{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:48:57Z","timestamp":1791906537778,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752269"],"award-info":[{"award-number":["2024M752269"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370932"],"award-info":[{"award-number":["82370932"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["RD-02-202506"],"award-info":[{"award-number":["RD-02-202506"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC1588"],"award-info":[{"award-number":["2024NSFSC1588"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2024YFFK0204"],"award-info":[{"award-number":["2024YFFK0204"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.stemcr.2026.103063","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:02:54Z","timestamp":1788447774000},"page":"103063","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["SIRT1 promotes endothelial activity and osteogenesis in vitro and ameliorates age-related skeletal regeneration defects in vivo"],"prefix":"10.1016","volume":"21","author":[{"given":"Shibo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanghang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhuo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-1097","authenticated-orcid":false,"given":"En","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2026.103063_bib1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/hpm.2845","article-title":"The causes of aging and relationship between aging and health expenditure: An econometric causality analysis for Turkey","volume":"35","author":"Boz","year":"2020","journal-title":"Int. J. Health Plann. Manage."},{"key":"10.1016\/j.stemcr.2026.103063_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073553","article-title":"Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics","volume":"22","author":"Chandra","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.stemcr.2026.103063_bib3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tem.2013.12.001","article-title":"SIRT1 and other sirtuins in metabolism","volume":"25","author":"Chang","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.stemcr.2026.103063_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2019.07.021","article-title":"Deacetylation of \u03b2-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells","volume":"463","author":"Chen","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.stemcr.2026.103063_bib5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.stemcr.2020.06.007","article-title":"Gli1(+) Cells Couple with Type H Vessels and Are Required for Type H Vessel Formation","volume":"15","author":"Chen","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103063_bib6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.freeradbiomed.2019.10.412","article-title":"Melatonin restores the osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells by preserving SIRT1-mediated intracellular antioxidant properties","volume":"146","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.stemcr.2026.103063_bib7","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.stem.2021.01.010","article-title":"Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging","volume":"28","author":"Deng","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2026.103063_bib8","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1007\/s00198-016-3536-4","article-title":"Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture","volume":"27","author":"El-Haj","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.stemcr.2026.103063_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101915","article-title":"Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis","volume":"41","author":"Guo","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.stemcr.2026.103063_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13046-022-02266-9","article-title":"HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of \u03b2-catenin-FGF18 pathway","volume":"41","author":"Guo","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.stemcr.2026.103063_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s12884-026-09502-6","article-title":"Factors associated with pharmacologic serum concentration of magnesium and corresponding obstetric outcomes among women with severe preeclampsia at Iringa regional referral hospital","author":"Kileo","year":"2026","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.stemcr.2026.103063_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2121-9-60","article-title":"Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells","volume":"9","author":"Kretlow","year":"2008","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.stemcr.2026.103063_bib13","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/acel.12260","article-title":"Identification of serum sirtuins as novel noninvasive protein markers for frailty","volume":"13","author":"Kumar","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.stemcr.2026.103063_bib14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.103063_bib15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature17638","article-title":"Age-dependent modulation of vascular niches for haematopoietic stem cells","volume":"532","author":"Kusumbe","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.103063_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jbspin.2010.09.009","article-title":"Bone vascularization and remodeling","volume":"77","author":"Lafage-Proust","year":"2010","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.stemcr.2026.103063_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13596","article-title":"SIRT1 activation promotes bone repair by enhancing the coupling of type H vessel formation and osteogenesis","volume":"57","author":"Liu","year":"2024","journal-title":"Cell Prolif."},{"key":"10.1016\/j.stemcr.2026.103063_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152868","article-title":"A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice","volume":"132","author":"Luo","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.stemcr.2026.103063_bib19","doi-asserted-by":"crossref","first-page":"426","DOI":"10.7150\/thno.34126","article-title":"Type H blood vessels in bone modeling and remodeling","volume":"10","author":"Peng","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.stemcr.2026.103063_bib20","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1359\/jbmr.070415","article-title":"Aging reduces skeletal blood flow, endothelium-dependent vasodilation, and NO bioavailability in rats","volume":"22","author":"Prisby","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.stemcr.2026.103063_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13601","article-title":"Blood flow controls bone vascular function and osteogenesis","volume":"7","author":"Ramasamy","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2026.103063_bib22","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s44161-022-00139-0","article-title":"Oestrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause","volume":"1","author":"Rodrigues","year":"2022","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.stemcr.2026.103063_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.abb.2014.07.006","article-title":"Role of angiogenesis in bone repair","volume":"561","author":"Saran","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.stemcr.2026.103063_bib35","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.stemcr.2026.103063_bib24","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nature08683","article-title":"DNMT1 maintains progenitor function in self-renewing somatic tissue","volume":"463","author":"Sen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.103063_bib25","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10753-020-01242-9","article-title":"Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation","volume":"43","author":"Singh","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.stemcr.2026.103063_bib26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","article-title":"An overview and management of osteoporosis","volume":"4","author":"S\u00f6zen","year":"2017","journal-title":"Eur. J. Rheumatol."},{"key":"10.1016\/j.stemcr.2026.103063_bib27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/cvr\/cvu220","article-title":"Intracellular NAMPT-NAD+-SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors","volume":"104","author":"Wang","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.stemcr.2026.103063_bib28","doi-asserted-by":"crossref","first-page":"8653","DOI":"10.1002\/jcp.29709","article-title":"Specific inhibition of FAK signaling attenuates subchondral bone deterioration and articular cartilage degeneration during osteoarthritis pathogenesis","volume":"235","author":"Wu","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.stemcr.2026.103063_bib29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41591-018-0020-z","article-title":"Targeting skeletal endothelium to ameliorate bone loss","volume":"24","author":"Xu","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2026.103063_bib30","doi-asserted-by":"crossref","first-page":"15050","DOI":"10.18632\/aging.103569","article-title":"Establishing a density-based method to separate proliferating and senescent cells from bone marrow stromal cells","volume":"12","author":"Xu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.stemcr.2026.103063_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.218193","article-title":"Cytoplasmic SIRT1 enhances the stemness of polyploid giant cancer cells by promoting \u03b2-catenin protein stability and nuclear accumulation in ovarian carcinoma upon neoadjuvant chemotherapy","volume":"639","author":"Xu","year":"2026","journal-title":"Cancer Lett."},{"key":"10.1016\/j.stemcr.2026.103063_bib32","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.stemcr.2026.103063_bib36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.stemcr.2026.103063_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13046-019-1031-4","article-title":"ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway","volume":"38","author":"Yu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126002742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126002742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:20:48Z","timestamp":1791904848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671126002742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2213671126002742"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.103063","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIRT1 promotes endothelial activity and osteogenesis in vitro and ameliorates age-related skeletal regeneration defects in vivo","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.103063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Society for Stem Cell Research.","name":"copyright","label":"Copyright"}],"article-number":"103063"}}