{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:49:48Z","timestamp":1791578988802,"version":"4.3.4"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR54186\/BMS\/85\/469\/2024"],"award-info":[{"award-number":["BT\/PR54186\/BMS\/85\/469\/2024"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017220","name":"Regional Centre for Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tem.2026.09.012","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:46:13Z","timestamp":1791467173000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Running on ROS: redefining metabolic adaptation and healthy aging"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9832-8886","authenticated-orcid":false,"given":"Jaydeep","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahima","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-6094","authenticated-orcid":false,"given":"Sam J.","family":"Mathew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2026.09.012_bb0005","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41572-024-00550-w","article-title":"Sarcopenia","volume":"10","author":"Sayer","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.tem.2026.09.012_bb0010","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tem.2026.09.012_bb0015","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl4988","article-title":"Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance","volume":"7","author":"Xirouchaki","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tem.2026.09.012_bb0020","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adz1953","article-title":"A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging","volume":"12","author":"Xirouchaki","year":"2026","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tem.2026.09.012_bb0025","doi-asserted-by":"crossref","DOI":"10.1172\/JCI162533","article-title":"Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity","volume":"134","author":"Greatorex","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.09.012_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah4477","article-title":"Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes","volume":"9","author":"Axelsson","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tem.2026.09.012_bb0035","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aed2478","article-title":"The skeletal muscle slow myosin heavy chain regulates mammalian metabolic homeostasis through the NRF2 pathway","volume":"12","author":"Sharma","year":"2026","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tem.2026.09.012_bb0040","doi-asserted-by":"crossref","DOI":"10.1126\/science.adr8589","article-title":"Running a genetic stop sign accelerates oxygen metabolism and energy production in horses","volume":"387","author":"Castiglione","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.tem.2026.09.012_bb0045","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1038\/s41467-020-16129-4","article-title":"Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds","volume":"11","author":"Castiglione","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2026.09.012_bb0050","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1073\/pnas.0903485106","article-title":"Antioxidants prevent health-promoting effects of physical exercise in humans","volume":"106","author":"Ristow","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Trends in Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276026002511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276026002511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:03:15Z","timestamp":1791576195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276026002511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"alternative-id":["S1043276026002511"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2026.09.012","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Running on ROS: redefining metabolic adaptation and healthy aging","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2026.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}