{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:59:25Z","timestamp":1791460765049,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2024GXNSFAA010175"],"award-info":[{"award-number":["2024GXNSFAA010175"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22267002"],"award-info":[{"award-number":["22267002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sensors and Actuators B: Chemical"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.snb.2026.140934","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:41:49Z","timestamp":1789688509000},"page":"140934","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hepatic-targeting dual-channel fluorescent probe activated by \u03b2-Gal and ONOO- for tracking liver senescence and senolysis process"],"prefix":"10.1016","volume":"470","author":[{"given":"Hongyuan","family":"Quan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3917-8327","authenticated-orcid":false,"given":"Jianyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.snb.2026.140934_bib1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41575-024-00913-4","article-title":"Cell senescence in liver diseases: pathological mechanism and theranostic opportunity","volume":"21","author":"Sanfeliu-Redondo","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.snb.2026.140934_bib2","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1097\/CM9.0000000000003439","article-title":"Navigating the complex role of senescence in liver disease","volume":"137","author":"Li","year":"2024","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.snb.2026.140934_bib3","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41580-024-00738-8","article-title":"SenNet recommendations for detecting senescent cells in different tissues","volume":"25","author":"Suryadevara","year":"2024","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.snb.2026.140934_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2020.151108","article-title":"Aging of the cells: insight into cellular senescence and detection methods","volume":"99","author":"Mohamad Kamal","year":"2020","journal-title":"Eur. J. Cell. Biol."},{"key":"10.1016\/j.snb.2026.140934_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103805","article-title":"Probing mitochondrial peroxynitrite biogenesis by a N-morpholinoarylimine-based iridium(III) complex in drug-induced liver cells","volume":"86","author":"Kong","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.snb.2026.140934_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00018-022-04186-5","article-title":"ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NF-\u03baB activation","volume":"79","author":"Kim","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.snb.2026.140934_bib7","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.freeradbiomed.2025.08.006","article-title":"Mitochondrial dysfunction-mediated hepatocyte senescence is involved in cholestatic liver injury","volume":"239","author":"Tong","year":"2025","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.snb.2026.140934_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-59745-361-5_3","article-title":"Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay","volume":"371","author":"Itahana","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.snb.2026.140934_bib9","first-page":"1285","article-title":"Revolutionizing senescence detection: advancements from traditional methods to cutting-edge techniques","volume":"16","author":"Xiao","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.snb.2026.140934_bib10","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1039\/C0AN00625D","article-title":"GC-MS and HPLC methods for peroxynitrite (ONOO- and O\u00b9\u2075NOO\u207b) analysis: a study on stability, decomposition to nitrite and nitrate, laboratory synthesis, and formation of peroxynitrite from S-nitrosoglutathione (GSNO) and KO\u2082","volume":"136","author":"Tsikas","year":"2011","journal-title":"Analyst"},{"key":"10.1016\/j.snb.2026.140934_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2018.02.017","article-title":"Fluorescence and chemiluminescence approaches for peroxynitrite detection","volume":"128","author":"Prolo","year":"2018","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.snb.2026.140934_bib12","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1021\/acsabm.4c00185","article-title":"Triple sensing modes for triggered \u03b2-galactosidase activity assays based on kaempferol-deduced silicon nanoparticles and biological imaging of MCF-7 breast cancer cells","volume":"7","author":"Iradukunda","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.snb.2026.140934_bib13","doi-asserted-by":"crossref","DOI":"10.1039\/D6AY00927A","article-title":"A ratiometric fluorescent probe for the detection of peroxynitrite in environmental and plant systems","author":"Geng","year":"2026","journal-title":"Anal. Methods"},{"issue":"2","key":"10.1016\/j.snb.2026.140934_bib14","doi-asserted-by":"crossref","DOI":"10.48130\/targetome-0026-0016","article-title":"A multisite bridging mediated lateral flow immunoassay for the enhanced detection of mosquito-borne viruses","volume":"2","author":"Nie","year":"2026","journal-title":"Targetome"},{"key":"10.1016\/j.snb.2026.140934_bib15","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1021\/acs.chemrev.3c00776","article-title":"Fluorescent probes for disease diagnosis","volume":"124","author":"Wang","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.snb.2026.140934_bib16","doi-asserted-by":"crossref","first-page":"13800","DOI":"10.1021\/acs.analchem.1c02391","article-title":"Aging diagnostic probe for research on aging and evaluation of anti-aging drug efficacy","volume":"93","author":"Li","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.snb.2026.140934_bib17","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1021\/acs.analchem.3c00131","article-title":"\u03b2-Galactosidase-activatable Nile blue-based NIR senoprobe for the real-time detection of cellular senescence","volume":"95","author":"Lozano-Torres","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.snb.2026.140934_bib18","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1021\/acs.analchem.2c00239","article-title":"An activatable NIR probe for the detection and elimination of senescent cells","volume":"94","author":"Yang","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.snb.2026.140934_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.121879","article-title":"Rational design of near-infrared ratiometric fluorescent probes for real-time tracking of \u03b2-galactosidase in vivo","volume":"285","author":"Chen","year":"2023","journal-title":"Spectrochim. Acta Part. A"},{"key":"10.1016\/j.snb.2026.140934_bib20","doi-asserted-by":"crossref","first-page":"15591","DOI":"10.1021\/acs.analchem.9b03639","article-title":"An ultrasensitivity fluorescent probe based on the ICT-FRET dual mechanisms for imaging \u03b2-galactosidase in vitro and ex vivo","volume":"91","author":"Kong","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.snb.2026.140934_bib21","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1039\/D2TB02568J","article-title":"A therapeutic probe for detecting and inhibiting