{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:51:18Z","timestamp":1777265478912,"version":"3.51.4"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.jconrel.2023.09.027","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T06:55:31Z","timestamp":1695884131000},"page":"275-289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Exosome delivery to the testes for dmrt1 suppression: A powerful tool for sex-determining gene studies"],"prefix":"10.1016","volume":"363","author":[{"given":"Tengfei","family":"Zhu","sequence":"first","affiliation":[]},{"given":"Ming","family":"Kong","sequence":"additional","affiliation":[]},{"given":"Yingying","family":"Yu","sequence":"additional","affiliation":[]},{"given":"Manfred","family":"Schartl","sequence":"additional","affiliation":[]},{"given":"Deborah Mary","family":"Power","sequence":"additional","affiliation":[]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[]},{"given":"Wenxiu","family":"Ma","sequence":"additional","affiliation":[]},{"given":"Yanxu","family":"Sun","sequence":"additional","affiliation":[]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[]},{"given":"Bowen","family":"Yue","sequence":"additional","affiliation":[]},{"given":"Weijing","family":"Li","sequence":"additional","affiliation":[]},{"given":"Changwei","family":"Shao","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2023.09.027_bb0005","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science (80)"},{"key":"10.1016\/j.jconrel.2023.09.027_bb0010","article-title":"Application of exosomes as liquid biopsy in clinical diagnosis","volume":"5","author":"Zhou","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pharmthera.2017.02.020","article-title":"Exosomes: therapy delivery tools and biomarkers of diseases","volume":"174","author":"Barile","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0020","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.addr.2020.04.004","article-title":"Extracellular vesicles as drug delivery systems: why and how?","volume":"159","author":"Elsharkasy","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0025","first-page":"1","article-title":"Exosome biochemistry and advanced nanotechnology for next-generation theranostic platforms","volume":"31","author":"Yang","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0030","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jconrel.2020.07.042","article-title":"Mittal, surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: strategies and significance","volume":"326","author":"Salunkhe","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.09.027_bb0035","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biomaterials.2018.06.029","article-title":"NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo","volume":"178","author":"Jia","year":"2018","journal-title":"Biomaterials."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0040","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0045","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/d41573-020-00220-y","article-title":"Exosome-based candidates move into the clinic","volume":"20","author":"Cully","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0050","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1152\/physrev.00044.2019","article-title":"Sex determination, gonadal sex differentiation, and plasticity in vertebrate species","volume":"101","author":"Nagahama","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0055","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nrg3161","article-title":"Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity","volume":"13","author":"Matson","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0060","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/45130","article-title":"Conservation of a sex-determining gene","volume":"402","author":"Smith","year":"1999","journal-title":"Nature."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0065","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature751","article-title":"DMY is a Y-specific DM-domain gene required for male development in the medaka fish","volume":"417","author":"Matsuda","year":"2002","journal-title":"Nature."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0070","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1210\/en.2009-0999","article-title":"Doublesex- and Mab-3-related transcription factor-1 repression of aromatase transcription, a possible mechanism favoring the male pathway in Tilapia","volume":"151","author":"Wang","year":"2010","journal-title":"Endocrinology."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1534\/g3.111.000190","article-title":"An SNP-based linkage map for zebrafish reveals sex determination loci","volume":"1","author":"Bradley","year":"2011","journal-title":"G3 Genes Genomes Genet."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0080","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1073\/pnas.0712244105","article-title":"A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis","volume":"105","author":"Yoshimoto","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0085","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.devcel.2010.09.010","article-title":"The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells","volume":"19","author":"Matson","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jconrel.2023.09.027_bb0090","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature10239","article-title":"DMRT1 prevents female reprogramming in the postnatal mammalian testis","volume":"476","author":"Matson","year":"2011","journal-title":"Nature."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0095","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/ng.2890","article-title":"Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle","volume":"46","author":"Chen","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0100","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1101\/gr.162172.113","article-title":"Epigenetic modification and inheritance in sexual reversal of fish","volume":"24","author":"Shao","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0105","first-page":"1","article-title":"Genome editing reveals dmrt1 as an essential male sex-determining gene in Chinese tongue sole (Cynoglossus semilaevis)","volume":"7","author":"Cui","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0110","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1101\/gr.275962.121","article-title":"ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation","volume":"32","author":"Tang","year":"2022","journal-title":"Genome Res."