{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:23:52Z","timestamp":1768350232297,"version":"3.49.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.phrs.2024.107353","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T22:42:37Z","timestamp":1723934557000},"page":"107353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound"],"prefix":"10.1016","volume":"208","author":[{"given":"Iris C.","family":"Salaroglio","sequence":"first","affiliation":[]},{"given":"Denitsa","family":"Stefanova","sequence":"additional","affiliation":[]},{"given":"Ricardo G.","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"Nuno F.B.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Amer","family":"Ahmed","sequence":"additional","affiliation":[]},{"given":"Fabio","family":"Fusi","sequence":"additional","affiliation":[]},{"given":"Virginia","family":"Tzankova","sequence":"additional","affiliation":[]},{"given":"Yordan","family":"Yordanov","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Machuqueiro","sequence":"additional","affiliation":[]},{"given":"Simona","family":"Saponara","sequence":"additional","affiliation":[]},{"given":"Andreia","family":"Valente","sequence":"additional","affiliation":[]},{"given":"Chiara","family":"Riganti","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2024.107353_bib1","unstructured":"World Cancer Research Fund International, Lung Cancer Statistics: https:\/\/www.wcrf.org\/cancer-trends\/lung-cancer-statistics\/ (accessed 15 March 2024)."},{"key":"10.1016\/j.phrs.2024.107353_bib2","first-page":"1","article-title":"The drug resistance mechanisms of five platinum-based antitumor agents","volume":"11","author":"Zhou","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2024.107353_bib3","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/onc.2011.384","article-title":"Molecular mechanisms of cisplatin resistance","volume":"31","author":"Galluzzi","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.phrs.2024.107353_bib4","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.2147\/DDDT.S275007","article-title":"Ruthenium complexes as anticancer agents: a brief history and perspectives","volume":"14","author":"Lee","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.phrs.2024.107353_bib5","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1021\/acs.jmedchem.7b01689","article-title":"Ru(II) compounds: next-generation anticancer metallotherapeutics?","volume":"61","author":"Thota","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phrs.2024.107353_bib6","series-title":"Ruthenium and Iron Metallodrugs: New Inorganic and Organometallic Complexes as Prospective Anticancer Agents, Synthetic Inorganic Chemistry: New Perspectives","first-page":"223","author":"Valente","year":"2021"},{"key":"10.1016\/j.phrs.2024.107353_bib7","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/ejic.201600986","article-title":"Thirty years of the drug candidate NAMI-A and the myths in the field of ruthenium anticancer compounds: a personal perspective","volume":"2017","author":"Alessio","year":"2017","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.phrs.2024.107353_bib8","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1039\/C3SC53243G","article-title":"NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application","volume":"5","author":"Trondl","year":"2014","journal-title":"Chem. Sci."},{"key":"10.1016\/j.phrs.2024.107353_bib9","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1021\/acs.chemrev.8b00211","article-title":"Transition metal complexes and photodynamic therapy from a tumor-centered approach: challenges, opportunities, and highlights from the development of TLD1433","volume":"119","author":"Monro","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.phrs.2024.107353_bib10","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: an evolving paradigm","volume":"13","author":"Holohan","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phrs.2024.107353_bib11","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.2174\/1871520617666171016105704","article-title":"Research progress in reversal of tumor multi-drug resistance via natural products","volume":"17","author":"Guo","year":"2017","journal-title":"Anticancer. Agents Med. Chem."},{"key":"10.1016\/j.phrs.2024.107353_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2021.100778","article-title":"Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance","volume":"58","author":"Valente","year":"2021","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.phrs.2024.107353_bib13","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1021\/jm070039f","article-title":"Development of ruthenium antitumor drugs that overcome multidrug resistance mechanisms","volume":"50","author":"Vock","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phrs.2024.107353_bib14","doi-asserted-by":"crossref","first-page":"80716","DOI":"10.18632\/oncotarget.13032","article-title":"The induction of autophagy against mitochondria-mediated apoptosis in lung cancer cells by a ruthenium (II) imidazole complex","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.phrs.2024.107353_bib15","doi-asserted-by":"crossref","first-page":"18444","DOI":"10.1021\/jacs.9b07225","article-title":"Photo-uncaging of a microtubule-targeted rigidin analogue in hypoxic cancer cells and in a xenograft mouse model","volume":"141","author":"Van Rixel","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phrs.2024.107353_bib16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ebiom.2018.11.047","article-title":"A New Gold(I) Complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growth","volume":"39","author":"Li","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phrs.2024.107353_bib17","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1039\/C8DT00783G","article-title":"Cyclometalated Iridium(Iii) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth: in vivo","volume":"47","author":"He","year":"2018","journal-title":"Dalt. Trans."