{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:52:08Z","timestamp":1791579128474,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017585","name":"The First Hospital of Jilin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017585","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Affective Disorders"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jad.2026.122604","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:24:21Z","timestamp":1791473061000},"page":"122604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiorespiratory fitness and risk of depression and anxiety: A prospective cohort study with proteomic profiling in the UK Biobank"],"prefix":"10.1016","author":[{"given":"Yuting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naifei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jad.2026.122604_bb0005","doi-asserted-by":"crossref","first-page":"166.e1","DOI":"10.1016\/j.ajog.2023.01.012","article-title":"Perinatal mood and anxiety disorders: biomarker discovery using plasma proteomics","volume":"229","author":"Accortt","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jad.2026.122604_bb0010","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1530\/REP-13-0486","article-title":"Insulin-like factor 3 as a monitor of endocrine disruption","volume":"147","author":"Anand-Ivell","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.jad.2026.122604_bb0015","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(17)30569-X","article-title":"Structural racism and health inequities in the USA: evidence and interventions","volume":"389","author":"Bailey","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jad.2026.122604_bb0020","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/bjsports-2024-108955","article-title":"Association of cardiorespiratory fitness with the incidence and progression trajectory of cardiometabolic multimorbidity","volume":"59","author":"Chen","year":"2025","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.jad.2026.122604_bb0025","doi-asserted-by":"crossref","first-page":"162","DOI":"10.7326\/0003-4819-158-3-201302050-00005","article-title":"The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study","volume":"158","author":"Defina","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jad.2026.122604_bb0030","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1249\/MSS.0000000000000506","article-title":"Decline in cardiorespiratory fitness and odds of incident sleep complaints","volume":"47","author":"Dishman","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.jad.2026.122604_bb0035","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1126\/science.aaq1327","article-title":"Co-regulatory networks of human serum proteins link genetics to disease","volume":"361","author":"Emilsson","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jad.2026.122604_bb0040","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1073\/pnas.1015950108","article-title":"Exercise training increases size of hippocampus and improves memory","volume":"108","author":"Erickson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jad.2026.122604_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/srep13588","article-title":"FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes","volume":"5","author":"Gan","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.122604_bb0050","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1038\/s41467-023-38013-7","article-title":"Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants","volume":"14","author":"Gao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jad.2026.122604_bb0055","doi-asserted-by":"crossref","first-page":"826","DOI":"10.2105\/AJPH.2004.060749","article-title":"\u201cWeathering\u201d and age patterns of allostatic load scores among blacks and whites in the United States","volume":"96","author":"Geronimus","year":"2006","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.jad.2026.122604_bb0060","doi-asserted-by":"crossref","first-page":"15315","DOI":"10.1038\/s41598-021-94768-3","article-title":"Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose-response relationships with disease outcomes","volume":"11","author":"Gonzales","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jad.2026.122604_bb0065","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s11886-023-01975-7","article-title":"Obesity, cardiorespiratory fitness, and cardiovascular disease","volume":"25","author":"Haidar","year":"2023","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.jad.2026.122604_bb0070","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/s12916-025-04175-y","article-title":"Cross-national differences in the association between estimated cardiorespiratory fitness and depressive symptoms among older adults: findings from three nationwide cohort studies","volume":"23","author":"He","year":"2025","journal-title":"BMC Med."},{"key":"10.1016\/j.jad.2026.122604_bb0075","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1186\/s12877-024-05311-8","article-title":"Global prevalence of depression, anxiety, and stress in the elderly population: a systematic review and meta-analysis","volume":"24","author":"Jalali","year":"2024","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.jad.2026.122604_bb0080","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.jad.2019.07.088","article-title":"The association between cardiorespiratory fitness and the incidence of common mental health disorders: a systematic review and meta-analysis","volume":"257","author":"Kandola","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122604_bb0085","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S2215-0366(20)30034-1","article-title":"Depressive symptoms and objectively measured physical activity and sedentary behaviour throughout adolescence: a prospective cohort study","volume":"7","author":"Kandola","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.jad.2026.122604_bb0090","article-title":"Associations between accurate measures of adiposity and fitness, blood proteins, and insulin sensitivity among South Asians and Europeans","volume":"15","author":"Kho","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jad.2026.122604_bb0095","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.mad.2005.10.004","article-title":"A new approach to the concept and computation of biological age","volume":"127","author":"Klemera","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.jad.2026.122604_bb0100","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1001\/jama.2009.681","article-title":"Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis","volume":"301","author":"Kodama","year":"2009","journal-title":"Jama"},{"key":"10.1016\/j.jad.2026.122604_bb0105","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4088\/JCP.10m06176blu","article-title":"Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA)","volume":"72","author":"Lamers","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jad.2026.122604_bb0110","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","article-title":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"9","year":"2022","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.jad.2026.122604_bb0115","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/j.cell.2025.03.005","article-title":"Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety","volume":"188","author":"Lee","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.jad.2026.122604_bb0120","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jad.2026.122604_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2024.03.135","article-title":"Accelerated biological aging as potential mediator mediates the relationship between pro-inflammatory diets and the risk of depression and anxiety: a prospective analysis from the UK Biobank","volume":"355","author":"Lin","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jad.2026.122604_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00052","article-title":"Exercise-mediated neurogenesis in the hippocampus via BDNF","volume":"12","author":"Liu","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jad.2026.122604_bb0135","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/mp.2014.114","article-title":"Vascular hippocampal plasticity after aerobic exercise in older adults","volume":"20","author":"Maass","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122604_bb0140","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa145","article-title":"A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder","volume":"2","author":"Maekawa","year":"2020","journal-title":"Brain Commun."