{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:09:35Z","timestamp":1790197775762,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013263","name":"The National Organization for health","doi-asserted-by":"publisher","award":["51418"],"award-info":[{"award-number":["51418"]}],"id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013263","name":"The National Organization for health","doi-asserted-by":"publisher","award":["43080"],"award-info":[{"award-number":["43080"]}],"id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer&apos;s Fund","doi-asserted-by":"publisher","award":["282952"],"award-info":[{"award-number":["282952"]}],"id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012446","name":"Akershus University Hospital","doi-asserted-by":"publisher","award":["261973"],"award-info":[{"award-number":["261973"]}],"id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012446","name":"Akershus University Hospital","doi-asserted-by":"publisher","award":["269901"],"award-info":[{"award-number":["269901"]}],"id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012446","name":"Akershus University Hospital","doi-asserted-by":"publisher","award":["390612"],"award-info":[{"award-number":["390612"]}],"id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012446","name":"Akershus University Hospital","doi-asserted-by":"publisher","award":["263928"],"award-info":[{"award-number":["263928"]}],"id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012446","name":"Akershus University Hospital","doi-asserted-by":"publisher","award":["262960"],"award-info":[{"award-number":["262960"]}],"id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971327"],"award-info":[{"award-number":["81971327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028897","name":"Wellcome Leap","doi-asserted-by":"publisher","award":["104617"],"award-info":[{"award-number":["104617"]}],"id":[{"id":"10.13039\/100028897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["262175"],"award-info":[{"award-number":["262175"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["334361"],"award-info":[{"award-number":["334361"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","award":["2020001"],"award-info":[{"award-number":["2020001"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","award":["2023093"],"award-info":[{"award-number":["2023093"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","award":["2021021"],"award-info":[{"award-number":["2021021"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004785","name":"NordForsk","doi-asserted-by":"publisher","award":["119986"],"award-info":[{"award-number":["119986"]}],"id":[{"id":"10.13039\/501100004785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.tem.2026.09.003","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:10:03Z","timestamp":1790107803000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["NAD+ augmentation in brain aging: hype, hope, or emerging reality?"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-1487","authenticated-orcid":false,"given":"He-Ling","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-7536","authenticated-orcid":false,"given":"Jianying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-7202","authenticated-orcid":false,"given":"Evandro Fei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2026.09.003_bb0005","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1038\/s43587-025-00947-6","article-title":"Emerging strategies, applications and challenges of targeting NAD(+) in the clinic","volume":"5","author":"Zhang","year":"2025","journal-title":"Nat. Aging"},{"key":"10.1016\/j.tem.2026.09.003_bb0010","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.cmet.2023.04.012","article-title":"The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging","volume":"35","author":"Wang","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2026.09.003_bb0015","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s43587-026-01108-z","article-title":"Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer\u2019s disease pathology","volume":"6","author":"Pan","year":"2026","journal-title":"Nat. Aging"},{"key":"10.1016\/j.tem.2026.09.003_bb0020","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41419-024-06770-y","article-title":"Targeting the autophagy\u2013NAD axis protects against cell death in Niemann\u2013Pick type C1 disease models","volume":"15","author":"Kataura","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tem.2026.09.003_bb0025","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.cmet.2022.02.001","article-title":"The NADPARK study: a randomized phase I trial of nicotinamide riboside supplementation in Parkinson\u2019s disease","volume":"34","author":"Brakedal","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2026.09.003_bb0030","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13754","article-title":"Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin","volume":"22","author":"Vreones","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2026.09.003_bb0035","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/s42255-026-01537-5","article-title":"Human whole-blood NAD(+) levels do not vary with age or lifestyle interventions","volume":"8","author":"Tretowicz","year":"2026","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tem.2026.09.003_bb0040","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41580-024-00752-w","article-title":"Regulation of and challenges in targeting NAD(+) metabolism","volume":"25","author":"Migaud","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tem.2026.09.003_bb0045","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1038\/s42255-024-01174-w","article-title":"Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD","volume":"6","author":"Hoyland","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tem.2026.09.003_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27135652","article-title":"Transcriptional profiling shows dampening of interferon gene signatures by NAD+ augmentation in ataxia-telangiectasia","volume":"27","author":"Suaste","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tem.2026.09.003_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41514-023-00098-1","article-title":"Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus","volume":"9","author":"Johnson","year":"2023","journal-title":"NPJ Aging"},{"key":"10.1016\/j.tem.2026.09.003_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2026.114764","article-title":"The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation","volume":"29","author":"Berven","year":"2026","journal-title":"iScience"},{"key":"10.1016\/j.tem.2026.09.003_bb0065","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1038\/s41467-026-70965-4","article-title":"Therapeutic potential of dihydronicotinamide riboside (NRH) on obesity and glucose intolerance in mice","volume":"17","author":"Rumpler","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2026.09.003_bb0070","article-title":"Cognitive and Alzheimer\u2019s disease biomarker effects of oral nicotinamide riboside (NR) supplementation in older adults with subjective cognitive decline and mild cognitive impairment","volume":"11","author":"Wu","year":"2025","journal-title":"Alzheimers Dement. (N Y)"},{"key":"10.1016\/j.tem.2026.09.003_bb0075","doi-asserted-by":"crossref","first-page":"6895","DOI":"10.1007\/s11357-025-01815-2","article-title":"Nicotinamide riboside combined with exercise to treat hypertension in middle-aged and older adults: a pilot randomized clinical trial","volume":"47","author":"Lin","year":"2025","journal-title":"Geroscience"}],"container-title":["Trends in Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276026002420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276026002420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:51:19Z","timestamp":1790196679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276026002420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":15,"alternative-id":["S1043276026002420"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2026.09.003","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NAD+ augmentation in brain aging: hype, hope, or emerging reality?","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2026.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}