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0115","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2010-11-8-r90","article-title":"Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites","volume":"11","author":"Betel","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0120","first-page":"1","article-title":"Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal","author":"Wang","year":"2022","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0125","series-title":"BioRxiv 463034 [Preprint]","article-title":"Protein complex prediction with AlphaFold-Multimer","author":"Evans","year":"2021"},{"key":"10.1016\/j.jconrel.2023.09.027_bb0130","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0135","doi-asserted-by":"crossref","first-page":"W276","DOI":"10.1093\/nar\/gkac240","article-title":"Search and sequence analysis tools services from EMBL-EBI in 2022","volume":"50","author":"Madeira","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"3.22","key":"10.1016\/j.jconrel.2023.09.027_bb0140","article-title":"Isolation and characterization of exosomes from cell culture supernatants","volume":"30","author":"Th\u00e9ry","year":"2006","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0145","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jconrel.2023.09.027_bb0150","first-page":"787","article-title":"SCAR-transformation of sex-specific SSR marker and its application in half-smooth tongue sole (Cynoglossus semiliaevis)","volume":"22","author":"Yang","year":"2014","journal-title":"J. Agric. Biotechnol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0155","doi-asserted-by":"crossref","first-page":"113961","DOI":"10.1016\/j.addr.2021.113961","article-title":"Dosing extracellular vesicles","volume":"178","author":"Gupta","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0160","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1080\/10717544.2018.1440667","article-title":"Follicle-stimulating hormone peptide-conjugated nanoparticles for targeted shRNA delivery lead to effective gro-\u03b1 silencing and antitumor activity against ovarian cancer","volume":"25","author":"Hong","year":"2018","journal-title":"Drug. Deliv."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0165","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1158\/0008-5472.CAN-08-4721","article-title":"Follicle-stimulating hormone peptide can facilitate paclitaxel nanoparticles to target ovarian carcinoma in vivo","volume":"69","author":"Zhang","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0170","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ygyno.2014.06.030","article-title":"Follicle-stimulating hormone polypeptide modified nanoparticle drug delivery system in the treatment of lymphatic metastasis during ovarian carcinoma therapy","volume":"135","author":"Fan","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0175","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0180","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/jcmm.12838","article-title":"MicroRNA-224 regulates self-renewal of mouse spermatogonial stem cells via targeting DMRT1","volume":"20","author":"Cui","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-016-2636-z","article-title":"Integrated analysis of miRNA and mRNA expression profiles in tilapia gonads at an early stage of sex differentiation","volume":"17","author":"Tao","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jconrel.2023.09.027_bb0190","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.theriogenology.2015.11.006","article-title":"Coordinated microRNA and messenger RNA expression profiles for understanding sexual dimorphism of gonads and the potential roles of microRNA in the steroidogenesis pathway in Nile tilapia (Oreochromis niloticus)","volume":"85","author":"Wang","year":"2016","journal-title":"Theriogenology."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-83891-w","article-title":"Identification of sex differentiation-related microRNA and long non-coding RNA in Takifugu rubripes gonads","volume":"11","author":"Yan","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ircmb.2018.02.001","article-title":"Follicle-stimulating hormone receptor: advances and remaining challenges","volume":"338","author":"De Pascali","year":"2018","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0205","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nature03206","article-title":"Structure of human follicle-stimulating hormone in complex with its receptor","volume":"433","author":"Fan","year":"2005","journal-title":"Nature."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0210","doi-asserted-by":"crossref","first-page":"12491","DOI":"10.1073\/pnas.1206643109","article-title":"Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor","volume":"109","author":"Jiang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0215","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2023.09.027_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3402\/jev.v4.26316","article-title":"Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting","volume":"4","author":"Wiklander","year":"2015","journal-title":"J. Extracell. Vesicles."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0225","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jconrel.2015.09.031","article-title":"Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of paclitaxel in autologous prostate cancer cells","volume":"220","author":"Saari","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.09.027_bb0230","first-page":"1","article-title":"Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a","volume":"17","author":"Ma","year":"2019","journal-title":"Cell Commun. Sig."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0235","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/acsnano.6b07607","article-title":"Re-engineering extracellular vesicles as smart nanoscale therapeutics","volume":"11","author":"Armstrong","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2023.09.027_bb0240","doi-asserted-by":"crossref","first-page":"121137","DOI":"10.1016\/j.biomaterials.2021.121137","article-title":"M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages","volume":"278","author":"Gunassekaran","year":"2021","journal-title":"Biomaterials."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12979-019-0150-2","article-title":"RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer\u2019s disease","volume":"16","author":"Cui","year":"2019","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.jconrel.2023.09.027_bb0250","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.7150\/thno.20524","article-title":"Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide","volume":"8","author":"Vandergriff","year":"2018","journal-title":"Theranostics."