{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:23:53Z","timestamp":1783027433541,"version":"3.54.6"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006126","name":"Hospital for Sick Children","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006126","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011272","name":"European Commission Seventh Framework Programme for Research and Technological Development Health","doi-asserted-by":"publisher","award":["305608"],"award-info":[{"award-number":["305608"]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002997","name":"Kidney Foundation","doi-asserted-by":"publisher","award":["15OKG18"],"award-info":[{"award-number":["15OKG18"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mad.2025.112115","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T19:36:00Z","timestamp":1758569760000},"page":"112115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Increased mTOR signaling secondary to a human ILK missense variant inhibits nephrogenesis with decreased metabolism"],"prefix":"10.1016","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-6302","authenticated-orcid":false,"given":"Xiangyue","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Kablawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wout F.J.","family":"Feitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten Y.","family":"Renkema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nine V.A.M.","family":"Knoers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-6464","authenticated-orcid":false,"given":"Norman D.","family":"Rosenblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.mad.2025.112115_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007313","article-title":"GLI3 repressor controls nephron number via regulation of Wnt11 and ret in ureteric tip cells","volume":"4","author":"Cain","year":"2009","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.mad.2025.112115_bib2","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1681\/ASN.2018111170","article-title":"Von Hippel-Lindau acts as a metabolic switch controlling nephron progenitor differentiation","volume":"30","author":"Cargill","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.mad.2025.112115_bib3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1074\/jbc.M110.159046","article-title":"ERK1\/2 phosphorylate raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)","volume":"286","author":"Carriere","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.mad.2025.112115_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113555","article-title":"Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung: evidence for a role in determining morphogenic properties of FGF7","volume":"9","author":"Carter","year":"2014","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.mad.2025.112115_bib5","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/bioinformatics\/btq431","article-title":"A framework for oligonucleotide microarray preprocessing","volume":"26","author":"Carvalho","year":"2010","journal-title":"Bioinformatics"},{"issue":"10","key":"10.1016\/j.mad.2025.112115_bib6","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/stmcls\/sxae047","article-title":"Integrin-linked kinase control dental pulp stem cell senescence via the mTOR signaling pathway","volume":"42","author":"Chen","year":"2024","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.mad.2025.112115_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/dvg.20452","article-title":"A transgenic mouse that reveals cell shape and arrangement during ureteric bud branching","volume":"47","author":"Chi","year":"2009","journal-title":"Genesis"},{"issue":"8","key":"10.1016\/j.mad.2025.112115_bib8","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1681\/ASN.2006010033","article-title":"Essential role of integrin-linked kinase in podocyte biology: bridging the integrin and slit diaphragm signaling","volume":"17","author":"Dai","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mad.2025.112115_bib9","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3389\/fonc.2019.01373","article-title":"mTORC1 as a regulator of mitochondrial functions and a therapeutic target in cancer","volume":"9","author":"de la Cruz L\u00f3pez","year":"2019","journal-title":"Front Oncol."},{"issue":"19","key":"10.1016\/j.mad.2025.112115_bib10","doi-asserted-by":"crossref","first-page":"11211","DOI":"10.1073\/pnas.95.19.11211","article-title":"Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B\/AKT by the integrin-linked kinase","volume":"95","author":"Delcommenne","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.mad.2025.112115_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1681\/ASN.2016020154","article-title":"The substantial loss of nephrons in healthy human kidneys with aging","volume":"28","author":"Denic","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"9","key":"10.1016\/j.mad.2025.112115_bib12","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1128\/MCB.01259-08","article-title":"Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1","volume":"29","author":"Distefano","year":"2009","journal-title":"Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.mad.2025.112115_bib13","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1681\/ASN.2005090921","article-title":"Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis","volume":"17","author":"El-Aouni","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.mad.2025.112115_bib14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/10409239409083485","article-title":"S6 phosphorylation and the p70s6k\/p85s6k","volume":"29","author":"Ferrari","year":"1994","journal-title":"Crit. Rev. Biochem Mol. Biol."},{"issue":"49","key":"10.1016\/j.mad.2025.112115_bib15","doi-asserted-by":"crossref","first-page":"19384","DOI":"10.1073\/pnas.0810584105","article-title":"mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization","volume":"105","author":"Gan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.mad.2025.112115_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ydbio.2011.09.027","article-title":"PI3K\/mTOR signaling regulates prostatic branching morphogenesis","volume":"360","author":"Ghosh","year":"2011","journal-title":"Dev. Biol."