{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T15:01:28Z","timestamp":1767193288025,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Management"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jenvman.2023.119314","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T14:34:21Z","timestamp":1697553261000},"page":"119314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Nanofiltration combined with ozone-based processes for the removal of antineoplastic drugs from wastewater effluents"],"prefix":"10.1016","volume":"348","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-1812","authenticated-orcid":false,"given":"Teresa I.A.","family":"Gouveia","sequence":"first","affiliation":[]},{"given":"Ana M.","family":"Gorito","sequence":"additional","affiliation":[]},{"given":"Maria B.","family":"Crist\u00f3v\u00e3o","sequence":"additional","affiliation":[]},{"given":"Vanessa J.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3oG.","family":"Crespo","sequence":"additional","affiliation":[]},{"given":"Arminda","family":"Alves","sequence":"additional","affiliation":[]},{"given":"M. Fernando R.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Ana R.L.","family":"Ribeiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-6353","authenticated-orcid":false,"given":"Adri\u00e1n M.T.","family":"Silva","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-0147","authenticated-orcid":false,"given":"M\u00f3nica S.F.","family":"Santos","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"year":"1998","series-title":"Standard Methods for the Examination of Water and Wastewater","key":"10.1016\/j.jenvman.2023.119314_bib1"},{"year":"2021","series-title":"Chapter 7: Health Effects Evaluation: Screening Analysis","key":"10.1016\/j.jenvman.2023.119314_bib2"},{"key":"10.1016\/j.jenvman.2023.119314_bib3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.seppur.2018.11.059","article-title":"Removal of pharmaceuticals in water by introduction of ozonated microbubbles","volume":"212","author":"Azuma","year":"2019","journal-title":"Separ. Purif. Technol."},{"issue":"4","key":"10.1016\/j.jenvman.2023.119314_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/01919518208550955","article-title":"Determination of Ozone in water by the indigo method - a submitted standard method","volume":"4","author":"Bader","year":"1982","journal-title":"Ozone Sci. Eng."},{"key":"10.1016\/j.jenvman.2023.119314_bib5","article-title":"Evaluation of a full-scale wastewater treatment plant upgraded with ozonation and biological post-treatments: abatement of micropollutants, formation of transformation products and oxidation by-products","volume":"129","author":"Bourgin","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.jenvman.2023.119314_bib6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.watres.2017.05.018","article-title":"Effect of operational and water quality parameters on conventional ozonation and the advanced oxidation process O3\/H2O2: kinetics of micropollutant abatement, transformation product and bromate formation in a surface water","volume":"122","author":"Bourgin","year":"2017","journal-title":"Water Res."},{"issue":"4","key":"10.1016\/j.jenvman.2023.119314_bib7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/09593332508618403","article-title":"Ozonation of 1-naphthalene, 1,5-naphthalene, and 3-nitrobenzene sulphonic acids in aqueous solutions","volume":"23","author":"Calderara","year":"2002","journal-title":"Environ. Technol."},{"year":"2002","series-title":"Prednisone","key":"10.1016\/j.jenvman.2023.119314_bib8"},{"key":"10.1016\/j.jenvman.2023.119314_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128775","article-title":"Degradation and mineralization of ofloxacin by ozonation and peroxone (O3\/H2O2) process","volume":"269","author":"Chen","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jenvman.2023.119314_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2022.120565","article-title":"Treatment of anticancer drugs in a real wastewater effluent using nanofiltration: a pilot scale study","author":"Crist\u00f3v\u00e3o","year":"2022","journal-title":"Separ. Purif. Technol."},{"year":"2010","series-title":"Impurities: Guideline for Residual Solvents","key":"10.1016\/j.jenvman.2023.119314_bib11"},{"year":"2018","series-title":"Guideline on Setting Health Based Exposure Limits for Use in Risk Identification in the Manufacture of Different Medicinal Products in Shared Facilities","key":"10.1016\/j.jenvman.2023.119314_bib12"},{"year":"2006","series-title":"Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use","key":"10.1016\/j.jenvman.2023.119314_bib13"},{"year":"2011","series-title":"Exposure Factors Handbook","key":"10.1016\/j.jenvman.2023.119314_bib14"},{"year":"2012","series-title":"Projeto De Regulamento Que Estabelece as Condi\u00e7\u00f5es Do Esquema De Aprova\u00e7\u00e3o Em Portugal Para Os Produtos Em Contacto Com A \u00c1gua Destinada Ao Consumo Humano","key":"10.1016\/j.jenvman.2023.119314_bib15"},{"issue":"3","key":"10.1016\/j.jenvman.2023.119314_bib16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1747-6593.2009.00169.x","article-title":"Cyclophosphamide degradation by advanced oxidation processes","volume":"24","author":"Fern\u00e1ndez","year":"2010","journal-title":"Water Environ. J."