{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:37:53Z","timestamp":1793317073817,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,171,759"],"award-info":[{"award-number":["82,171,759"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,572,086"],"award-info":[{"award-number":["82,572,086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,572,038"],"award-info":[{"award-number":["82,572,038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,101,873"],"award-info":[{"award-number":["82,101,873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,402,064"],"award-info":[{"award-number":["82,402,064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,503,126"],"award-info":[{"award-number":["82,503,126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2408085QH268"],"award-info":[{"award-number":["2408085QH268"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2M-5-035"],"award-info":[{"award-number":["2M-5-035"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.tranon.2026.102750","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:33:18Z","timestamp":1775154798000},"page":"102750","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["EGR1 lactylation induces tumor cell senescence and immunosuppressive microenvironment in intrahepatic cholangiocarcinoma"],"prefix":"10.1016","volume":"67","author":[{"given":"Yuan","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfa","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2372-9545","authenticated-orcid":false,"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5264-4215","authenticated-orcid":false,"given":"Ziyan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-0774","authenticated-orcid":false,"given":"Mu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinren","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7949-4020","authenticated-orcid":false,"given":"Qiuyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tranon.2026.102750_bib0001","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jhep.2019.10.009","article-title":"Systemic therapies for intrahepatic cholangiocarcinoma","volume":"72","author":"Kelley","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tranon.2026.102750_bib0002","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejca.2021.11.023","article-title":"Global, regional and national burden of primary liver cancer by subtype","volume":"161","author":"Rumgay","year":"2022","journal-title":"Eur. J. Cancer"},{"issue":"2","key":"10.1016\/j.tranon.2026.102750_bib0003","first-page":"198","article-title":"Advances in the treatment of intrahepatic cholangiocarcinoma: an overview of the current and future therapeutic landscape for clinicians","volume":"73","author":"Moris","year":"2023","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.tranon.2026.102750_bib0004","doi-asserted-by":"crossref","first-page":"270","DOI":"10.21037\/hbsn.2018.03.16","article-title":"Cohort contributions to trends in the incidence and mortality of intrahepatic cholangiocarcinoma","volume":"7","author":"Beal","year":"2018","journal-title":"Hepatobiliary Surg. Nutr."},{"issue":"7","key":"10.1016\/j.tranon.2026.102750_bib0005","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: from physiology to pathology","volume":"15","author":"Mu\u00f1oz-Esp\u00edn","year":"2014","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"6702","key":"10.1016\/j.tranon.2026.102750_bib0006","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.adj7050","article-title":"Cellular senescence in normal physiology","volume":"384","author":"de Magalh\u00e3es","year":"2024","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.tranon.2026.102750_bib0007","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12943-024-02096-7","article-title":"Cellular senescence and sasp in tumor progression and therapeutic opportunities","volume":"23","author":"Dong","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tranon.2026.102750_bib0008","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2025-334861","article-title":"Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome","author":"Milardi","year":"2025","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.tranon.2026.102750_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167276","article-title":"Single-cell analysis reveals hypoxia-induced immunosuppressive microenvironment in intrahepatic cholangiocarcinoma","volume":"1870","author":"Liang","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.tranon.2026.102750_bib0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41389-017-0011-9","article-title":"The hypoxic tumour microenvironment","volume":"7","author":"Petrova","year":"2018","journal-title":"Oncogenesis"},{"issue":"17","key":"10.1016\/j.tranon.2026.102750_bib0011","article-title":"Idh mutation subgroup status associates with intratumor heterogeneity and the tumor microenvironment in intrahepatic cholangiocarcinoma","volume":"8","author":"Xiang","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"issue":"7","key":"10.1016\/j.tranon.2026.102750_bib0012","article-title":"Single-cell and spatial transcriptomics delineate the microstructure and immune landscape of intrahepatic cholangiocarcinoma in the leading-edge area","volume":"12","author":"Zuyin","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"issue":"4","key":"10.1016\/j.tranon.2026.102750_bib0013","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1053\/j.gastro.2013.01.001","article-title":"Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes","volume":"144","author":"Sia","year":"2013","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.tranon.2026.102750_bib0014","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s12072-019-09954-3","article-title":"Prognostic subclass of intrahepatic cholangiocarcinoma by integrative molecular-clinical analysis and potential targeted approach","volume":"13","author":"Ahn","year":"2019","journal-title":"Hepatol. Int."