":"Mescher","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fct.2016.09.019_bib28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.immuni.2010.01.003","article-title":"An activation marker finds a function","volume":"32","author":"Mitchell","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.fct.2016.09.019_bib29","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1016\/S0040-4039(00)88276-3","article-title":"Ptaquiloside, a novel norsesquiterpene glucoside from Bracken, Pteridium aquilinum var. latiusculum","volume":"24","author":"Niwa","year":"1983","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.fct.2016.09.019_bib30","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/bjc.2015.277","article-title":"Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma","volume":"113","author":"Oguejiofor","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.fct.2016.09.019_bib31","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1021\/np50040a019","article-title":"Studies on Pteridium aquilinum var. latiusculum, IV. Isolation of three p-hydroxystyrene glycosides and an efficient method for the isolation of ptaquiloside, an unstable bracken carcinogen","volume":"48","author":"Ojika","year":"1985","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.fct.2016.09.019_bib32","doi-asserted-by":"crossref","first-page":"e0116868","DOI":"10.1371\/journal.pone.0116868","article-title":"A\u00a0role for MicroRNA-155 expression in microenvironment associated to HPV-induced carcinogenesis in K14-HPV16 transgenic mice","volume":"10","author":"Paiva","year":"2015","journal-title":"PLoS one"},{"key":"10.1016\/j.fct.2016.09.019_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lfs.2015.02.020","article-title":"MicroRNA-21 expression and susceptibility to HPV-induced carcinogenesis - role of microenvironment in K14-HPV16 mice model","volume":"128","author":"Paiva","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2016.09.019_bib34","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1084\/jem.173.5.1099","article-title":"Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes","volume":"173","author":"Peters","year":"1991","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.fct.2016.09.019_bib35","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.oraloncology.2013.12.019","article-title":"Epidemiology of HPV-associated oropharyngeal cancer","volume":"50","author":"Pytynia","year":"2014","journal-title":"Oral Oncol."},{"key":"10.1016\/j.fct.2016.09.019_bib36","first-page":"258","article-title":"Land management of bracken needs to account for bracken carcinogens\u2013a case study from Britain","volume":"151","author":"Rasmussen","year":"2015","journal-title":"J.\u00a0Environ. Manag."},{"key":"10.1016\/j.fct.2016.09.019_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-4614-6217-0_9","article-title":"Memory CD8(+) T cell protection","volume":"785","author":"Remakus","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.fct.2016.09.019_bib38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.lfs.2016.05.040","article-title":"Celecoxib promotes degranulation of CD8(+) T cells in HPV-induced lesions of K14-HPV16 transgenic mice","volume":"157","author":"Santos","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2016.09.019_bib39","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/jnci\/djq562","article-title":"Human papillomavirus testing in the prevention of cervical cancer","volume":"103","author":"Schiffman","year":"2011","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.fct.2016.09.019_bib40","first-page":"1294","article-title":"Cross-species comparison of angiogenesis during the premalignant stages of squamous carcinogenesis in the human cervix and K14-HPV16 transgenic mice","volume":"57","author":"Smith-McCune","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2016.09.019_bib41","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.ejca.2015.04.024","article-title":"A\u00a0model for predicting clinical outcome in patients with human papillomavirus-positive tonsillar and base of tongue cancer","volume":"51","author":"Tertipis","year":"2015","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.fct.2016.09.019_bib42","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nri911","article-title":"Functional significance of the perforin\/granzyme cell death pathway","volume":"2","author":"Trapani","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fct.2016.09.019_bib43","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fimmu.2014.00182","article-title":"Understanding MHC class I presentation of viral antigens by human dendritic cells as a basis for rational design of therapeutic vaccines","volume":"5","author":"van Montfoort","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fct.2016.09.019_bib44","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1476-4598-10-140","article-title":"Papillomavirus E5: the smallest oncoprotein with many functions","volume":"10","author":"Venuti","year":"2011","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.fct.2016.09.019_bib45","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1021\/acs.jafc.5b01937","article-title":"Ptaquiloside, the major carcinogen of bracken fern, in the pooled raw milk of healthy sheep and goats: an underestimated, global concern of food safety","volume":"63","author":"Virgilio","year":"2015","journal-title":"J.\u00a0Agric. Food Chem."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516303349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691516303349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:31:19Z","timestamp":1759527079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691516303349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":45,"alternative-id":["S0278691516303349"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2016.09.019","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ptaquiloside from bracken (Pteridium spp.) inhibits tumour-infiltrating CD8+ T cells in HPV-16 transgenic mice","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2016.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}