{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T14:28:04Z","timestamp":1777127284191,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[1999,5]]},"DOI":"10.1016\/s0006-8993(99)01387-6","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T21:55:17Z","timestamp":1027634117000},"page":"143-150","source":"Crossref","is-referenced-by-count":77,"title":["l-DOPA transport properties in an immortalised cell line of rat capillary cerebral endothelial cells, RBE 4"],"prefix":"10.1016","volume":"829","author":[{"given":"Pedro","family":"Gomes","sequence":"first","affiliation":[]},{"given":"P","family":"Soares-da-Silva","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0006-8993(99)01387-6_BIB1","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1212\/WNL.44.8.1491","article-title":"Effect of plasma levels of large neutral amino acids and degree of parkinsonism on the blood-to-brain transport of l-DOPA in naive and MPTP Parkinsonian monkeys","volume":"44","author":"Alexander","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/S0006-8993(99)01387-6_BIB2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1471-4159.1986.tb04527.x","article-title":"Characteristics of the large neutral amino acid transport system of bovine brain microvessel endothelial cell monolayers","volume":"47","author":"Audus","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB3","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1046\/j.1471-4159.1996.67030988.x","article-title":"Functional expression of P-glycoprotein in an immortalised cell line of rat brain endothelial cells, RBE 4","volume":"67","author":"Begley","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB5","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/0006-2952(75)90050-7","article-title":"Tight binding inhibitors: I. Kinetic behavior","volume":"24","author":"Cha","year":"1975","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB6","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","article-title":"Relationship between the inhibition constant (Ki) and the concentration of the inhibitor which causes 50% inhibition (IC50) of an enzymatic reaction","volume":"22","author":"Cheng","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3940(97)00679-4","article-title":"Modulation of P-glycoprotein activity by glial factors and retinoic acid in an immortalized rat brain microvessel endothelial cell line","volume":"236","author":"El Hafny","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB8","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1152\/physrev.1983.63.2.484","article-title":"Role of precursor availability in control of monoamine biosynthesis in brain","volume":"63","author":"Fernstrom","year":"1983","journal-title":"Physiol. Rev."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1136\/jnnp.52.9.1063","article-title":"The effects of oral protein on the absorption of intraduodenal l-DOPA and motor performance","volume":"52","author":"Frankel","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/S0006-8993(99)01387-6_BIB10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0014-2999(97)01083-2","article-title":"Competitive and non-competitive inhibition of l-3,4-dihydroxyphenylalanine uptake in Opossum kidney cells","volume":"332","author":"Gomes","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB11","unstructured":"H.J. Motulsky, P. Spannard, R. Neubig, GraphPad Prism (version 1.0), GraphPad Prism Software, San Diego, USA, 1994."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0014-2999(96)00643-7","article-title":"Ethanol potentiates lipopolysaccharide- or interleukin-1 \u03b2-induced nitric oxide generation in RBE 4 cells","volume":"313","author":"Naassila","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-2999(98)00671-2","article-title":"Modulation of the effects of extracellular ATP on [Ca2+]i in rat brain microvascular endothelial cells","volume":"361","author":"Nobles","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/jnnp.52.4.481","article-title":"Influence of fluctuations of plasma large neutral amino acids with normal diets on the clinical response to l-DOPA","volume":"52","author":"Nutt","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/S0006-8993(99)01387-6_BIB15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0169-409X(95)00003-P","article-title":"Transport of small molecules through the blood\u2013brain barrier: biology and methodology","volume":"15","author":"Pardridge","year":"1995","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1471-4159.1977.tb07702.x","article-title":"Transport of metabolic substrates through the blood\u2013brain barrier","volume":"28","author":"Pardridge","year":"1977","journal-title":"J. Neurochem."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB17","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1476-5381.1996.tb15462.x","article-title":"Studies on the pharmacology of the inward transport of l-DOPA in rat renal tubules","volume":"118","author":"Pinto-do-\u00d3","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-4165(96)00131-6","article-title":"Glucose transport in immortalized rat brain capillary endothelial cells in vitro: transport activity and GLUT1 expression","volume":"1335","author":"Regina","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0006-8993(99)01387-6_BIB19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/jcp.1041590114","article-title":"Regulation of \u03b3-glutamyl-transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells","volume":"159","author":"Roux","year":"1994","journal-title":"J. Cell Physiol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB20","doi-asserted-by":"crossref","first-page":"25951","DOI":"10.1016\/S0021-9258(18)35701-6","article-title":"Neutral amino acid transport by the blood\u2013brain barrier. Membrane vesicle studies","volume":"267","author":"Sanchez del Pino","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB21","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1476-5381.1994.tb13118.x","article-title":"Cell inward transport of l-DOPA and 3-O-methyl-l-DOPA in rat renal tubules","volume":"112","author":"Soares-da-Silva","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB22","first-page":"F243","article-title":"Apical and basolateral uptake and intracellular fate of dopamine precursor l-DOPA in LLC-PK1 cells","volume":"274","author":"Soares-da-Silva","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB23","first-page":"F632","article-title":"Apical and basal uptake of l-DOPA and l-5-HTP and their corresponding amines, dopamine and 5-HT, in OK cells","volume":"272","author":"Vieira-Coelho","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB24","doi-asserted-by":"crossref","first-page":"C104","DOI":"10.1152\/ajpcell.1998.275.1.C104","article-title":"Uptake and intracellular fate of l-3,4-dihydroxyphenylalanine, the dopamine precursor, in a human intestinal epithelial cells line: Caco-2","volume":"275","author":"Vieira-Coelho","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0024-3205(75)90248-9","article-title":"3-O-methyl-DOPA uptake and inhibition of l-DOPA at the blood\u2013brain barrier","volume":"17","author":"Wade","year":"1975","journal-title":"Life Sci."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1471-4159.1975.tb04415.x","article-title":"Synthetic amino acids and the nature of l-DOPA transport at the blood\u2013brain barrier","volume":"25","author":"Wade","year":"1975","journal-title":"J. Neurochem."},{"key":"10.1016\/S0006-8993(99)01387-6_BIB27","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1212\/WNL.43.9.1704","article-title":"The effect of l-DOPA infusions with and without phenylalanine challenges in parkinsonian patients: plasma and ventricular CSF l-DOPA levels and clinical responses","volume":"43","author":"Woodward","year":"1993","journal-title":"Neurology"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899399013876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899399013876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T06:38:52Z","timestamp":1620801532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899399013876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":27,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["S0006899399013876"],"URL":"https:\/\/doi.org\/10.1016\/s0006-8993(99)01387-6","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}