},{"issue":"10","key":"10.1016\/j.tranon.2026.102750_bib0015","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1158\/2159-8290.CD-17-0368","article-title":"Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma","volume":"7","author":"Jusakul","year":"2017","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.tranon.2026.102750_bib0016","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ccell.2021.12.006","article-title":"Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma","volume":"40","author":"Dong","year":"2022","journal-title":"Cancer Cell."},{"issue":"1","key":"10.1016\/j.tranon.2026.102750_bib0017","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1038\/s41467-022-35291-5","article-title":"Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer","volume":"13","author":"Ma","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2026.102750_bib0018","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"Gene set variation analysis for microarray and rna-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinform."},{"issue":"7","key":"10.1016\/j.tranon.2026.102750_bib0019","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for rna-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"13","key":"10.1016\/j.tranon.2026.102750_bib0020","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.tranon.2026.102750_bib0021","article-title":"Clusterprofiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innov. (Camb)"},{"issue":"12","key":"10.1016\/j.tranon.2026.102750_bib0022","article-title":"Enhancing immuno-oncology investigations through multidimensional decoding of tumor microenvironment with iobr 2.0","volume":"4","author":"Zeng","year":"2024","journal-title":"Cell. Rep. Methods"},{"issue":"12","key":"10.1016\/j.tranon.2026.102750_bib0023","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"issue":"6476","key":"10.1016\/j.tranon.2026.102750_bib0024","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.aax0249","article-title":"Single-cell transcriptional diversity is a hallmark of developmental potential","volume":"367","author":"Gulati","year":"2020","journal-title":"Science"},{"issue":"26","key":"10.1016\/j.tranon.2026.102750_bib0025","doi-asserted-by":"crossref","first-page":"765","DOI":"10.21105\/joss.00765","article-title":"Philentropy: information theory and distance quantification with R","volume":"3","author":"Drost","year":"2018","journal-title":"J. Open Source Softw."},{"issue":"7","key":"10.1016\/j.tranon.2026.102750_bib0026","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-020-0336-2","article-title":"A scalable scenic workflow for single-cell gene regulatory network analysis","volume":"15","author":"Van de Sande","year":"2020","journal-title":"Nat. Protoc."},{"issue":"8","key":"10.1016\/j.tranon.2026.102750_bib0027","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1101\/gr.240663.118","article-title":"Benchmark and integration of resources for the estimation of human transcription factor activities","volume":"29","author":"Garcia-Alonso","year":"2019","journal-title":"Genome Res."},{"issue":"D1","key":"10.1016\/j.tranon.2026.102750_bib0028","doi-asserted-by":"crossref","first-page":"D380","DOI":"10.1093\/nar\/gkx1013","article-title":"Trrust V2: an expanded reference database of human and mouse transcriptional regulatory interactions","volume":"46","author":"Han","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.tranon.2026.102750_bib0029","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using Cellchat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"issue":"46","key":"10.1016\/j.tranon.2026.102750_bib0030","doi-asserted-by":"crossref","first-page":"5975","DOI":"10.1038\/onc.2008.213","article-title":"Critical pathways in cellular senescence and immortalization revealed by gene expression profiling","volume":"27","author":"Fridman","year":"2008","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.tranon.2026.102750_bib0031","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13059-020-01990-9","article-title":"A multidimensional systems biology analysis of cellular senescence in aging and disease","volume":"21","author":"Avelar","year":"2020","journal-title":"Genome Biol."