{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T21:02:39Z","timestamp":1770238959827,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Oral Oncology Reports"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.oor.2023.100018","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T02:35:04Z","timestamp":1678415704000},"page":"100018","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Identification of a potential prognostic panel of biomarkers for stratification of head and neck squamous cell carcinoma based on HPV status and TP53 mutational status"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0014-2282","authenticated-orcid":false,"given":"Oriana","family":"Barros","sequence":"first","affiliation":[]},{"given":"Rita","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Vito G.","family":"D'Agostino","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Amado","sequence":"additional","affiliation":[]},{"given":"Lucio","family":"Santos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3636-5805","authenticated-orcid":false,"given":"Rui","family":"Vitorino","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.oor.2023.100018_bib1","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat Rev Dis Prim"},{"issue":"10","key":"10.1016\/j.oor.2023.100018_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics10100818","article-title":"Diagnostic and prognostic value of salivary biochemical markers in oral squamous cell carcinoma","volume":"10","author":"Bel\u2019skaya","year":"2020","journal-title":"Diagnostics"},{"issue":"1","key":"10.1016\/j.oor.2023.100018_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-66983-x","article-title":"Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer","volume":"10","author":"Dhawan","year":"2020","journal-title":"Sci Rep"},{"issue":"Cells","key":"10.1016\/j.oor.2023.100018_bib4","first-page":"1","article-title":"Prognostic cancer gene expression signatures: current status and challenges","volume":"10","author":"Qian","year":"2021","journal-title":"MD"},{"issue":"12","key":"10.1016\/j.oor.2023.100018_bib5","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1093\/annonc\/mdw307","article-title":"Statistical controversies in clinical research: prognostic gene signatures are not (yet) useful in clinical practice","volume":"27","author":"Michiels","year":"2016","journal-title":"Ann Oncol"},{"issue":"11","key":"10.1016\/j.oor.2023.100018_bib6","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x2020e11069","article-title":"Identification and clinical validation of gene signatures with grade and survival in head and neck carcinomas","volume":"54","author":"Ma","year":"2021","journal-title":"Braz J Med Biol Res"},{"issue":"1","key":"10.1016\/j.oor.2023.100018_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-16918-w","article-title":"Meta analysis: HPV and p16 pattern determines survival in patients with HNSCC and identifies potential new biologic subtype","volume":"7","author":"Albers","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.oor.2023.100018_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-16918-w","article-title":"Meta analysis: HPV and p16 pattern determines survival in patients with HNSCC and identifies potential new biologic subtype","volume":"7","author":"Albers","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.oor.2023.100018_bib9","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/ijc.30516","article-title":"Diagnostic accuracy of p16INK4a immunohistochemistry in oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis","volume":"140","author":"Prigge","year":"2017","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.oor.2023.100018_bib10","first-page":"139","article-title":"TP53 mutations in head and neck squamous cell carcinoma and their impact on disease progression and treatment response","volume":"176","author":"Zhou","year":"2019","journal-title":"Physiol Behav"},{"key":"10.1016\/j.oor.2023.100018_bib11","series-title":"A\u00a0TP53 mutation model for the prediction of prognosis and therapeutic responses in head and neck squamous cell carcinoma","first-page":"1","author":"Shi","year":"2021"},{"issue":"W1","key":"10.1016\/j.oor.2023.100018_bib12","doi-asserted-by":"crossref","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10.1016\/j.oor.2023.100018_bib13","first-page":"649","article-title":"UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"Neoplasia (United States) [Internet]"},{"issue":"5","key":"10.1016\/j.oor.2023.100018_bib14","article-title":"ToPP: tumor online prognostic analysis platform for prognostic feature selection and clinical patient subgroup selection","volume":"25","author":"Ouyang","year":"2022","journal-title":"iScience [Internet]"},{"issue":"8","key":"10.1016\/j.oor.2023.100018_bib15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.oor.2023.100018_bib16","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/nar\/gkg034","article-title":"STRING: a database of predicted functional associations between proteins","volume":"31","author":"von Mering","year":"2003","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"10.1016\/j.oor.2023.100018_bib17","doi-asserted-by":"crossref","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.oor.2023.100018_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/mc.23385","article-title":"TP53 mutations in head and neck cancer","volume":"61","author":"Nathan","year":"2022","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.oor.2023.100018_bib19","first-page":"58","article-title":"TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection","author":"Klinakis","year":"2020","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.oor.2023.100018_bib20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00439-014-1470-0","article-title":"Predicting survival in head and neck squamous cell carcinoma from TP53 mutation","volume":"134","author":"Masica","year":"2015","journal-title":"Hum Genet"},{"key":"10.1016\/j.oor.2023.100018_bib21","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1002\/jcb.25592","article-title":"TP53 mutations in head and neck squamous cell carcinoma and their