ONOO- in senescent cells","volume":"11","author":"Huang","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.snb.2026.140934_bib22","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1021\/acs.analchem.4c05160","article-title":"Simultaneous detection of hydrogen sulfide and peroxynitrite dysregulation with a sequentially activated fluorescent probe in ulcerative colitis disease","volume":"97","author":"Chen","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.snb.2026.140934_bib23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1021\/acschemneuro.4c00770","article-title":"Visualizing endoplasmic reticulum stress and autophagy in Alzheimer's model cells by a peroxynitrite-responsive AIEgen fluorescent probe","volume":"16","author":"Huang","year":"2025","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.snb.2026.140934_bib24","doi-asserted-by":"crossref","first-page":"20161","DOI":"10.1021\/acs.analchem.4c03759","article-title":"A mitochondria-targeting and peroxynitrite-activatable ratiometric fluorescent probe for precise tracking of oxidative stress-induced mitophagy","volume":"96","author":"Chai","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.snb.2026.140934_bib25","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s43630-024-00565-y","article-title":"A fluorescent probe based on cyclochalcone for detecting peroxynitrite","volume":"23","author":"Liu","year":"2024","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.snb.2026.140934_bib26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1053\/hupa.2001.22747","article-title":"Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas","volume":"32","author":"Paradis","year":"2001","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.snb.2026.140934_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-97073-1","article-title":"Rapid fluorescence imaging of human hepatocellular carcinoma using the \u03b2-galactosidase-activatable fluorescence probe SPiDER-\u03b2Gal","volume":"11","author":"Ogawa","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.snb.2026.140934_bib28","doi-asserted-by":"crossref","first-page":"9225","DOI":"10.1021\/acs.chemrev.3c00892","article-title":"Ex Tenebris Lux: illuminating reactive oxygen and nitrogen species with small molecule probes","volume":"124","author":"Cabello","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.snb.2026.140934_bib29","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1039\/D5SC00103J","article-title":"A dual-enzyme activated fluorescent probe for precise identification of tumor senescence","volume":"16","author":"Luo","year":"2025","journal-title":"Chem. Sci."},{"key":"10.1016\/j.snb.2026.140934_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2026.130253","article-title":"Dual-channel fluorescent probes enable synchronous tracking of peroxynitrite and cysteine in mitochondrial redox dynamics","volume":"311","author":"Liu","year":"2027","journal-title":"Talanta"},{"key":"10.1016\/j.snb.2026.140934_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2026.140260","article-title":"Smart fluorescent probe for dual-channel imaging of pH and peroxynitrite in cell membranes, tumors, and acute kidney injury","volume":"466","author":"Zhang","year":"2026","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.snb.2026.140934_bib32","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1021\/acs.biomac.2c01329","article-title":"Glycopolymers mediate suicide gene therapy in ASGPR-expressing hepatocellular carcinoma cells in tandem with docetaxel","volume":"24","author":"Santo","year":"2023","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.snb.2026.140934_bib33","doi-asserted-by":"crossref","first-page":"11920","DOI":"10.1021\/acs.jmedchem.0c01160","article-title":"7-Hydroxycoumarins are affinity-based fluorescent probes for competitive binding studies of macrophage migration inhibitory factor","volume":"63","author":"Xiao","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.snb.2026.140934_bib34","first-page":"712A","article-title":"Limit of detection. A closer look at the IUPAC definition","volume":"55","author":"Long","year":"1983","journal-title":"Anal. Chem."},{"key":"10.1016\/j.snb.2026.140934_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111372","article-title":"D-galactose-induced liver aging model: its underlying mechanisms and potential therapeutic interventions","volume":"150","author":"Azman","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.snb.2026.140934_bib36","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1474-9726.2006.00199.x","article-title":"Senescence-associated \u03b2-galactosidase is lysosomal \u03b2-galactosidase","volume":"5","author":"Lee","year":"2006","journal-title":"Aging Cell."},{"key":"10.1016\/j.snb.2026.140934_bib37","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.4049\/jimmunol.160.6.3031","article-title":"Inhibition of inducible nitric oxide synthase prevents LPS-induced acute lung injury in dogs","volume":"160","author":"Numata","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.snb.2026.140934_bib38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.snb.2026.140934_bib39","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/gerona\/glab002","article-title":"Senolytic combination of dasatinib and quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice","volume":"76","author":"Saccon","year":"2021","journal-title":"J. Gerontol. A"},{"key":"10.1016\/j.snb.2026.140934_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/837104","article-title":"Quercetin reduces inflammatory responses in LPS-stimulated cardiomyoblasts","volume":"2012","author":"Angeloni","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.snb.2026.140934_bib41","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuint.2015.07.001","article-title":"Caffeine prevents D-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain","volume":"90","author":"Ullah","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.snb.2026.140934_bib42","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1248\/bpb.b12-00238","article-title":"Effect of Colla Corii Asini (E\u2032jiao) on D-galactose induced aging mice","volume":"35","author":"Wang","year":"2012","journal-title":"Biol. Pharm. Bull."}],"container-title":["Sensors and Actuators B: Chemical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925400526015133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925400526015133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:35:25Z","timestamp":1791459325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925400526015133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":42,"alternative-id":["S0925400526015133"],"URL":"https:\/\/doi.org\/10.1016\/j.snb.2026.140934","relation":{},"ISSN":["0925-4005"],"issn-type":[{"value":"0925-4005","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic-targeting dual-channel fluorescent probe activated by \u03b2-Gal and ONOO- for tracking liver senescence and senolysis process","name":"articletitle","label":"Article Title"},{"value":"Sensors and Actuators B: Chemical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.snb.2026.140934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"140934"}}