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Res."},{"issue":"3","key":"10.1016\/j.jtemb.2021.126745_bib0455","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1258\/002367790780866128","article-title":"Age related changes in weight and the concentrations of zinc and copper in the brain of the adult rat","volume":"24","author":"Palm","year":"1990","journal-title":"Lab. Anim."},{"key":"10.1016\/j.jtemb.2021.126745_bib0460","series-title":"Techniques and Instrumentation in Analytical Chemistry","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0167-9244(08)70143-4","article-title":"Chapter 1 - sampling and sample storage","author":"Aitio","year":"1994"},{"issue":"2","key":"10.1016\/j.jtemb.2021.126745_bib0465","doi-asserted-by":"crossref","first-page":"51","DOI":"10.6028\/jres.091.010","article-title":"Technical considerations for sampling and sample preparation of biomedical samples for trace element analysis","volume":"91","author":"Parr","year":"1986","journal-title":"J. Res. Nat. Bur. 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