{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:05:16Z","timestamp":1776182716972,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-10-IDEX-0002-02"],"award-info":[{"award-number":["ANR-10-IDEX-0002-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-10-INBS-05"],"award-info":[{"award-number":["ANR-10-INBS-05"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-10-LABX-0030-INRT"],"award-info":[{"award-number":["ANR-10-LABX-0030-INRT"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["G0D0120N"],"award-info":[{"award-number":["G0D0120N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["G081723N"],"award-info":[{"award-number":["G081723N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011929","name":"Programa Operacional Tem\u00e1tico Factores de Competitividade","doi-asserted-by":"publisher","award":["2021.05421"],"award-info":[{"award-number":["2021.05421"]}],"id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011658","name":"French Infrastructure for Integrated Structural Biology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED431C-2017\/70"],"award-info":[{"award-number":["ED431C-2017\/70"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED481A-2021\/273"],"award-info":[{"award-number":["ED481A-2021\/273"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006761","name":"Universidade de Vigo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.yexmp.2026.105036","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:55:40Z","timestamp":1771880140000},"page":"105036","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["25-nitro-20-epi-vitamin D analogue with anti-proliferative and cytoprotective properties: Biological and pharmacological evaluation"],"prefix":"10.1016","volume":"145","author":[{"given":"Ux\u00eda","family":"G\u00f3mez-Bouz\u00f3","sequence":"first","affiliation":[]},{"given":"Carole","family":"Peluso-Iltis","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Barreiro","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"Lieve","family":"Verlinden","sequence":"additional","affiliation":[]},{"given":"Annemieke","family":"Verstuyf","sequence":"additional","affiliation":[]},{"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[]},{"given":"Natacha","family":"Rochel","sequence":"additional","affiliation":[]},{"given":"Generosa","family":"G\u00f3mez","sequence":"additional","affiliation":[]},{"given":"Yagamare","family":"Fall","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2026.105036_bb0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.yexmp.2026.105036_bb0010","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/0006-2952(91)90426-6","article-title":"20-EPI-vitamin D3 analogues: a novel class of potent regulators of cell growth and immune responses","volume":"42","author":"Binderup","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105036_bb0015","article-title":"Protective effects of novel derivatives of vitamin D\u2083 and lumisterol against UVB-induced damage in human keratinocytes involve activation of the Nrf2 and p53 defense mechanisms","volume":"26","author":"Chaiprasongsuk","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.yexmp.2026.105036_bb0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jsbmb.2006.12.003","article-title":"Adaptability of the vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation","volume":"103","author":"Ciesielski","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.yexmp.2026.105036_bb0025","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0006-2952(94)90409-X","article-title":"Increased biological activity of 20-EPI-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding","volume":"47","author":"Dilworth","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105036_bib141","doi-asserted-by":"crossref","first-page":"e908","DOI":"10.21769\/BioProtoc.908","article-title":"Isolation of mouse embryo fibroblasts","volume":"3","author":"Durkin","year":"2013","journal-title":"Bio Protoc"},{"key":"10.1016\/j.yexmp.2026.105036_bb0030","first-page":"2717","article-title":"Vitamin D analogs and coactivators","volume":"26","author":"Eelen","year":"2006","journal-title":"Anticancer Res."},{"key":"10.1016\/j.yexmp.2026.105036_bb0035","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.yexmp.2026.105036_bb0040","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1107\/S0907444905036693","article-title":"Scaling and assessment of data quality","volume":"62","author":"Evans","year":"2006","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.yexmp.2026.105036_bb0045","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1021\/acs.bioconjchem.8b00383","article-title":"Desrisking the cytotoxicity of a mitochondriotropic antioxidant based on caffeic acid by a PEGylated strategy","volume":"29","author":"Fernandes","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.yexmp.2026.105036_bb0050","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1021\/acs.bioconjchem.8b00151","article-title":"Development of a PEGylated-based platform for efficient delivery of dietary antioxidants across the blood\u2013brain barrier","volume":"29","author":"Fernandes","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.yexmp.2026.105036_bb0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jsbmb.2018.08.006","article-title":"Synthesis of a novel analog of calcitriol and its biological evaluation as antitumor