{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:19:42Z","timestamp":1791613182400,"version":"4.3.4"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NIH R35 NS105076"],"award-info":[{"award-number":["NIH R35 NS105076"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Medicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.xcrm.2026.103090","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:06:08Z","timestamp":1791299168000},"page":"103090","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disruption of the Nav1.8\/Ankyrin-3 interaction in nociceptors reduces pathological pain-like behaviors in mice"],"prefix":"10.1016","author":[{"given":"Rasheen","family":"Powell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangsunze","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Lenfers","family":"Turnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veselina","family":"Petrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selwyn S.","family":"Jayakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keunjung","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Cropper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Arab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Kimourtzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Oses-Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma L.","family":"Burlingame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Waxman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulayman D.","family":"Dib-Hajj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-3897","authenticated-orcid":false,"given":"Clifford J.","family":"Woolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xcrm.2026.103090_bib1","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1172\/JCI45178","article-title":"What is this thing called pain?","volume":"120","author":"Woolf","year":"2010","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.xcrm.2026.103090_bib2","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(99)01311-2","article-title":"Pain: an overview","volume":"353","author":"Loeser","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.xcrm.2026.103090_bib3","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/S0140-6736(99)04088-X","article-title":"Management of chronic pain","volume":"353","author":"Ashburn","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.xcrm.2026.103090_bib4","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrn3516","article-title":"Cognitive and emotional control of pain and its disruption in chronic pain","volume":"14","author":"Bushnell","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.xcrm.2026.103090_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2006.09.021","article-title":"Mechanisms of Neuropathic Pain","volume":"52","author":"Campbell","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2026.103090_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic Pain: From Mechanisms to Treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.xcrm.2026.103090_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.pain.2011.10.028","article-title":"Prevalence and aetiology of neuropathic pain in cancer patients: A systematic review","volume":"153","author":"Bennett","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.xcrm.2026.103090_bib8","doi-asserted-by":"crossref","first-page":"e869","DOI":"10.1097\/PR9.0000000000000869","article-title":"Angiotensin receptors and neuropathic pain","volume":"6","author":"Balogh","year":"2021","journal-title":"Pain Rep."},{"key":"10.1016\/j.xcrm.2026.103090_bib9","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1002\/hbm.25401","article-title":"Supraspinal nociceptive networks in neuropathic pain after spinal cord injury","volume":"42","author":"Huynh","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.xcrm.2026.103090_bib10","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41586-024-08535-1","article-title":"Macrophages protect against sensory axon loss in peripheral neuropathy","volume":"640","author":"Hakim","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.xcrm.2026.103090_bib11","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/s41590-024-01857-2","article-title":"Nociceptor-immune interactomes reveal insult-specific immune signatures of pain","volume":"25","author":"Jain","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.xcrm.2026.103090_bib12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41582-025-01127-1","article-title":"Targeting sodium channels \u2014 challenges for acute pain and the leap to chronic pain","volume":"21","author":"Alsaloum","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.xcrm.2026.103090_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/JCI191346","article-title":"Mechanism-based nonopioid analgesic targets","volume":"135","author":"Zeng","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.xcrm.2026.103090_bib14","doi-asserted-by":"crossref","DOI":"10.1177\/2058738419838383","article-title":"The neuropathic pain: An overview of the current treatment and future therapeutic approaches","volume":"33","author":"Cavalli","year":"2019","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.xcrm.2026.103090_bib15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s40122-024-00697-0","article-title":"Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective NaV1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain","volume":"14","author":"Osteen","year":"2025","journal-title":"Pain Ther."