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Rep."},{"key":"10.1016\/j.isci.2026.114733_bib75","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1093\/humrep\/dead177","article-title":"Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction","volume":"38","author":"Smits","year":"2023","journal-title":"Hum. 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Rev."},{"key":"10.1016\/j.isci.2026.114733_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116608","article-title":"Zigui-Yichong-Fang protects against cyclophosphamide-induced premature ovarian insufficiency via the SIRT1\/Foxo3a pathway","volume":"314","author":"Xiu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.isci.2026.114733_bib80","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41556-019-0287-4","article-title":"NAD(+) metabolism governs the proinflammatory senescence-associated secretome","volume":"21","author":"Nacarelli","year":"2019","journal-title":"Nat. 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