{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:36:27Z","timestamp":1778006187114,"version":"3.51.4"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007525","name":"Universit\u00e9 de Rennes 1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007525","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Fundacao para a Ciencia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/Multi\/04349\/2019"],"award-info":[{"award-number":["UID\/Multi\/04349\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Inorganic Biochemistry"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jinorgbio.2024.112788","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T07:53:37Z","timestamp":1732866817000},"page":"112788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Metal (Au, Pt, Pd, Ni) Bis(dithiolene) complexes as dual-action agents combating cancer and trypanosomatid infections"],"prefix":"10.1016","volume":"264","author":[{"given":"Hadi","family":"Hachem","sequence":"first","affiliation":[]},{"given":"Yann","family":"Le Gal","sequence":"additional","affiliation":[]},{"given":"Olivier","family":"Jeannin","sequence":"additional","affiliation":[]},{"given":"Dominique","family":"Lorcy","sequence":"additional","affiliation":[]},{"given":"Gonzalo","family":"Scalese","sequence":"additional","affiliation":[]},{"given":"Leticia","family":"P\u00e9rez-D\u00edaz","sequence":"additional","affiliation":[]},{"given":"Dinorah","family":"Gambino","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio P.","family":"Matos","sequence":"additional","affiliation":[]},{"given":"Fernanda","family":"Marques","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.jinorgbio.2024.112788_bb0005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.4155\/fmc-2018-9999","article-title":"Special focus: metals in medicine","volume":"10","author":"Spencer","year":"2018","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0010","doi-asserted-by":"crossref","first-page":"7289","DOI":"10.3390\/ijms24087289","article-title":"Metal-based complexes in cancer","volume":"24","author":"Riccardi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0015","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0020","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.7150\/thno.69424","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejmech.2017.04.007","article-title":"Platinum, palladium, gold and ruthenium complexes as anticancer agents: current clinical uses, cytotoxicity studies and future perspectives","volume":"142","author":"Lazarevi\u0107","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0030","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.3390\/molecules27196485","article-title":"Metallo-drugs in cancer therapy: past, present and future","volume":"27","author":"Lucaciu","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0035","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12885-017-3234-4","article-title":"Infections and cancer: the \u201cfifty shades of immunity\u201d hypothesis","volume":"17","author":"Jacqueline","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0040","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.2147\/DDDT.S275007","article-title":"Ruthenium complexes as anticancer agents: a brief history and perspectives","volume":"14","author":"Lee","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0045","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.2174\/0929867323666160504103843","article-title":"Gold complexes for therapeutic purposes: an updated patent review (2010-2015)","volume":"23","author":"Nardon","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0050","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.3390\/molecules23061410","article-title":"Gold-based medicine: a paradigm shift in anti-cancer therapy?","volume":"23","author":"Yeo","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0055","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1039\/D1CS00933H","article-title":"Recent development of gold(I) and gold(III) complexes as therapeutic agents for cancer diseases","volume":"51","author":"Lu","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0060","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1039\/C4DT00022F","article-title":"Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure","volume":"43","author":"Gli\u0161i\u0107","year":"2014","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0065","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.3390\/molecules25215075","article-title":"Repurposing auranofin and evaluation of a new gold(I) compound for the search of treatment of human and cattle parasitic diseases: from protozoa to helminth infections","volume":"25","author":"Feng","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0070","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.drudis.2022.02.010","article-title":"Repurposing of the gold drug auranofin and a review of its derivatives as antibacterial therapeutics","volume":"27","author":"Liu","year":"2022","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40268-015-0083-y","article-title":"Auranofin: repurposing an old drug for a golden new age","volume":"15","author":"Roder","year":"2015","journal-title":"Drugs R D"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0080","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10534-017-0007-0","article-title":"Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents","volume":"30","author":"Massai","year":"2017","journal-title":"BioMetals"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0085","article-title":"Phase I clinical trial results of auranofin, a novel antiparasitic agent","volume":"61","author":"Capparelli","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2023.215429","article-title":"Antibiotics: a \u201cGOLDen\u201d promise?","volume":"500","author":"Yeo","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0095","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.exppara.2012.09.004","article-title":"Plasmodium falciparum: the potential of the cancer chemotherapeutic agent cisplatin and its analogues as anti-malarials","volume":"132","author":"Murray","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0100","first-page":"89","article-title":"Trypanocidal effects of cisplatin alone and in combination with nigella sativa oil on experimentally infected mice with Trypanosoma evansi","volume":"13","author":"Nassef","year":"2018","journal-title":"Iran. J. Parasitol."