impact on disease progression and treatment response","author":"Zhou","year":"2016","journal-title":"J\u00a0Cell Biochem"},{"issue":"18","key":"10.1016\/j.oor.2023.100018_bib22","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/onc.2010.614","article-title":"P16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors","volume":"30","author":"Romagosa","year":"2011","journal-title":"Oncogene"},{"issue":"APR","key":"10.1016\/j.oor.2023.100018_bib23","article-title":"CDKN2A copy number loss is an independent prognostic factor in HPV-negative head and neck squamous cell carcinoma","volume":"8","author":"Chen","year":"2018","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.oor.2023.100018_bib24","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1159\/000494473","article-title":"The association and clinical significance of CDKN2A promoter methylation in head and neck squamous cell carcinoma: a meta-analysis","volume":"50","author":"Zhou","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"3","key":"10.1016\/j.oor.2023.100018_bib25","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/jjco\/hyt223","article-title":"Prognostic impact of p16 and p53 expression in oropharyngeal squamous cell carcinomas","volume":"44","author":"Shinohara","year":"2014","journal-title":"Jpn J Clin Oncol"},{"issue":"1","key":"10.1016\/j.oor.2023.100018_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-016-2217-1","article-title":"A\u00a0pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients","volume":"16","author":"Chai","year":"2016","journal-title":"BMC Cancer"},{"issue":"9","key":"10.1016\/j.oor.2023.100018_bib28","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.3109\/00016489.2012.678944","article-title":"Transforming growth factor beta 1 genotype and p16 as prognostic factors in head and neck squamous cell carcinoma","volume":"132","author":"Lundberg","year":"2012","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.oor.2023.100018_bib29","series-title":"Transforming growth factor beta 1 genotype and p16 as prognostic factors in head and neck squamous cell carcinoma","first-page":"1006","author":"Lundberg","year":"2012"},{"key":"10.1016\/j.oor.2023.100018_bib30","series-title":"ASSOCIATION BETWEEN TRANSFORMING GROWTH FACTOR b1 GENETIC POLYMORPHISM AND RESPONSE TO CHEMORADIOTHERAPY IN HEAD AND NECK SQUAMOUS CELL CANCER","author":"Lundberg","year":"2009"},{"issue":"9","key":"10.1016\/j.oor.2023.100018_bib31","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1158\/1078-0432.CCR-17-1904","article-title":"TGFb1 genetic variants predict clinical outcomes of hpv-positive oropharyngeal cancer patients after definitive radiotherapy","volume":"24","author":"Tao","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.oor.2023.100018_bib33","series-title":"Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis","author":"Chen","year":"2014"},{"issue":"7","key":"10.1016\/j.oor.2023.100018_bib34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/jop.12731","article-title":"Prognostic significance of elevated serum CD44 levels in patients with oral squamous cell carcinoma","volume":"47","author":"Sawant","year":"2018","journal-title":"J\u00a0Oral Pathol Med"},{"key":"10.1016\/j.oor.2023.100018_bib35","first-page":"106","article-title":"CD44 and associated markers in oral rinses and tissues from oral and oropharyngeal cancer patients","author":"Cohen","year":"2020","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.oor.2023.100018_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-021-09033-7","article-title":"Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis","volume":"14","author":"Chen","year":"2014","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.oor.2023.100018_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156582","article-title":"Molecular portrait of oral tongue squamous cell carcinoma shown by integrative meta-analysis of expression profiles with validations","volume":"11","author":"Thangaraj","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.oor.2023.100018_bib38","series-title":"Expressions of matrix metalloproteinase-9 (MMP-9), dentin sialophosphoprotein (DSPP), and osteopontin (OPN) at histologically negative surgical margins may predict recurrence of oral squamous cell carcinoma [Internet]","author":"Ogbureke","year":"2012"},{"issue":"3","key":"10.1016\/j.oor.2023.100018_bib39","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/ijc.21092","article-title":"Serum matrix metalloproteinase-9 in head and neck squamous cell carcinoma is a prognostic marker","volume":"116","author":"Ruokolainen","year":"2005","journal-title":"Int J Cancer"},{"issue":"3 March","key":"10.1016\/j.oor.2023.100018_bib40","first-page":"16","article-title":"Diagnostic and prognostic ability of salivary MMP-9 for oral squamous cell carcinoma: a pre-\/post-surgery case and matched control study","author":"Shin","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.oor.2023.100018_bib41","first-page":"1","article-title":"Integrative models of histopathological image features and omics data predict survival in head and neck squamous cell carcinoma","author":"Zeng","year":"20208","journal-title":"Front Cell Dev Biol"}],"container-title":["Oral Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772906023000080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772906023000080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T03:16:38Z","timestamp":1737429398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772906023000080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":39,"alternative-id":["S2772906023000080"],"URL":"https:\/\/doi.org\/10.1016\/j.oor.2023.100018","relation":{},"ISSN":["2772-9060"],"issn-type":[{"value":"2772-9060","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a potential prognostic panel of biomarkers for stratification of head and neck squamous cell carcinoma based on HPV status and TP53 mutational status","name":"articletitle","label":"Article Title"},{"value":"Oral Oncology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oor.2023.100018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100018"}}