},{"key":"10.1016\/j.xcrm.2026.103090_bib16","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.3390\/ijerph19074071","article-title":"Virtual Reality Assisted Non-Pharmacological Treatments in Chronic Pain Management: A Systematic Review and Quantitative Meta-Analysis","volume":"19","author":"Grassini","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.xcrm.2026.103090_bib17","doi-asserted-by":"crossref","first-page":"105568","DOI":"10.1016\/j.biocel.2019.105568","article-title":"Virtual Reality interventions for acute and chronic pain management","volume":"114","author":"Ahmadpour","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.xcrm.2026.103090_bib18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1474-4422(25)00068-7","article-title":"Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis","volume":"24","author":"Soliman","year":"2025","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.xcrm.2026.103090_bib19","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1517\/14728222.2016.1162295","article-title":"Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief","volume":"20","author":"Emery","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.xcrm.2026.103090_bib20","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1152\/physrev.00052.2017","article-title":"The Role of Voltage-Gated Sodium Channels in Pain Signaling","volume":"99","author":"Bennett","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.xcrm.2026.103090_bib21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41583-021-00444-w","article-title":"The physiological function of different voltage-gated sodium channels in pain","volume":"22","author":"Goodwin","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.xcrm.2026.103090_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1744-8069-9-52","article-title":"Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas","volume":"9","author":"Bird","year":"2013","journal-title":"Mol. Pain"},{"key":"10.1016\/j.xcrm.2026.103090_bib23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1600-0854.2009.01027.x","article-title":"Prostaglandin E2 Promotes Nav1.8 Trafficking via Its Intracellular RRR Motif Through the Protein Kinase A Pathway","volume":"11","author":"Liu","year":"2010","journal-title":"Traffic"},{"key":"10.1016\/j.xcrm.2026.103090_bib24","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1096\/fj.201802454RR","article-title":"Magi-1 scaffolds NaV1.8 and Slack KNa channels in dorsal root ganglion neurons regulating excitability and pain","volume":"33","author":"Pryce","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.xcrm.2026.103090_bib25","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1073\/pnas.0611364104","article-title":"A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat","volume":"104","author":"Jarvis","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2026.103090_bib26","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1097\/j.pain.0000000000003470","article-title":"Pharmacologically enabling the degradation of NaV1.8 channels to reduce neuropathic pain","volume":"166","author":"Martin","year":"2025","journal-title":"Pain"},{"key":"10.1016\/j.xcrm.2026.103090_bib27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/jn.2001.86.2.629","article-title":"Contribution of Nav1.8 Sodium Channels to Action Potential Electrogenesis in DRG Neurons","volume":"86","author":"Renganathan","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.xcrm.2026.103090_bib28","doi-asserted-by":"crossref","first-page":"10277","DOI":"10.1523\/JNEUROSCI.22-23-10277.2002","article-title":"Roles of Tetrodotoxin (TTX)-Sensitive Na+ Current, TTX-Resistant Na+ Current, and Ca2+ Current in the Action Potentials of Nociceptive Sensory Neurons","volume":"22","author":"Blair","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.xcrm.2026.103090_bib29","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202413596","article-title":"Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain","volume":"156","author":"Vasylyev","year":"2024","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.xcrm.2026.103090_bib30","doi-asserted-by":"crossref","first-page":"750583","DOI":"10.3389\/fpain.2021.750583","article-title":"Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets","volume":"2","author":"Alles","year":"2021","journal-title":"Front. Pain Res."},{"key":"10.1016\/j.xcrm.2026.103090_bib31","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa2209870","article-title":"Selective Inhibition of NaV1.8 with VX-548 for Acute Pain","volume":"389","author":"Jones","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.xcrm.2026.103090_bib32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1056\/NEJMe2305708","article-title":"Targeting a Peripheral Sodium Channel to Treat Pain","volume":"389","author":"Waxman","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.xcrm.2026.103090_bib33","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1152\/jn.01264.2005","article-title":"Ankyrin-G Regulates Inactivation Gating of the Neuronal Sodium Channel, Nav1.6","volume":"96","author":"Shirahata","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.xcrm.2026.103090_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.devcel.2013.11.023","article-title":"Ankyrin-G Directly Binds to Kinesin-1 to Transport Voltage-Gated Na+ Channels into Axons","volume":"28","author":"Barry","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.xcrm.2026.103090_bib35","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2215417120","article-title":"Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity","volume":"120","author":"Higerd-Rusli","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2026.103090_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-02262-0","article-title":"Voltage-gated sodium channels assemble and gate as dimers","volume":"8","author":"Clatot","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103090_bib37","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1152\/jn.00676.2003","article-title":"Modulation of Nav1.7 and Nav1.8 Peripheral Nerve Sodium Channels by Protein Kinase A