},{"issue":"21","key":"10.1016\/j.mad.2025.112115_bib17","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1101\/gad.912401","article-title":"Hierarchical phosphorylation of the translation inhibitor 4E-BP1","volume":"15","author":"Gingras","year":"2001","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.mad.2025.112115_bib18","doi-asserted-by":"crossref","first-page":"F374","DOI":"10.1152\/ajprenal.00509.2017","article-title":"Expression of ILK in renal stroma is essential for multiple aspects of renal development","volume":"315","author":"Gong","year":"2018","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"2","key":"10.1016\/j.mad.2025.112115_bib19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00018-021-04104-1","article-title":"Integrin-linked kinase (ILK): the known vs. The unknown and perspectives","volume":"79","author":"G\u00f3rska","year":"2022","journal-title":"Cell Mol. Life Sci."},{"issue":"12","key":"10.1016\/j.mad.2025.112115_bib20","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1101\/gad.10.12.1467","article-title":"Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of winged helix transcription factor BF-2","volume":"10","author":"Hatini","year":"1996","journal-title":"Genes Dev."},{"issue":"20","key":"10.1016\/j.mad.2025.112115_bib21","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1016\/j.yexcr.2011.09.011","article-title":"A novel cardioprotective p38-MAPK\/mTOR pathway","volume":"317","author":"Hern\u00e1ndez","year":"2011","journal-title":"Exp. Cell Res"},{"issue":"9","key":"10.1016\/j.mad.2025.112115_bib22","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nbt.2647","article-title":"DNA targeting specificity of RNA-guided Cas9 nucleases","volume":"31","author":"Hsu","year":"2013","journal-title":"Nat. Biotechnol."},{"issue":"10","key":"10.1016\/j.mad.2025.112115_bib23","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.3390\/cancers14102430","article-title":"Integrin \u03b12 and \u03b21 Cross-Communication with mTOR\/AKT and the CDK-Cyclin axis in hepatocellular carcinoma cells","volume":"14","author":"Juratli","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.mad.2025.112115_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest"},{"issue":"2","key":"10.1016\/j.mad.2025.112115_bib25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.stem.2008.05.020","article-title":"Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development","volume":"3","author":"Kobayashi","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"22","key":"10.1016\/j.mad.2025.112115_bib26","doi-asserted-by":"crossref","first-page":"14120","DOI":"10.1074\/jbc.M114.633057","article-title":"Rictor undergoes glycogen synthase kinase 3 (GSK3)-dependent, FBXW7-mediated ubiquitination and proteasomal degradation","volume":"290","author":"Koo","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mad.2025.112115_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00439-015-1610-1","article-title":"Whole-exome sequencing identifies mutations of TBC1D1 encoding a Rab-GTPase-activating protein in patients with congenital anomalies of the kidneys and urinary tract (CAKUT)","volume":"135","author":"Kosfeld","year":"2016","journal-title":"Hum. Genet"},{"issue":"4","key":"10.1016\/j.mad.2025.112115_bib28","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1242\/dev.109.4.775","article-title":"Hox-2.3 upstream sequences mediate lacz expression in intermediate mesoderm derivatives of transgenic mice","volume":"109","author":"Kress","year":"1990","journal-title":"Development"},{"issue":"W1","key":"10.1016\/j.mad.2025.112115_bib29","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"7266","key":"10.1016\/j.mad.2025.112115_bib30","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nature08468","article-title":"Integrin-linked kinase is an adaptor with essential functions during mouse development","volume":"461","author":"Lange","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mad.2025.112115_bib31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrm1789","article-title":"ILK, PINCH and parvin: the tIPP of integrin signalling","volume":"7","author":"Legate","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.mad.2025.112115_bib32","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1128\/MCB.25.9.3648-3657.2005","article-title":"Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis","volume":"25","author":"Leung-Hagesteijn","year":"2005","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.mad.2025.112115_bib33","first-page":"289","article-title":"ILK participates in renal interstitial fibrosis by altering the phenotype of renal tubular epithelial cells via TGF-\u03b21\/smad pathway","volume":"23","author":"Li","year":"2019","journal-title":"Eur. Rev. Med Pharm. Sci."},{"issue":"11","key":"10.1016\/j.mad.2025.112115_bib34","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1681\/ASN.2016111246","article-title":"Regulation of nephron progenitor cell Self-Renewal by intermediary metabolism","volume":"28","author":"Liu","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.mad.2025.112115_bib35","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1158\/0008-5472.CAN-07-5869","article-title":"Rictor and integrin-linked kinase interact and regulate akt phosphorylation and cancer cell survival","volume":"68","author":"McDonald","year":"2008","journal-title":"Cancer Res"},{"issue":"13","key":"10.1016\/j.mad.2025.112115_bib36","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.3390\/cancers14133209","article-title":"New perspectives on the role of integrin-linked kinase (ILK) signaling in cancer metastasis","volume":"14","author":"McDonald","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.mad.2025.112115_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69267-6","article-title":"\u03b21 