{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:25:54Z","timestamp":1776270354915,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"name":"QOPNA"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food Chemistry"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.foodchem.2014.01.106","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T05:31:31Z","timestamp":1391751091000},"page":"204-211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Assessment of the antioxidant and antiproliferative effects of sesquiterpenic compounds in in vitro Caco-2 cell models"],"prefix":"10.1016","volume":"156","author":[{"given":"Juliana","family":"Vinholes","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Martel","sequence":"additional","affiliation":[]},{"given":"Manuel A.","family":"Coimbra","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia M.","family":"Rocha","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.foodchem.2014.01.106_b0005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q","article-title":"Antioxidant activity of Nigella sativa essential oil","volume":"14","author":"Burits","year":"2000","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.foodchem.2014.01.106_b0010","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.foodchem.2011.06.016","article-title":"Chemical composition, in vitro cytotoxic and antioxidant activities of the essential oil and major constituents of Cymbopogon jawarancusa (Kashmir)","volume":"129","author":"Dar","year":"2011","journal-title":"Food Chemistry"},{"key":"10.1016\/j.foodchem.2014.01.106_b0015","doi-asserted-by":"crossref","first-page":"6636","DOI":"10.1021\/jf901162f","article-title":"Protective effects of the essential oil of Salvia fruticosa and its constituents on astrocytic susceptibility to hydrogen peroxide-induced cell death","volume":"57","author":"Elmann","year":"2009","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.foodchem.2014.01.106_b0020","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.foodchem.2008.01.009","article-title":"Influence of anthocyanins and derivative pigments from blueberry (Vaccinium myrtillus) extracts on MPP+ intestinal uptake: A structure\u2013activity approach","volume":"109","author":"Faria","year":"2008","journal-title":"Food Chemistry"},{"key":"10.1016\/j.foodchem.2014.01.106_b0025","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/ptr.3213","article-title":"Blueberry anthocyanins and pyruvic acid adducts: Anticancer properties in breast cancer cell lines","volume":"24","author":"Faria","year":"2010","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.foodchem.2014.01.106_b0030","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tiv.2011.11.009","article-title":"Nerolidol effects on mitochondrial and cellular energetics","volume":"26","author":"Ferreira","year":"2012","journal-title":"Toxicology in Vitro"},{"key":"10.1016\/j.foodchem.2014.01.106_b0035","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00280-010-1418-6","article-title":"Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs","volume":"67","author":"Fr\u00f6mberg","year":"2011","journal-title":"Cancer Chemotherapy and Pharmacology"},{"key":"10.1016\/j.foodchem.2014.01.106_b0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mrgentox.2011.03.010","article-title":"Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains","volume":"723","author":"Gon\u00e7alves","year":"2011","journal-title":"Mutation Research \u2013 Genetic Toxicology and Environmental Mutagenesis"},{"key":"10.1016\/j.foodchem.2014.01.106_b0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cbi.2011.03.009","article-title":"Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats","volume":"192","author":"Khan","year":"2011","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.foodchem.2014.01.106_b0050","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ardp.19973300103","article-title":"Effect of guaiazulene on some cytochrome P450 activities. Implication in the metabolic activation and hepatotoxicity of paracetamol","volume":"330","author":"Kourounakis","year":"1997","journal-title":"Archiv der Pharmazie"},{"key":"10.1016\/j.foodchem.2014.01.106_b0055","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.2042-7158.1997.tb06140.x","article-title":"Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats","volume":"49","author":"Kourounakis","year":"1997","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.foodchem.2014.01.106_b0060","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/jnr.20692","article-title":"Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia","volume":"82","author":"Lim","year":"2005","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.foodchem.2014.01.106_b0065","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.foodchem.2007.07.070","article-title":"Organic acids influence on DPPH scavenging by ascorbic acid","volume":"107","author":"Lo Scalzo","year":"2008","journal-title":"Food Chemistry"},{"key":"10.1016\/j.foodchem.2014.01.106_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2012.12.027","article-title":"In vitro antioxidant activities of polysaccharides extracted from Moso Bamboo-Leaf","volume":"55","author":"Mao","year":"2013","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.foodchem.2014.01.106_b0075","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/jn\/129.4.804","article-title":"Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids","volume":"129","author":"Mo","year":"1999","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.foodchem.2014.01.106_b0080","series-title":"Nutritional oncology","first-page":"629","article-title":"Isoprenoids