},{"key":"10.1016\/j.jad.2026.122604_bb0145","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2014.10.051","article-title":"Maternal stress, nutrition and physical activity: impact on immune function, CNS development and psychopathology","volume":"1617","author":"Marques","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.jad.2026.122604_bb0150","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41380-018-0017-5","article-title":"Depression and obesity: evidence of shared biological mechanisms","volume":"24","author":"Milaneschi","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jad.2026.122604_bb0155","article-title":"Hypothalamic-pituitary-adrenal (HPA) axis: unveiling the potential mechanisms involved in stress-induced Alzheimer's disease and depression","volume":"16","author":"P","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.jad.2026.122604_bb0160","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s40279-015-0409-5","article-title":"Depression symptom severity and cardiorespiratory fitness in healthy and depressed adults: a systematic review and meta-analysis","volume":"46","author":"Papasavvas","year":"2016","journal-title":"Sports Med."},{"key":"10.1016\/j.jad.2026.122604_bb0165","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1186\/s12889-022-14457-2","article-title":"Changes in self-reported and accelerometer-measured physical activity among pregnant TRICARE beneficiaries","volume":"22","author":"Pebley","year":"2022","journal-title":"BMC Public Health"},{"issue":"Suppl. 2","key":"10.1016\/j.jad.2026.122604_bb0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/JAD-2011-102070","article-title":"Leptin induces proliferation of neuronal progenitors and neuroprotection in a mouse model of Alzheimer's disease","volume":"24","author":"P\u00e9rez-Gonz\u00e1lez","year":"2011","journal-title":"J. Alzheimer's Dis"},{"key":"10.1016\/j.jad.2026.122604_bb0175","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1479-5868-5-56","article-title":"A comparison of direct versus self-report measures for assessing physical activity in adults: a systematic review","volume":"5","author":"Prince","year":"2008","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"key":"10.1016\/j.jad.2026.122604_bb0180","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12967-025-06189-9","article-title":"Accelerated biological aging mediates the association between inflammatory markers with Helicobacter pylori infection and mortality","volume":"23","author":"Qiu","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jad.2026.122604_bb0185","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1001\/jamapediatrics.2022.5090","article-title":"Physical activity interventions to alleviate depressive symptoms in children and adolescents: a systematic review and meta-analysis","volume":"177","author":"Recchia","year":"2023","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.jad.2026.122604_bb0190","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1161\/CIR.0000000000000461","article-title":"Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American Heart Association","volume":"134","author":"Ross","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jad.2026.122604_bb0195","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41562-024-02078-1","article-title":"Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality","volume":"9","author":"Shen","year":"2025","journal-title":"Nat. Hum. Behav."},{"key":"10.1016\/j.jad.2026.122604_bb0200","article-title":"Too much is too little: estimating the optimal physical activity level for a healthy mental state","volume":"13","author":"Shimura","year":"2022","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jad.2026.122604_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.101907","article-title":"Atlas of exercise-induced brain activation in mice","volume":"82","author":"Skovbjerg","year":"2024","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jad.2026.122604_bb0210","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.15092","article-title":"Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body \u03b2-hydroxybutyrate","volume":"5","author":"Sleiman","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.jad.2026.122604_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med."},{"key":"10.1016\/j.jad.2026.122604_bb0220","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jad.2026.122604_bb0225","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41586-024-08108-2","article-title":"Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake","volume":"636","author":"Tan","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jad.2026.122604_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105781","article-title":"Mitochondrial function and A\u03b2 in Alzheimer's disease postmortem brain","volume":"171","author":"Troutwine","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jad.2026.122604_bb0235","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.arr.2018.10.002","article-title":"Exercise-induced brain-derived neurotrophic factor expression: therapeutic implications for Alzheimer's dementia","volume":"48","author":"Wang","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jad.2026.122604_bb0240","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s10865-008-9185-0","article-title":"Discrimination and racial disparities in health: evidence and needed research","volume":"32","author":"Williams","year":"2009","journal-title":"J. Behav. Med."},{"key":"10.1016\/j.jad.2026.122604_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217271","article-title":"FABP4-mediated lipid metabolism promotes TNBC progression and breast cancer stem cell activity","volume":"604","author":"Yu","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jad.2026.122604_bb0250","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1111\/jcmm.18000","article-title":"Oridonin attenuates atherosclerosis by inhibiting foam macrophage formation and inflammation through FABP4\/PPAR\u03b3 signalling","volume":"27","author":"Zhang","year":"2023","journal-title":"J. Cell. Mol. Med."}],"container-title":["Journal of Affective Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726014588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165032726014588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:36:47Z","timestamp":1791578207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165032726014588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":50,"alternative-id":["S0165032726014588"],"URL":"https:\/\/doi.org\/10.1016\/j.jad.2026.122604","relation":{},"ISSN":["0165-0327"],"issn-type":[{"value":"0165-0327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiorespiratory fitness and risk of depression and anxiety: A prospective cohort study with proteomic profiling in the UK Biobank","name":"articletitle","label":"Article Title"},{"value":"Journal of Affective Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jad.2026.122604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"122604"}}