},{"key":"10.1016\/j.jenvman.2023.119314_bib17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.scitotenv.2016.02.202","article-title":"Ozonation of hospital raw wastewaters for cytostatic compounds removal. Kinetic modelling and economic assessment of the process","volume":"556","author":"Ferre-Aracil","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.jenvman.2023.119314_bib18","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.2166\/ws.2019.087","article-title":"Occurrence of emerging contaminants in environmental surface waters and their analytical methodology \u2013 a review","volume":"19","author":"Galindo-Miranda","year":"2019","journal-title":"Water Supply"},{"key":"10.1016\/j.jenvman.2023.119314_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148855","article-title":"Ozonation of cytostatic drugs in aqueous phase","volume":"795","author":"Garcia-Costa","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2023.119314_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129743","article-title":"Intensification strategies for cytostatics degradation by ozone-based processes in aqueous phase","volume":"440","author":"Garcia-Costa","year":"2022","journal-title":"J. Hazard Mater."},{"issue":"16","key":"10.1016\/j.jenvman.2023.119314_bib21","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1007\/s00216-014-7805-9","article-title":"Occurrence of cytostatic compounds in hospital effluents and wastewaters, determined by liquid chromatography coupled to high-resolution mass spectrometry","volume":"406","author":"G\u00f3mez-Canela","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"issue":"4","key":"10.1016\/j.jenvman.2023.119314_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2021.105315","article-title":"Ozone-based water treatment (O3, O3\/UV, O3\/H2O2) for removal of organic micropollutants, bacteria inactivation and regrowth prevention","volume":"9","author":"Gorito","year":"2021","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jenvman.2023.119314_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105236","article-title":"New insights on cytostatic drug risk assessment in aquatic environments based on measured concentrations in surface waters","volume":"133","author":"Gouveia","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.jenvman.2023.119314_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121944","article-title":"Antineoplastic drugs in urban wastewater: occurrence, nanofiltration treatment and toxicity screening","author":"Gouveia","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jenvman.2023.119314_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158559","article-title":"Are cytostatic drugs in surface waters a potential threat?","volume":"853","author":"Gouveia","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2023.119314_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.130883","article-title":"Multi-target analysis of cytostatics in hospital effluents over a 9-month period","volume":"448","author":"Gouveia","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2023.119314_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.scitotenv.2020.139995","article-title":"Liquid-liquid extraction as a simple tool to quickly quantify fourteen cytostatics in urban wastewaters and access their impact in aquatic biota","volume":"740","author":"Gouveia","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"15","key":"10.1016\/j.jenvman.2023.119314_bib28","doi-asserted-by":"crossref","first-page":"14687","DOI":"10.1007\/s11356-016-7069-3","article-title":"Fate and effects of the residues of anticancer drugs in the environment","volume":"23","author":"Heath","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"year":"2022","series-title":"List of Classifications","key":"10.1016\/j.jenvman.2023.119314_bib29"},{"year":"2015","series-title":"Williams Hematology, 9e","author":"Izar","key":"10.1016\/j.jenvman.2023.119314_bib30"},{"year":"2022","series-title":"Mycophenolic Acid","author":"Katiboina","key":"10.1016\/j.jenvman.2023.119314_bib31"},{"issue":"3","key":"10.1016\/j.jenvman.2023.119314_bib32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijpam.2022.02.002","article-title":"Fetal malformations associated with exposure to mycophenolic acid during the first trimester","volume":"9","author":"Khan","year":"2022","journal-title":"Int. J. Pediatr. Adolescent Med."},{"key":"10.1016\/j.jenvman.2023.119314_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106543","article-title":"Anticancer drugs in the aquatic ecosystem: environmental occurrence, ecotoxicological effect and risk assessment","volume":"153","author":"Li","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.jenvman.2023.119314_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jwpe.2021.102038","article-title":"Mechanism of pre-ozonation in control of protein fouling of ultrafiltration membranes: synergistic effect between ozone oxidation and aeration","volume":"41","author":"Miao","year":"2021","journal-title":"J. Water Process Eng."