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0105","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4274\/tpd.galenos.2022.30974","article-title":"Parasite and cancer relationship","volume":"46","author":"\u00c7elik","year":"2022","journal-title":"Turkiye Parazitol. Derg."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006915","article-title":"Pearls collections: what we can learn about infectious disease and cancer","volume":"14","author":"Knoll","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0115","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180935","article-title":"Parasites as negative regulators of cancer","volume":"38","author":"Callejas","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0120","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1515\/pac-2018-0901","article-title":"Anticancer properties of gold complexes with biologically relevant ligands","volume":"91","author":"Fern\u00e1ndez-Moreira","year":"2019","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0125","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/138955706775475939","article-title":"The use of anticancer drugs in antiparasitic chemotherapy","volume":"6","author":"Klinkert","year":"2006","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0130","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1002\/anie.200502756","article-title":"Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases","volume":"45","author":"Urig","year":"2006","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0135","series-title":"Trypanosomatid Diseases: Molecular Routes to Drug Discovery","first-page":"167","article-title":"Trypanothione-based redox metabolism of trypanosomatids","author":"Comini","year":"2013"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0140","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/BJ20050911","article-title":"Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome","volume":"391","author":"Ariyanayagam","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.freeradbiomed.2018.10.436","article-title":"Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi","volume":"130","author":"Mes\u00edas","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0150","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/j.1742-4658.2012.08557.x","article-title":"Drug target validation of the trypanothione pathway enzymes through metabolic modelling","volume":"279","author":"Olin-Sandoval","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0155","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2958.2009.06761.x","article-title":"Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods","volume":"74","author":"Wyllie","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2019.110904","article-title":"On the path to gold: Monoanionic au bisdithiolate complexes with antimicrobial and antitumor activities","volume":"202","author":"Sousa","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0165","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1039\/d0mt00064g","article-title":"Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents","volume":"12","author":"Fontinha","year":"2020","journal-title":"Metallomics"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0170","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.3390\/ijms23137146","article-title":"Broad Spectrum functional activity of structurally related monoanionic au(III) Bis(Dithiolene) complexes","volume":"23","author":"Le Gal","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0175","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.3390\/pharmaceutics15031030","article-title":"Block copolymer micelles encapsulating au(III) bis(dithiolene) complexes as promising nanostructures with antiplasmodial activity","volume":"15","author":"Santos","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0180","doi-asserted-by":"crossref","first-page":"7636","DOI":"10.1021\/acs.jmedchem.7b00143","article-title":"Nitroimidazoles: molecular fireworks that combat a broad spectrum of infectious diseases","volume":"60","author":"Ang","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0185","doi-asserted-by":"crossref","first-page":"16961","DOI":"10.1021\/ja907426s","article-title":"A single-component molecular metal based on a thiazole dithiolate gold complex","volume":"131","author":"Tenn","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0190","doi-asserted-by":"crossref","first-page":"15683","DOI":"10.1039\/C5DT02534F","article-title":"Gold dithiolene complexes: easy access to 2-alkylthio-thiazole dithiolate complexes","volume":"44","author":"Filatre-Furcate","year":"2015","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0195","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1021\/ic501293z","article-title":"Radical or not radical: compared structures of metal (M = Ni, au) bis-dithiolene complexes with a thiazole backbone","volume":"53","author":"Filatre-Furcate","year":"2014","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0200","doi-asserted-by":"crossref","first-page":"6580","DOI":"10.1039\/C8DT00818C","article-title":"Neutral closed-shell nickel bis(2-alkylthiothiazole-4,5-dithiolate) complexes as single component molecular conductors","volume":"47","author":"Hachem","year":"2018","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0205","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jorganchem.2016.06.033","article-title":"Chemical transformation of dithiolene ligands in heteroleptic and homoleptic complexes (M = Ti, Zn, au)","volume":"819","author":"Filatre-Furcate","year":"2016","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0210","first-page":"435","article-title":"SIR92 a program for automatic solution of crystal structures by direct methods optimized for powder