},{"key":"10.1016\/j.phrs.2024.107353_bib18","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1039\/D1DT03749H","article-title":"Discovery of Thirteen Cobalt(Ii) and Copper(Ii) salicylaldehyde schiff base complexes that induce apoptosis and autophagy in human lung adenocarcinoma A549\/DDP cells and that can overcome cisplatin resistance in vitro and in vivo","volume":"51","author":"Chen","year":"2022","journal-title":"Dalt. Trans."},{"key":"10.1016\/j.phrs.2024.107353_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2021.129963","article-title":"Antitumoral synergism between a copper(II) complex and cisplatin improves in vitro and in vivo anticancer activity against melanoma, lung and breast cancer cells","volume":"1865","author":"Mariani","year":"2021","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.phrs.2024.107353_bib20","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1039\/D0QI01344G","article-title":"Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds","volume":"8","author":"Teixeira","year":"2021","journal-title":"Inorg. Chem. Front."},{"key":"10.1016\/j.phrs.2024.107353_bib21","doi-asserted-by":"crossref","first-page":"14080","DOI":"10.1021\/acs.jmedchem.3c01120","article-title":"Fighting multidrug resistance with ruthenium\u2212cyclopentadienyl compounds: unveiling the mechanism of P\u2011gp inhibition","volume":"66","author":"Teixeira","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phrs.2024.107353_bib22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ejmech.2018.12.022","article-title":"Unprecedented inhibition of P-Gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand","volume":"163","author":"C\u00f4rte-Real","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phrs.2024.107353_bib23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tiv.2017.07.015","article-title":"Toxicology in vitro in vitro vascular toxicity of tariquidar, a potential tool for in vivo PET studies","volume":"44","author":"Durante","year":"2017","journal-title":"Toxicol. Vitr"},{"key":"10.1016\/j.phrs.2024.107353_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.phrs.2024.107353_bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/jfb5020043","article-title":"Functional biomaterials HaCaT keratinocytes response on antimicrobial atelocollagen substrates: extent of cytotoxicity, cell viability and proliferation","volume":"5","author":"L\u00f3pez-Garc\u00eda","year":"2014","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.phrs.2024.107353_bib26","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nprot.2008.75","article-title":"Neutral red uptake assay for the estimation of cell viability\/cytotoxicity","volume":"3","author":"Repetto","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phrs.2024.107353_bib27","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.phrs.2024.107353_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-1596-7-15","article-title":"Efficacy of ImageJ in the assessment of apoptosis","volume":"7","author":"Helmy","year":"2012","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.phrs.2024.107353_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2121-8-11","article-title":"Tert-butylhydroperoxide\u2013characterization of morphological features of cell death","volume":"8","author":"Sard\u00e3o","year":"2007","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.phrs.2024.107353_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms18112393","article-title":"Dynamic reorganization of the cytoskeleton during apoptosis: the two coffins hypothesis","volume":"18","author":"Povea-Cabello","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phrs.2024.107353_bib31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/15376516.2019.1695303","article-title":"Hep G2 Cell culture confluence measurement in phase contrast micrographs \u2013 a user-friendly, open-source software-based approach","volume":"30","author":"Yordanov","year":"2020","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.phrs.2024.107353_bib32","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"Historical commentary nih image to imagej: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phrs.2024.107353_bib33","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/10590500902885684","article-title":"8-hydroxy-2\u2032 -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis","volume":"27","author":"Valavanidis","year":"2009","journal-title":"J. Environ. Sci. Health C\u00a0Environ. Carcinog. Ecotoxicol.\u00a0Rev."},{"key":"10.1016\/j.phrs.2024.107353_bib34","doi-asserted-by":"crossref","first-page":"31461","DOI":"10.18632\/oncotarget.5058","article-title":"Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells","volume":"6","author":"Kopecka","year":"2015","journal-title":"Oncotarget"},{"issue":"73","key":"10.1016\/j.phrs.2024.107353_bib35","doi-asserted-by":"crossref","DOI":"10.3791\/50166-v","article-title":"Ex vivo red blood cell hemolysis assay for the evaluation of PH-responsive endosomolytic agents for cytosolic delivery of biomacromolecular drugs","author":"Evans","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.phrs.2024.107353_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2144\/btn-2018-0132","article-title":"Rapid quantification of cellular proliferation and migration using ImageJ","volume":"66","author":"Venter","year":"2019","journal-title":"Biotechniques"},{"key":"10.1016\/j.phrs.2024.107353_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104404","article-title":"Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators","volume":"105","author":"Carullo","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phrs.2024.107353_bib38","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/apha.12282","article-title":"L-Type Ca 2+ channel current characteristics are preserved in rat tail artery myocytes after one-day storage","volume":"211","author":"Mugnai","year":"2014","journal-title":"Acta Physiol."