},{"key":"10.1016\/j.jenvman.2023.119314_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2018.03.042","article-title":"Evaluation of advanced oxidation processes for water and wastewater treatment \u2013 a critical review","volume":"139","author":"Miklos","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.jenvman.2023.119314_bib36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.seppur.2013.12.006","article-title":"Pharmaceuticals removal from natural water by nanofiltration combined with advanced tertiary treatments (solar photo-Fenton, photo-Fenton-like Fe(III)\u2013EDDS complex and ozonation)","volume":"122","author":"Miralles-Cuevas","year":"2014","journal-title":"Separ. Purif. Technol."},{"key":"10.1016\/j.jenvman.2023.119314_bib37","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cattod.2017.10.032","article-title":"Antibiotics abatement in synthetic and real aqueous matrices by H2O2\/natural magnetite","volume":"313","author":"Munoz","year":"2018","journal-title":"Catal. Today"},{"year":"2021","series-title":"Pubchem - Capecitabine","author":"National Library of Medicine","key":"10.1016\/j.jenvman.2023.119314_bib38"},{"key":"10.1016\/j.jenvman.2023.119314_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.135263","article-title":"Water treatment intensification using a monophasic hybrid process coupling nanofiltration and ozone\/hydrogen peroxide advanced oxidation","volume":"437","author":"Ouali","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.jenvman.2023.119314_bib40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-8809(01)00258-4","article-title":"Ecological relative risk (EcoRR): another approach for risk assessment of pesticides in agriculture","volume":"91","author":"S\u00e1nchez-Bayo","year":"2002","journal-title":"Agric. Ecosyst. Environ."},{"key":"10.1016\/j.jenvman.2023.119314_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115474","article-title":"Disinfection by-products in drinking water: occurrence, toxicity and abatement","volume":"267","author":"Srivastav","year":"2020","journal-title":"Environ. Pollut."},{"issue":"10","key":"10.1016\/j.jenvman.2023.119314_bib42","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1002\/etc.4524","article-title":"Environmental risk assessment for the active pharmaceutical ingredient mycophenolic acid in European surface waters","volume":"38","author":"Straub","year":"2019","journal-title":"Environ. Toxicol. Chem."},{"issue":"11","key":"10.1016\/j.jenvman.2023.119314_bib43","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/S0043-1354(98)00099-2","article-title":"Occurrence of drugs in German sewage treatment plants and rivers1Dedicated to Professor Dr. Klaus Haberer on the occasion of his 70th birthday.1","volume":"32","author":"Ternes","year":"1998","journal-title":"Water Res."},{"issue":"7","key":"10.1016\/j.jenvman.2023.119314_bib44","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0043-1354(02)00457-8","article-title":"Ozonation of drinking water: Part I. Oxidation kinetics and product formation","volume":"37","author":"von Gunten","year":"2003","journal-title":"Water Res."},{"key":"10.1016\/j.jenvman.2023.119314_bib45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jhazmat.2019.121898","article-title":"Elimination of isothiazolinone biocides in reverse osmosis concentrate by ozonation: a two-phase kinetics and a non-linear surrogate model","volume":"389","author":"Wang","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2023.119314_bib46","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.envpol.2017.08.032","article-title":"Occurrence, fate and transformation of emerging contaminants in water: an overarching review of the field","volume":"231","author":"Wilkinson","year":"2017","journal-title":"Environ. Pollut."}],"container-title":["Journal of Environmental Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301479723021023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301479723021023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T10:58:26Z","timestamp":1759575506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301479723021023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":46,"alternative-id":["S0301479723021023"],"URL":"https:\/\/doi.org\/10.1016\/j.jenvman.2023.119314","relation":{},"ISSN":["0301-4797"],"issn-type":[{"type":"print","value":"0301-4797"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanofiltration combined with ozone-based processes for the removal of antineoplastic drugs from wastewater effluents","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Management","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jenvman.2023.119314","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"119314"}}