and Protein Kinase C","volume":"91","author":"Vijayaragavan","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.xcrm.2026.103090_bib38","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1242\/jcs.026856","article-title":"The voltage-gated Na+ channel Nav1.8 contains an ER-retention\/retrieval signal antagonized by the beta3 subunit","volume":"121","author":"Zhang","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.xcrm.2026.103090_bib39","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003012","article-title":"Membrane Domains Based on Ankyrin and Spectrin Associated with Cell\u2013Cell Interactions","volume":"1","author":"Bennett","year":"2009","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.xcrm.2026.103090_bib40","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1074\/jbc.M607096200","article-title":"Targeting and Stability of Na\/Ca Exchanger 1 in Cardiomyocytes Requires Direct Interaction with the Membrane Adaptor Ankyrin-B\u2217","volume":"282","author":"Cunha","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.xcrm.2026.103090_bib41","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00429-012-0443-0","article-title":"Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons","volume":"218","author":"Engelhardt","year":"2013","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.xcrm.2026.103090_bib42","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52373","article-title":"Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc","volume":"9","author":"Yang","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.xcrm.2026.103090_bib43","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1083\/jcb.200710107","article-title":"Voltage-gated Nav channel targeting in the heart requires an ankyrin-G\u2013dependent cellular pathway","volume":"180","author":"Lowe","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.xcrm.2026.103090_bib44","doi-asserted-by":"crossref","first-page":"19717","DOI":"10.1073\/pnas.1909989116","article-title":"Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly","volume":"116","author":"Yang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2026.103090_bib45","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1073\/pnas.1417989112","article-title":"Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors","volume":"112","author":"Tseng","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2026.103090_bib46","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201910053","article-title":"Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules","volume":"219","author":"Chen","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.xcrm.2026.103090_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.69815","article-title":"Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A","volume":"10","author":"Creighton","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.xcrm.2026.103090_bib48","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuron.2008.02.017","article-title":"A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion","volume":"58","author":"Pielage","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2026.103090_bib49","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bpj.2016.11.880","article-title":"An Ancient Role for Giant Ankyrins in Axon Initial Segment Organization","volume":"112","author":"Jegla","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.xcrm.2026.103090_bib50","doi-asserted-by":"crossref","first-page":"7232","DOI":"10.1523\/JNEUROSCI.5434-11.2012","article-title":"An AnkyrinG-Binding Motif Is Necessary and Sufficient for Targeting Nav1.6 Sodium Channels to Axon Initial Segments and Nodes of Ranvier","volume":"32","author":"Gasser","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.xcrm.2026.103090_bib51","doi-asserted-by":"crossref","first-page":"17533","DOI":"10.1073\/pnas.0403711101","article-title":"Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes","volume":"101","author":"Mohler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xcrm.2026.103090_bib52","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1038\/s41380-018-0308-x","article-title":"Ankyrin-G Regulates Forebrain Connectivity and Network Synchronization via Interaction with GABARAP","volume":"25","author":"Nelson","year":"2020","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.xcrm.2026.103090_bib53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/jnc.12785","article-title":"Tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 constitutively interacts with ankyrin G","volume":"131","author":"Montersino","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.xcrm.2026.103090_bib54","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj9173","article-title":"Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia","volume":"10","author":"Bhuiyan","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.xcrm.2026.103090_bib55","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj8186","article-title":"Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors","volume":"14","author":"Tavares-Ferreira","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.xcrm.2026.103090_bib56","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1038\/s41467-021-26100-6","article-title":"Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior","volume":"12","author":"Powell","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103090_bib57","doi-asserted-by":"crossref","first-page":"19304","DOI":"10.1074\/jbc.M117.804716","article-title":"Protein kinase A\u2013induced internalization of Slack channels from the neuronal membrane occurs by adaptor protein-2\/clathrin\u2013mediated endocytosis","volume":"292","author":"Gururaj","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.xcrm.2026.103090_bib58","doi-asserted-by":"crossref","first-page":"10345","DOI":"10.1523\/JNEUROSCI.18-24-10345.1998","article-title":"Modulation