and novel inhibitors of mevalonate pathway activities","author":"Mo","year":"2006"},{"key":"10.1016\/j.foodchem.2014.01.106_b0085","series-title":"Nutritional oncology","first-page":"379","article-title":"Targeting the action of isoprenoids and related phytochemicals to tumors","author":"Mo","year":"1999"},{"key":"10.1016\/j.foodchem.2014.01.106_b0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"Journal of Immunological Methods"},{"key":"10.1016\/j.foodchem.2014.01.106_b0095","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2133\/dmpk.21.230","article-title":"Ischemia\/reperfusion injury in the monolayers of human intestinal epithelial cell line Caco-2 and its recovery by antioxidants","volume":"21","author":"Nagira","year":"2006","journal-title":"Drug Metabolism and Pharmacokinetics"},{"key":"10.1016\/j.foodchem.2014.01.106_b0100","series-title":"Antioxidant enzyme","first-page":"381","article-title":"Assay guided comparison for enzymatic and non-enzymatic antioxidant activities with special reference to medicinal plants","author":"Panda","year":"2012"},{"key":"10.1016\/j.foodchem.2014.01.106_b0105","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0002-9343(00)00547-7","article-title":"Oxidative injury in diseases of the central nervous system: focus on Alzheimer\u2019s disease","volume":"109","author":"Pratic\u00f2","year":"2000","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.foodchem.2014.01.106_b0110","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cbi.2008.08.011","article-title":"Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: An initial step in lung chemoprevention","volume":"176","author":"Qamar","year":"2008","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.foodchem.2014.01.106_b0115","series-title":"Recent progress in medicinal plants","first-page":"253","article-title":"Grapes and wine from Vitis vinifera L. as a potential source of sesquiterpenoids","author":"Rocha","year":"2006"},{"key":"10.1016\/j.foodchem.2014.01.106_b0120","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0308-8146(99)00247-2","article-title":"Antioxidant activity of selected essential oil components in two lipid model systems","volume":"69","author":"Ruberto","year":"2000","journal-title":"Food Chemistry"},{"key":"10.1016\/j.foodchem.2014.01.106_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10565-005-0085-6","article-title":"The Caco-2 cell line as a model of the intestinal barrier: Influence of cell and culture-related factors on Caco-2 cell functional characteristics","volume":"21","author":"Sambuy","year":"2005","journal-title":"Cell Biology and Toxicology"},{"key":"10.1016\/j.foodchem.2014.01.106_b0130","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1590\/S0044-59672008000100012","article-title":"Cytotoxic evaluation of essential oil from Casearia sylvestris Sw on human cancer cells and erythrocytes","volume":"38","author":"Silva","year":"2008","journal-title":"Acta Amazonica"},{"key":"10.1016\/j.foodchem.2014.01.106_b0135","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/0031-9422(89)80182-7","article-title":"Hydroxyl radical scavenging activity of compatible solutes","volume":"28","author":"Smirnoff","year":"1989","journal-title":"Phytochemistry"},{"key":"10.1016\/j.foodchem.2014.01.106_b0140","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/jn\/134.5.1105","article-title":"Cold-storage affects antioxidant properties of apples in Caco-2 Cells","volume":"134","author":"Tarozzi","year":"2004","journal-title":"The Journal of Nutrition"},{"key":"10.1016\/j.foodchem.2014.01.106_b0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3835(01)00723-6","article-title":"Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells","volume":"175","author":"Tatman","year":"2002","journal-title":"Cancer Letters"},{"key":"10.1016\/j.foodchem.2014.01.106_b0165","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.foodchem.2013.09.039","article-title":"Hepatoprotection of sesquiterpenoids: a quantitative structure-activity relationship (QSAR) approach","volume":"146","author":"Vinholes","year":"2014","journal-title":"Food Chemistry"},{"key":"10.1016\/j.foodchem.2014.01.106_b0155","first-page":"4747","article-title":"Cytotoxic activity of azulenes against human oral tumor cell lines","volume":"23","author":"Wakabayash","year":"2003","journal-title":"Anticancer Research"},{"key":"10.1016\/j.foodchem.2014.01.106_b0160","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.fct.2012.12.042","article-title":"The hepatoprotection of caffeic acid and rosmarinic acid, major compounds of Perilla frutescens, against t-BHP-induced oxidative liver damage","volume":"55","author":"Yang","year":"2013","journal-title":"Food Chemical Toxicology"}],"container-title":["Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0308814614001381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0308814614001381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T12:13:16Z","timestamp":1565179996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0308814614001381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":32,"alternative-id":["S0308814614001381"],"URL":"https:\/\/doi.org\/10.1016\/j.foodchem.2014.01.106","relation":{},"ISSN":["0308-8146"],"issn-type":[{"value":"0308-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of the antioxidant and antiproliferative effects of sesquiterpenic compounds in in vitro Caco-2 cell models","name":"articletitle","label":"Article Title"},{"value":"Food Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.foodchem.2014.01.106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}