data","volume":"27","author":"Altomare","year":"1994","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0215","first-page":"3","article-title":"Crystal structure refinement with SHELXL","volume":"C71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0220","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1107\/S0021889812029111","article-title":"WinGX and ORTEP for windows: an update","volume":"45","author":"Farrugia","year":"2012","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0225","doi-asserted-by":"crossref","first-page":"11903","DOI":"10.1039\/D4DT01458H","article-title":"Structure-activity relationship of anticancer and antiplasmodial gold bis(dithiolene) complexes","volume":"53","author":"Vitr\u00e9","year":"2024","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2022.112016","article-title":"New multifunctional Ru(II) organometallic compounds show activity against Trypanosoma brucei and Leishmania infantum","volume":"237","author":"Rivas","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0235","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1039\/D2DT03869B","article-title":"Multifunctional organometallic compounds for the treatment of Chagas disease: re(I) tricarbonyl compounds with two different bioactive ligands","volume":"52","author":"Soba","year":"2023","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fchbi.2023.1304571","article-title":"Facing diseases caused by trypanosomatid parasites: rational design of multifunctional oxidovanadium (IV) complexes with bioactive ligands","volume":"2","author":"Scalese","year":"2024","journal-title":"Front. Chem. Biol."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0245","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1021\/acs.inorgchem.4c01125","article-title":"Multifunctional organometallic compounds active against infective trypanosomes: Ru (II) Ferrocenyl derivatives with two different bioactive ligands","volume":"63","author":"Rivas","year":"2024","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0250","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.3390\/molecules26175375","article-title":"Heteroleptic oxidovanadium(V) complexes with activity against infective and non-infective stages of trypanosoma cruzi","volume":"26","author":"Scalese","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0255","doi-asserted-by":"crossref","unstructured":"M. Vieites, P. Smircich, B. Paraj\u00f3n-Costa, J. Rodr\u00edguez, et. al. Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase. J. Biol. Inorg. Chem., 13 (2008) 723\u201335. doi: https:\/\/doi.org\/10.1007\/s00775-008-0358-7.","DOI":"10.1007\/s00775-008-0358-7"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0260","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/j.1939-4640.2003.tb03137.x","article-title":"Utility of the nitroblue tetrazolium reduction test for assessment of reactive oxygen species production by seminal leukocytes and spermatozoa","volume":"24","author":"Esfandiari","year":"2003","journal-title":"J. Androl."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0265","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.3390\/antibiotics11081010","article-title":"Tuning the biological activity of camphorimine complexes through metal selection","volume":"11","author":"Costa","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0270","doi-asserted-by":"crossref","unstructured":"P. Greenspan, E. P. Mayer, S. .D Fowler. Nile red: a selective fluorescent stain for intracellular lipid droplets. J. Cell Biol., 100 (1985) 965\u2013973. doi: https:\/\/doi.org\/10.1083\/jcb.100.3.965.","DOI":"10.1083\/jcb.100.3.965"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0275","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ccr.2018.09.012","article-title":"Zero-, one- and two-dimensional bis(dithiolato)metal complexes with unique physical and chemical properties","volume":"380","author":"Kusamoto","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0280","doi-asserted-by":"crossref","first-page":"9610","DOI":"10.1021\/ic051260q","article-title":"[M(R-dmet)2] bis(1,2-dithiolenes): a promising new class intermediate between [M(dmit)2] and [M(R,R\u2019-timdt)2] (M = Ni, Pd, Pt)","volume":"44","author":"Aragoni","year":"2005","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0285","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.inoche.2006.10.019","article-title":"First example of a near-IR photodetector based on neutral [M(R-dmet)2] bis(1,2-dithiolene) metal complexes","volume":"10","author":"Aragoni","year":"2007","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0290","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.21037\/gs-20-325","article-title":"Secondary and tertiary ovarian cancer recurrence: what is the best management?","volume":"9","author":"Garzon","year":"2020","journal-title":"Gland Surg."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0295","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/AOG.0000000000004173","article-title":"Updates and new options in advanced epithelial ovarian cancer treatment","volume":"137","author":"Kurnit","year":"2021","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0300","doi-asserted-by":"crossref","first-page":"7585","DOI":"10.3390\/ijms24087585","article-title":"Cisplatin in ovarian cancer treatment-known limitations in therapy force new solutions","volume":"24","author":"Zo\u0144","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0305","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.3390\/cancers15215136","article-title":"Auranofin induces lethality driven by reactive oxygen species in high-grade serous ovarian cancer cells","volume":"15","author":"Abdalbari","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0310","doi-asserted-by":"crossref","first-page":"96062","DOI":"10.18632\/oncotarget.21708","article-title":"Selection and characterization of a human ovarian cancer cell line resistant to auranofin","volume":"8","author":"Landini","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0315","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1177\/1087057104265386","article-title":"Comparison of the usefulness of the MTT, ATP, and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines","volume":"9","author":"Mueller","year":"2004","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0320","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1749-8546-6-39","article-title":"Thitimetharoch cytotoxic and apoptotic effects of six herbal plants against the human hepatocarcinoma (HepG2) cell line","volume":"31","author":"Machana","year":"2011","journal-title":"Chin. Med."