of TTX-R INa by PKC and PKA and Their Role in PGE2-Induced Sensitization of Rat Sensory Neurons In","volume":"18","author":"Gold","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.xcrm.2026.103090_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.959660","article-title":"Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage-gated sodium channel NaV1.2 in neurons","volume":"14","author":"Gupta","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.xcrm.2026.103090_bib60","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/nn.3859","article-title":"A HIERARCHY OF ANKYRIN\/SPECTRIN COMPLEXES CLUSTERS SODIUM CHANNELS AT NODES OF RANVIER","volume":"17","author":"Ho","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.xcrm.2026.103090_bib61","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1083\/jcb.114.6.1243","article-title":"Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice","volume":"114","author":"Kordeli","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.xcrm.2026.103090_bib62","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.neuron.2014.12.065","article-title":"Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain","volume":"85","author":"Weng","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2026.103090_bib63","article-title":"Identifying the function of the NMDA NR1 C2 subunit through its interaction with Magi-2 during inflammatory pain","author":"Sheehan","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.xcrm.2026.103090_bib64","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.04353","article-title":"Structural basis of diverse membrane target recognitions by ankyrins","volume":"3","author":"Wang","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.xcrm.2026.103090_bib65","unstructured":"Neurosnap | Online Bioinformatics Tools \u2013 Fast, Easy, Code-Free. https:\/\/neurosnap.ai\/."},{"key":"10.1016\/j.xcrm.2026.103090_bib66","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29150","article-title":"Autoinhibition of ankyrin-B\/G membrane target bindings by intrinsically disordered segments from the tail regions","volume":"6","author":"Chen","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.xcrm.2026.103090_bib67","article-title":"A genetically defined injured C-fibre nociceptor associated with neuromas drives chronic spontaneous neuropathic pain","author":"Zeng","year":"2026","journal-title":"bioRxiv"},{"key":"10.1016\/j.xcrm.2026.103090_bib68","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/2049463720912496","article-title":"Gabapentinoids: pharmacokinetics, pharmacodynamics and considerations for clinical practice","volume":"14","author":"Chincholkar","year":"2020","journal-title":"Br. J. Pain"},{"key":"10.1016\/j.xcrm.2026.103090_bib69","article-title":"Gabapentin for chronic neuropathic pain and fibromyalgia in adults","volume":"2014","author":"Moore","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.xcrm.2026.103090_bib70","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1046\/j.0003-2409.2001.02399.x","article-title":"Gabapentin: pharmacology and its use in pain management","volume":"57","author":"Rose","year":"2002","journal-title":"Anaesthesia"},{"key":"10.1016\/j.xcrm.2026.103090_bib71","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.200612012","article-title":"Nodes of Ranvier and axon initial segments are ankyrin G\u2013dependent domains that assemble by distinct mechanisms","volume":"177","author":"Dzhashiashvili","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.xcrm.2026.103090_bib72","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbrc.2021.09.017","article-title":"The largest isoform of Ankyrin-G is required for lattice structure of the axon initial segment","volume":"578","author":"Wang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.xcrm.2026.103090_bib73","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.neuron.2019.03.005","article-title":"Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In","volume":"102","author":"Goldstein","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.xcrm.2026.103090_bib74","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0169-328X(96)00241-0","article-title":"Sodium channel \u03b1-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system","volume":"45","author":"Felts","year":"1997","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.xcrm.2026.103090_bib75","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1152\/jn.1994.72.1.466","article-title":"Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy","volume":"72","author":"Waxman","year":"1994","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.xcrm.2026.103090_bib76","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1523\/JNEUROSCI.0058-22.2022","article-title":"Depolarizing NaV and Hyperpolarizing KV Channels Are Co-Trafficked in Sensory Neurons","volume":"42","author":"Higerd-Rusli","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.xcrm.2026.103090_bib77","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.mcn.2004.11.007","article-title":"CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Nav1.8","volume":"28","author":"Liu","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.xcrm.2026.103090_bib78","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1172\/JCI68996","article-title":"Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain","volume":"123","author":"Laedermann","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.xcrm.2026.103090_bib79","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1152\/jn.00854.2005","article-title":"Calmodulin Regulates Current Density and Frequency-Dependent Inhibition of Sodium Channel Nav1.8 in DRG