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells","volume":"10","author":"Mousavizadeh","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.mad.2025.112115_bib38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ydbio.2008.09.010","article-title":"Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney","volume":"324","author":"Mugford","year":"2008","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.mad.2025.112115_bib39","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/ki.2015.319","article-title":"Prioritization and burden analysis of rare variants in 208 candidate genes suggest they do not play a major role in CAKUT","volume":"89","author":"Nicolaou","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.mad.2025.112115_bib40","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.semcdb.2018.08.013","article-title":"Impact of next generation sequencing on our understanding of CAKUT","volume":"91","author":"Nigam","year":"2019","journal-title":"Semin Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.mad.2025.112115_bib41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrneph.2014.95","article-title":"Next-generation sequencing for research and diagnostics in kidney disease","volume":"10","author":"Renkema","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"issue":"7","key":"10.1016\/j.mad.2025.112115_bib42","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"10.1016\/j.mad.2025.112115_bib43","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.biochi.2012.04.018","article-title":"Histone H3 phosphorylation - a versatile chromatin modification for different occasions","volume":"94","author":"Sawicka","year":"2012","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.mad.2025.112115_bib44","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cell.2017.03.035","article-title":"mTOR signaling in growth, metabolism, and disease [published correction appears in","volume":"169","author":"Saxton","year":"2017","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.mad.2025.112115_bib45","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1242\/dev.052845","article-title":"Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development","volume":"137","author":"Smeeton","year":"2010","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.mad.2025.112115_bib46","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1681\/ASN.2015020139","article-title":"Integrin-linked kinase controls renal branching morphogenesis via dual specificity phosphatase 8","volume":"27","author":"Smeeton","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.mad.2025.112115_bib47","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/ncb995","article-title":"Rheb is an essential regulator of S6K in controlling cell growth in drosophila","volume":"5","author":"Stocker","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.mad.2025.112115_bib48","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1214\/aos\/1074290335","article-title":"The positive false discovery rate: a Bayesian interpretation and the q -value","volume":"31","author":"Storey","year":"2003","journal-title":"Ann. Stat."},{"issue":"2","key":"10.1016\/j.mad.2025.112115_bib49","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1523-1755.2005.67108.x","article-title":"Functional consequences of integrin-linked kinase activation in podocyte damage","volume":"67","author":"Teixeira","year":"2005","journal-title":"Kidney Int"},{"issue":"8","key":"10.1016\/j.mad.2025.112115_bib50","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1007\/s00467-020-04752-8","article-title":"Metabolic programming of nephron progenitor cell fate","volume":"36","author":"Tortelote","year":"2021","journal-title":"Pedia Nephrol."},{"issue":"3","key":"10.1016\/j.mad.2025.112115_bib51","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1128\/MCB.19.3.2425","article-title":"The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells","volume":"19","author":"Tu","year":"1999","journal-title":"Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.mad.2025.112115_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031327","article-title":"Genes in the ureteric budding pathway: association study on vesico-ureteral reflux patients","volume":"7","author":"van Eerde","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.mad.2025.112115_bib53","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/bdra.23512","article-title":"AGORA, a data- and biobank for birth defects and childhood cancer","volume":"106","author":"van Rooij","year":"2016","journal-title":"Birth Defects Res A Clin. Mol. Teratol."},{"issue":"1","key":"10.1016\/j.mad.2025.112115_bib54","article-title":"Signaling crosstalk between the mTOR complexes","volume":"2","author":"Xie","year":"2014","journal-title":"Transl. (Austin)"},{"issue":"6","key":"10.1016\/j.mad.2025.112115_bib55","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1083\/jcb.153.6.1251","article-title":"A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction","volume":"153","author":"Yamaji","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mad.2025.112115_bib56","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/978-1-4939-9027-6_18","article-title":"Using seahorse machine to measure OCR and ECAR in cancer cells","volume":"1928","author":"Zhang","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"Pt 24","key":"10.1016\/j.mad.2025.112115_bib57","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1242\/jcs.00166","article-title":"Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites","volume":"115","author":"Zhang","year":"2002","journal-title":"J. Cell Sci."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425000910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425000910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:06:04Z","timestamp":1783026364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637425000910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":57,"alternative-id":["S0047637425000910"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2025.112115","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased mTOR signaling secondary to a human ILK missense variant inhibits nephrogenesis with decreased metabolism","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2025.112115","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112115"}}