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0255","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.tips.2020.07.002","article-title":"Modulating the blood\u2013testis barrier towards increasing drug delivery","volume":"41","author":"Mao","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0260","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/mt.2012.180","article-title":"Systemically injected exosomes targeted to EGFR deliver antitumor microrna to breast cancer cells","volume":"21","author":"Ohno","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0265","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1038\/nprot.2012.131","article-title":"Exosome-mediated delivery of siRNA in vitro and in vivo","volume":"7","author":"El-Andaloussi","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0270","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41565-017-0012-z","article-title":"Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression","volume":"13","author":"Pi","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0275","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12111","article-title":"Exogenous loading of miRNAs into small extracellular vesicles","volume":"10","author":"de Abreu","year":"2021","journal-title":"J. Extracell. Vesicles."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0280","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1210\/er.2002-0025","article-title":"The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and Sox9 [Sry-related high-mobility group (HMG) box 9]","volume":"24","author":"Harley","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0285","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2010-11-4-205","article-title":"Are homologies in vertebrate sex determination due to shared ancestry or to limited options?","volume":"11","author":"Marshall Graves","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0290","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/82652","article-title":"A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse","volume":"26","author":"Bishop","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0295","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/90046","article-title":"Sox9 induces testis development in XX transgenic mice","volume":"28","author":"Vidal","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.114.122796","article-title":"High-throughput sequencing analyses of XX genital ridges lacking FOXL2 reveal DMRT1 up-regulation before SOX9 expression during the sex-reversal process in goats","volume":"91","author":"Elzaiat","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0305","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ydbio.2007.04.046","article-title":"Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation","volume":"307","author":"Kim","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0310","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000096238","article-title":"mRNA expression analysis and the molecular basis of neonatal testis defects in Dmrt1 mutant mice","volume":"1","author":"Fahrioglu","year":"2006","journal-title":"Sex. Dev."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0315","doi-asserted-by":"crossref","first-page":"966","DOI":"10.7150\/ijbs.6996","article-title":"Interleukin-8 regulates endothelial permeability by down-regulation of tight junction but not dependent on integrins induced focal adhesions","volume":"9","author":"Yu","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0320","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/er.2014-1101","article-title":"The mammalian blood-testis barrier: its biology and regulation","volume":"36","author":"Mruk","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1006293","article-title":"DMRT1 is required for mouse Spermatogonial stem cell maintenance and replenishment","volume":"12","author":"Zhang","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0330","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/mrd.22527","article-title":"Expression profile of doublesex\/male abnormal-3-related transcription factor-1 during gonadal sex change in the protogynous wrasse, Halichoeres trimaculatus","volume":"82","author":"Nozu","year":"2015","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0335","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/nsr\/nwy163","article-title":"DAZL is a master translational regulator of murine spermatogenesis","volume":"6","author":"Li","year":"2019","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0340","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nrm3089","article-title":"PIWI-interacting small RNAs: the vanguard of genome defence","volume":"12","author":"Siomi","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0345","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/10409238.2019.1603199","article-title":"Structure and function of eTudor domain containing TDRD proteins","volume":"54","author":"Gan","year":"2019","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0350","doi-asserted-by":"crossref","first-page":"100593","DOI":"10.1016\/j.cbd.2019.05.003","article-title":"Evolutionary significance and regulated expression of Tdrd family genes in gynogenetic Japanese flounder (Paralichthys olivaceus)","volume":"31","author":"Wang","year":"2019","journal-title":"Comp. Biochem. Physiol. - Part D Genomics Proteomics."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0355","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nsmb.3208","article-title":"Regulating the construction and demolition of the synaptonemal complex","volume":"23","author":"Cahoon","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jconrel.2023.09.027_bb0360","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1101\/gad.834100","article-title":"Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation","volume":"14","author":"Raymond","year":"2000","journal-title":"Genes Dev."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365923006144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365923006144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:49:20Z","timestamp":1759164560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365923006144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":72,"alternative-id":["S0168365923006144"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2023.09.027","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosome delivery to the testes for dmrt1 suppression: A powerful tool for sex-determining gene studies","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2023.09.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}