Neurons","volume":"96","author":"Choi","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.xcrm.2026.103090_bib80","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1083\/jcb.200204010","article-title":"Selective internalization of sodium channels in rat dorsal root ganglion neurons infected with herpes simplex virus-1","volume":"158","author":"Storey","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.xcrm.2026.103090_bib81","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1083\/jcb.200805169","article-title":"Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G","volume":"183","author":"Br\u00e9chet","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.xcrm.2026.103090_bib82","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1074\/jbc.M115.648386","article-title":"Ankyrin-G Inhibits Endocytosis of Cadherin Dimers","volume":"291","author":"Cadwell","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.xcrm.2026.103090_bib83","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500301","article-title":"Dynamic spectrin\/ankyrin-G microdomains promote lateral membrane assembly by opposing endocytosis","volume":"1","author":"Jenkins","year":"2015","journal-title":"Sci. Adv."},{"key":"10.1016\/j.xcrm.2026.103090_bib84","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/ana.21527","article-title":"Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas","volume":"64","author":"Black","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.xcrm.2026.103090_bib85","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jocn.2003.09.023","article-title":"Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain","volume":"11","author":"Kretschmer","year":"2004","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.xcrm.2026.103090_bib86","doi-asserted-by":"crossref","first-page":"7740","DOI":"10.1523\/JNEUROSCI.6136-09.2010","article-title":"Isolation of Somatic Na+ Currents by Selective Inactivation of Axonal Channels with a Voltage Prepulse","volume":"30","author":"Milescu","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.xcrm.2026.103090_bib87","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkae1011","article-title":"The PRIDE database at 20 years: 2025 update","volume":"53","author":"Perez-Riverol","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xcrm.2026.103090_bib88","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.xcrm.2026.103090_bib89","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142687","article-title":"Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney","volume":"11","author":"Stankewich","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.xcrm.2026.103090_bib90","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41590-019-0559-y","article-title":"T cells instruct myeloid cells to produce inflammasome-independent IL-1\u03b2 and cause autoimmunity","volume":"21","author":"Jain","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.xcrm.2026.103090_bib91","doi-asserted-by":"crossref","first-page":"17360","DOI":"10.1038\/s41598-024-67793-1","article-title":"Prostaglandin E2 depolarises sensory axons in vitro in an ANO1 and Nav1.8 dependent manner","volume":"14","author":"Kimourtzis","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xcrm.2026.103090_bib92","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1038\/s41467-025-58303-6","article-title":"Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration","volume":"16","author":"Heo","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xcrm.2026.103090_bib93","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00433","article-title":"Up\u2013Down Reader: An Open Source Program for Efficiently Processing 50% von Frey Thresholds","volume":"9","author":"Gonzalez-Cano","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.xcrm.2026.103090_bib94","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1097\/j.pain.0000000000002680","article-title":"Automated preclinical detection of mechanical pain hypersensitivity and analgesia","volume":"163","author":"Zhang","year":"2022","journal-title":"Pain"},{"key":"10.1016\/j.xcrm.2026.103090_bib95","doi-asserted-by":"crossref","first-page":"116494","DOI":"10.1016\/j.celrep.2025.116494","article-title":"Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS\/FTD-associated autophagy networks","volume":"44","author":"Smeyers","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.xcrm.2026.103090_bib96","doi-asserted-by":"crossref","first-page":"M111","DOI":"10.1074\/mcp.M111.010728","article-title":"Data Processing Pipeline for Mammalian Proteome Dynamics Studies Using Stable Isotope Metabolic Labeling","volume":"10","author":"Guan","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.xcrm.2026.103090_bib97","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1021\/ac9810516","article-title":"Role of accurate mass measurement (+\/- 10 ppm) in protein identification strategies employing MS or MS\/MS and database searching","volume":"71","author":"Clauser","year":"1999","journal-title":"Anal. Chem."}],"container-title":["Cell Reports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379126005070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666379126005070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:07:10Z","timestamp":1791410830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666379126005070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":97,"alternative-id":["S2666379126005070"],"URL":"https:\/\/doi.org\/10.1016\/j.xcrm.2026.103090","relation":{},"ISSN":["2666-3791"],"issn-type":[{"value":"2666-3791","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of the Nav1.8\/Ankyrin-3 interaction in nociceptors reduces pathological pain-like behaviors in mice","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2026.103090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103090"}}