},{"key":"10.1016\/j.phrs.2024.107353_bib39","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/bph.13369","article-title":"Functional, electrophysiological and molecular docking analysis of the modulation of Cav1.2 channels in rat vascular myocytes by murrayafoline A","volume":"173","author":"Saponara","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2024.107353_bib40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.vph.2015.11.041","article-title":"The vasodilator papaverine stimulates L-Type Ca2+ current in rat tail artery myocytes via a PKA-dependent mechanism","volume":"76","author":"Fusi","year":"2016","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.phrs.2024.107353_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175786","article-title":"Dynamin-independent CaV1.2 and KCa1.1 channels regulation and vascular tone modulation by the mitochondrial fission inhibitors dynasore and dyngo-4a","volume":"951","author":"Ahmed","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2024.107353_bib42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00280-007-0488-6","article-title":"Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells","volume":"61","author":"Fusi","year":"2008","journal-title":"Cancer Chemother. Pharm."},{"key":"10.1016\/j.phrs.2024.107353_bib43","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2024.107353_bib44","doi-asserted-by":"crossref","first-page":"5.6.1","DOI":"10.1002\/cpbi.3","article-title":"Comparative protein structure modeling using MODELLER","volume":"54","author":"Webb","year":"2016","journal-title":"Curr. Protoc. Bioinforma."},{"key":"10.1016\/j.phrs.2024.107353_bib45","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/j.phrs.2024.107353_bib46","unstructured":"L.L.C. Schr\u00f6dinger, The PyMOL Molecular Graphics System, v.1.8, 2015 (https:\/\/www.pymol.org\/)."},{"key":"10.1016\/j.phrs.2024.107353_bib47","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: New docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.phrs.2024.107353_bib48","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phrs.2024.107353_bib49","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1021\/ar000033j","article-title":"Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models","volume":"33","author":"Kollman","year":"2000","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.phrs.2024.107353_bib50","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1016\/0040-4020(80)80168-2","article-title":"Iterative partial equalization of orbital electronegativity-a rapid access to atomic charges","volume":"36","author":"Gasteiger","year":"1980","journal-title":"Terahedron"},{"key":"10.1016\/j.phrs.2024.107353_bib51","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1039\/D0DT00955E","article-title":"Novel \"ruthenium cyclopentadienyl\"-peptide conjugate complexes against human FGFR(+) breast cancer","volume":"49","author":"Franco Machado","year":"2020","journal-title":"Dalton Trans."},{"key":"10.1016\/j.phrs.2024.107353_bib52","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s13046-022-02447-6","article-title":"Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer","volume":"41","author":"Salaroglio","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2024.107353_bib53","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3390\/cells9041033","article-title":"Insights into P-glycoprotein inhibitors: new inducers of immunogenic cell death","volume":"9","author":"Kopecka","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phrs.2024.107353_bib54","unstructured":"ASTM F756\u201300, Standard Practice for Assessment of Hemolytic Properties of Materials (ASTM International), West Conshohocken, PA, USA, 2004."},{"key":"10.1016\/j.phrs.2024.107353_bib55","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.3390\/ijms17081254","article-title":"Pharmacological activities of ruthenium complexes related to their NO scavenging properties","volume":"17","author":"Castellarin","year":"2016","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.phrs.2024.107353_bib56","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2174\/1871520616666160922165133","article-title":"In vivo performance of a ruthenium-cyclopentadienyl compound in an orthotopic triple negative breast cancer model","volume":"17","author":"Mendes","year":"2017","journal-title":"Anticancer, Agents Med. Chem."},{"key":"10.1016\/j.phrs.2024.107353_bib57","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3390\/pharmaceutics14020292","article-title":"Targeted self-emulsifying drug delivery systems to restore docetaxel sensitivity in resistant tumors","volume":"14","author":"Campani","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phrs.2024.107353_bib58","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1080\/08927014.2020.1771317","article-title":"Antimicrobial activity and antibiotic synergy of a biphosphinic ruthenium complex against clinically relevant bacteria","volume":"36","author":"Andrade","year":"2020","journal-title":"Biofouling"},{"key":"10.1016\/j.phrs.2024.107353_bib59","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.1039\/D3DT00059A","article-title":"New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders","volume":"52","author":"Gouveia J\u00fanior","year":"2023","journal-title":"Dalton Trans."},{"key":"10.1016\/j.phrs.2024.107353_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2023.112436","article-title":"Lead to hit ruthenium-cyclopentadienyl anticancer compounds: cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling","volume":"251","author":"Maximiano","year":"2024","journal-title":"J. Inorg. Biochem."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824002986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661824002986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T23:11:40Z","timestamp":1726787500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661824002986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":60,"alternative-id":["S1043661824002986"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107353","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2024.107353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107353"}}