},{"issue":"Database issue","key":"10.1016\/j.tranon.2026.102750_bib0032","doi-asserted-by":"crossref","first-page":"D537","DOI":"10.1093\/nar\/gki017","article-title":"The human ageing genomic resources","volume":"33","author":"de Magalh\u00e3es","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.tranon.2026.102750_bib0033","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1101\/gr.277491.122","article-title":"A transcriptome-based single-cell biological age model and resource for tissue-specific aging measures","volume":"33","author":"Mao","year":"2023","journal-title":"Genome Res."},{"key":"10.1016\/j.tranon.2026.102750_bib0034","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1038\/ncomms3612","article-title":"Inferring tumour purity and stromal and immune cell admixture from expression data","volume":"4","author":"Yoshihara","year":"2013","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.tranon.2026.102750_bib0035","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","article-title":"A framework for advancing our understanding of cancer-associated fibroblasts","volume":"20","author":"Sahai","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.tranon.2026.102750_bib0036","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008721","article-title":"Postn(+) cancer-associated fibroblasts determine the efficacy of immunotherapy in hepatocellular carcinoma","volume":"12","author":"Wang","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"2","key":"10.1016\/j.tranon.2026.102750_bib0037","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.trecan.2024.11.005","article-title":"Functional heterogeneity of fibroblasts in primary tumors and metastases","volume":"11","author":"Cheng","year":"2025","journal-title":"Trends Cancer"},{"issue":"1","key":"10.1016\/j.tranon.2026.102750_bib0038","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-019-0638-6","article-title":"Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of rna-seq data","volume":"11","author":"Finotello","year":"2019","journal-title":"Genome Med."},{"issue":"9","key":"10.1016\/j.tranon.2026.102750_bib0039","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41568-025-00832-9","article-title":"Regulatory T cells in the tumour microenvironment","volume":"25","author":"Imianowski","year":"2025","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.tranon.2026.102750_bib0040","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.trecan.2023.11.007","article-title":"Metabolic interplay: tumor macrophages and regulatory T cells","volume":"10","author":"Vilbois","year":"2024","journal-title":"Trends Cancer"},{"issue":"11","key":"10.1016\/j.tranon.2026.102750_bib0041","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/cac2.12345","article-title":"Tumor-associated macrophages in liver cancer: from mechanisms to therapy","volume":"42","author":"Cheng","year":"2022","journal-title":"Cancer Commun. (Lond.)"},{"issue":"114","key":"10.1016\/j.tranon.2026.102750_bib0042","doi-asserted-by":"crossref","first-page":"eadz2273","DOI":"10.1126\/sciimmunol.adz2273","article-title":"Hypoxia-induced Egr1 remodels neutrophils to suppress antitumor immunity","volume":"10","author":"Chang","year":"2025","journal-title":"Sci. Immunol."},{"issue":"1","key":"10.1016\/j.tranon.2026.102750_bib0043","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1002\/imt2.11","article-title":"An attention mechanism-based deep neural network for protein lysine lactylation site prediction","volume":"1","author":"Lv","year":"2022","journal-title":"Imeta"},{"issue":"9","key":"10.1016\/j.tranon.2026.102750_bib0044","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41422-023-00844-w","article-title":"\u0391-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure","volume":"33","author":"Zhang","year":"2023","journal-title":"Cell. Res."},{"issue":"11","key":"10.1016\/j.tranon.2026.102750_bib0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00262-024-03796-1","article-title":"Efficacy of durvalumab plus chemotherapy in advanced biliary duct cancer and biomarkers exploration","volume":"73","author":"Lu","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.tranon.2026.102750_bib0046","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.semcancer.2024.05.002","article-title":"Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy","volume":"101","author":"Jiang","year":"2024","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.tranon.2026.102750_bib0047","article-title":"Integrated analysis of single-cell and bulk rna sequencing data reveals a cellular senescence-related signature in hepatocellular carcinoma","volume":"12","author":"Qiao","year":"2024","journal-title":"Front. Cell. Dev. Biol."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326000872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326000872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:09:58Z","timestamp":1776510598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523326000872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":47,"alternative-id":["S1936523326000872"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2026.102750","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EGR1 lactylation induces tumor cell senescence and immunosuppressive microenvironment in intrahepatic cholangiocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2026.102750","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102750"}}