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0325","article-title":"Metal compounds in the development of antiparasitic agents: rational design from basic chemistry to the clinic","author":"Gambino","year":"2019","journal-title":"Met. Ions Life Sci."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0330","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/138955706775475939","article-title":"The use of anticancer drugs in antiparasitic chemotherapy","volume":"6","author":"Klinkert","year":"2006","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0335","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.pt.2014.04.003","article-title":"Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects","volume":"30","author":"Patterson","year":"2014","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0340","first-page":"153","article-title":"Sustainable anti-trypanosomatid drugs: an aspirational goal for medicinal chemistry","volume":"52","author":"Bolognesi","year":"2019","journal-title":"Annu. Rep. Med. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0345","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.816266","article-title":"Otero, facing diseases caused by trypanosomatid parasites: rational design of Pd and Pt complexes with bioactive ligands","volume":"9","author":"Gambino","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0350","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2147\/JEP.S267378","article-title":"Review on experimental treatment strategies against trypanosoma cruzi","volume":"13","author":"Mazzeti","year":"2021","journal-title":"J. Exp. Pharmacol."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0355","doi-asserted-by":"crossref","first-page":"17756","DOI":"10.1039\/C9NJ02589H","article-title":"Exploring oxidovanadium(iv) homoleptic complexes with 8-hydroxyquinoline derivatives as prospective antitrypanosomal agents","volume":"43","author":"Scalese","year":"2019","journal-title":"New J. Chem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0360","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5381692","article-title":"Understanding of ROS-inducing strategy in anticancer therapy","volume":"2019","author":"Kim","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0365","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.freeradbiomed.2012.09.002","article-title":"Detection of reactive oxygen species derived from the family of NOX NADPH oxidases","volume":"53","author":"Maghzal","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0370","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/15321810500403722","article-title":"A quantitative nitroblue tetrazolium assay for determining intracellular superoxide anion production in phagocytic cells","volume":"27","author":"Choi","year":"2006","journal-title":"J. Immunoass. Immunochem."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0375","first-page":"2977","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"2016","author":"Redza-Dutordoir","year":"1863","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0380","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2121-14-32","article-title":"Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis","volume":"14","author":"Brentnall","year":"2013","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0385","first-page":"3077","article-title":"Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines","volume":"59","author":"Henkels","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0390","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/sj.bjc.6604223","article-title":"Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt","volume":"98","author":"Yang","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0395","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1021\/mp070002r","article-title":"Caspase activation by anticancer drugs: the caspase storm","volume":"4","author":"Tao","year":"2007","journal-title":"Mol Pharm."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0400","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-62703-383-1_7","article-title":"Analysis of cell death by electron microscopy","volume":"1004","author":"Burattini","year":"2013","journal-title":"Methods Mol Biol."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0405","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/cdd.2012.34","article-title":"Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation","volume":"19","author":"Boren","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jinorgbio.2024.112788_bb0410","first-page":"435","article-title":"Lipid droplets and the management of cellular stress","volume":"92","author":"Jarc","year":"2019","journal-title":"Yale J Biol Med."}],"container-title":["Journal of Inorganic Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013424003131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0162013424003131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T01:52:23Z","timestamp":1741830743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0162013424003131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":82,"alternative-id":["S0162013424003131"],"URL":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2024.112788","relation":{},"ISSN":["0162-0134"],"issn-type":[{"value":"0162-0134","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metal (Au, Pt, Pd, Ni) Bis(dithiolene) complexes as dual-action agents combating cancer and trypanosomatid infections","name":"articletitle","label":"Article Title"},{"value":"Journal of Inorganic Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinorgbio.2024.112788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112788"}}