agent","volume":"185","author":"Ferronato","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.yexmp.2026.105036_bb0060","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0960-894X(98)00363-1","volume":"8","author":"Fujishima","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.yexmp.2026.105036_bb0065","doi-asserted-by":"crossref","first-page":"106528","DOI":"10.1016\/j.bioorg.2023.106528","article-title":"Structural analysis and biological activities of C25-amino and C25-nitro vitamin D analogs","volume":"136","author":"G\u00f3mez-Bouz\u00f3","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.yexmp.2026.105036_bb0070","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"Software XDS for image rotation, recognition and crystal symmetry assignment","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.yexmp.2026.105036_bib142","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1073\/pnas.94.18.9831","article-title":"Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia","volume":"94","author":"Li","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2026.105036_bb0075","doi-asserted-by":"crossref","first-page":"103518","DOI":"10.1016\/j.redox.2025.103518","article-title":"Protective role of vitamin D receptor against mitochondrial calcium overload from PM(2.5)-induced injury in renal tubular cells","volume":"80","author":"Lu","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.yexmp.2026.105036_bb0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/cells13010011","article-title":"VDR and PDIA3 are essential for activation of calcium signaling and membrane response to 1,25(OH)(2)D(3) in squamous cell carcinoma cells","volume":"13","author":"Nowak","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.yexmp.2026.105036_bb0085","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3390\/biomedicines13041002","article-title":"Recent advancements towards the use of vitamin D isoforms and the development of their synthetic analogues as new therapeutics","volume":"13","author":"Patel","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.yexmp.2026.105036_bb0090","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1021\/acsptsci.4c00124","article-title":"Cellular and mitochondrial toxicity of tolcapone, entacapone, and new nitrocatechol derivatives","volume":"7","author":"Pinto","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.yexmp.2026.105036_bb0095","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1002\/ejoc.200300264","article-title":"Organic chemistry of vitamin D analogues (deltanoids)","volume":"2003","author":"Posner","year":"2003","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.yexmp.2026.105036_bb0100","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1016\/j.tetlet.2013.04.019","article-title":"Pd-allylic substitution mediated synthesis of 25-amino vitamin D3 derivatives","volume":"54","author":"Rivadulla","year":"2013","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.yexmp.2026.105036_bb0105","series-title":"Vitamin D","article-title":"Structural basis for ligand activity in VDR","author":"Rochel","year":"2011"},{"key":"10.1016\/j.yexmp.2026.105036_bb0110","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1097-2765(00)80413-X","article-title":"The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand","volume":"5","author":"Rochel","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.yexmp.2026.105036_bb0115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12013-020-00913-6","article-title":"Photoprotective properties of vitamin D and Lumisterol Hydroxyderivatives","volume":"78","author":"Slominski","year":"2020","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.yexmp.2026.105036_bb0120","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2022.5386","article-title":"CYP11A1-derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas","volume":"61","author":"Slominski","year":"2022","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.yexmp.2026.105036_bb0125","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/j.jid.2024.04.022","article-title":"Biological effects of CYP11A1-derived vitamin D and Lumisterol metabolites in the skin","volume":"144","author":"Slominski","year":"2024","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.yexmp.2026.105036_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16122262","article-title":"Malignant melanoma: an overview, new perspectives, and vitamin D signaling","volume":"16","author":"Slominski","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.yexmp.2026.105036_bb0135","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1107\/S0907444911056058","article-title":"Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER","volume":"68","author":"Smart","year":"2012","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.yexmp.2026.105036_bb0140","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3390\/genes14091691","article-title":"Vitamin D: an overview of gene regulation, ranging from metabolism to genomic effects","volume":"14","author":"Voltan","year":"2023","journal-title":"Genes"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T15:09:41Z","timestamp":1776179381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480026000158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":30,"alternative-id":["S0014480026000158"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105036","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"25-nitro-20-epi-vitamin D analogue with anti-proliferative and cytoprotective properties: Biological and pharmacological evaluation","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105036"}}