{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:45:33Z","timestamp":1761821133578},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1016\/s0014-2999(00)00659-2","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T14:34:24Z","timestamp":1027607664000},"page":"191-201","source":"Crossref","is-referenced-by-count":44,"title":["Neurotoxic\/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024"],"prefix":"10.1016","volume":"406","author":[{"given":"Ant\u00f3nio F","family":"Ambr\u00f3sio","sequence":"first","affiliation":[]},{"given":"Ana P","family":"Silva","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o O","family":"Malva","sequence":"additional","affiliation":[]},{"given":"Patr\u0131\u0301cio","family":"Soares-da-Silva","sequence":"additional","affiliation":[]},{"given":"Ars\u00e9lio P","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Caetana M","family":"Carvalho","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0014-2999(00)00659-2_BIB1","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1046\/j.1460-9568.2000.00091.x","article-title":"Role of desensitization of AMPA receptors on the neuronal viability and on the [Ca2+]i changes in cultured hippocampal neurons","volume":"12","author":"Ambr\u00f3sio","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB2","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S0028-3908(99)00058-1","article-title":"Carbamazepine inhibits L-type Ca2+ channels in cultured hippocampal neurons stimulated with glutamate receptor agonists","volume":"38","author":"Ambr\u00f3sio","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/S0014-2999(00)00659-2_BIB3","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1021\/jm980627g","article-title":"Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives","volume":"42","author":"Benes","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB4","unstructured":"Benes, J., Soares-Da-Silva, P., Learmonth, D.A., 1999b. Derivatives of 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide. US Patent. Patent Number 5,866,566."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/jnr.490350513","article-title":"Optimized survival of hippocampal neurons in B27-supplemented Neurobasal\u2122, a new serum-free medium combination","volume":"35","author":"Brewer","year":"1993","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-2999(97)83041-5","article-title":"Carbamazepine increases extracellular serotonin concentration: lack of antagonism by tetrodotoxin or zero Ca2+","volume":"328","author":"Dailey","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0924-977X(97)00406-9","article-title":"Side effects from increased doses of carbamazepine on neuropsychological and posturographic parameters of humans","volume":"7","author":"Delcker","year":"1997","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000026530","article-title":"New antiepileptic drugs in epileptology","volume":"38","author":"Elger","year":"1998","journal-title":"Neuropsychobiology"},{"key":"10.1016\/S0014-2999(00)00659-2_BIB9","first-page":"1549","article-title":"Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam","volume":"266","author":"Fern","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB10","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1038\/sj.bjp.0702472","article-title":"Effects of anti-epileptic drugs on glutamine synthetase activity in mouse brain","volume":"126","author":"Fraser","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0304-3940(92)90426-8","article-title":"Carbamazepine-induced neurotoxicity and its prevention by NMDA in cultured cerebellar granule cells","volume":"135","author":"Gao","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0006-8993(95)01066-1","article-title":"Carbamazepine induction of apoptosis in cultured cerebellar neurons: effects of N-methyl-d-aspartate, aurintricarboxylic acid and cycloheximide","volume":"703","author":"Gao","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB13","first-page":"1017","volume":"260","author":"Grant","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0920-1211(98)00084-9","article-title":"Congenital malformations due to antiepileptic drugs","volume":"33","author":"Kaneko","year":"1999","journal-title":"Epilepsy Res."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB15","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1124\/mol.51.6.1077","article-title":"Carbamazepine inhibition of neuronal Na+ currents \u2014 quantitative distinction from phenytoin and possible therapeutic implications","volume":"51","author":"Kuo","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB16","first-page":"89","article-title":"Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade","volume":"7","author":"Lakics","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/S0014-2999(00)00659-2_BIB17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3940(99)00810-1","article-title":"Effects of anticonvulsants on veratridine- and KCl-evoked glutamate release from rat cortical synaptosomes","volume":"276","author":"Lingamaneni","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB18","series-title":"Antiepileptic Drugs","first-page":"555","article-title":"Carbamazepine. Clinical use","author":"Loiseau","year":"1995"},{"key":"10.1016\/S0014-2999(00)00659-2_BIB19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(97)01514-8","article-title":"New visions in the pharmacology of anticonvulsion","volume":"342","author":"L\u00f6scher","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB20","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0301-0082(97)00092-0","article-title":"Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy","volume":"54","author":"L\u00f6scher","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0197-4580(94)00150-2","article-title":"Anticonvulsants attenuate amyloid \u03b2-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology","volume":"16","author":"Mark","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/S0014-2999(00)00659-2_BIB22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0006-8993(89)91514-X","article-title":"Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture","volume":"478","author":"Mattson","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/syn.890060210","article-title":"Pharmacology of N-methyl-d-aspartate-induced brain injury in an in vivo perinatal rat model","volume":"6","author":"McDonald","year":"1990","journal-title":"Synapse"},{"issue":"Suppl. 35","key":"10.1016\/S0014-2999(00)00659-2_BIB24","first-page":"55","article-title":"Oxcarbazepinearbazepine: mechanisms of action","volume":"35","author":"McLean","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/S0014-2999(00)00659-2_BIB25","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1097\/00127893-199809010-00007","article-title":"Cognitive effects of the new antiepileptic drugs","volume":"4","author":"Meador","year":"1998","journal-title":"Neurologist"},{"key":"10.1016\/S0014-2999(00)00659-2_BIB26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/j.1528-1157.1997.tb01479.x","article-title":"Protective effect of zonisamide, an antiepileptic drug, against transient focal cerebral ischemia with middle cerebral artery occlusion\u2013reperfusion in rats","volume":"38","author":"Minato","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/S0014-2999(00)00659-2_BIB27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0920-1211(98)00015-1","article-title":"Gabapentin and carbamazepine affect eye movements and posture control differently: a placebo-controlled investigation of acute CNS side effects in healthy volunteers","volume":"31","author":"Noachtar","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB28","first-page":"539","article-title":"Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine","volume":"286","author":"Nonaka","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0920-1211(95)00093-3","article-title":"Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala","volume":"24","author":"Pitk\u00e4nen","year":"1996","journal-title":"Epilepsy Res."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0304-3940(94)90652-1","article-title":"Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents","volume":"172","author":"Rataud","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB31","first-page":"223","article-title":"Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds","volume":"42","author":"Rogawski","year":"1990","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB32","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1056\/NEJM199011223232107","article-title":"The evaluation and treatment of seizures","volume":"323","author":"Scheuer","year":"1990","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB33","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.1528-1157.1995.tb00958.x","article-title":"Action of GP 47779, the active metabolite of oxcarbazepinearbazepine, on the corticostriatal system: II. Modulation of high-voltage-activated calcium currents","volume":"336","author":"Stefani","year":"1995","journal-title":"Epilepsia"},{"key":"10.1016\/S0014-2999(00)00659-2_BIB34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0009-2797(98)00110-0","article-title":"Carbamazepine induces multiple cytochrome P450 subfamilies in rats","volume":"117","author":"Tateishi","year":"1999","journal-title":"Chem. Biol. Int."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2174\/1381612802666220925203150","article-title":"Voltage-gated Na+ channels as targets for anticonvulsant, analgesic and neuroprotective drugs","volume":"2","author":"Taylor","year":"1996","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/S0014-2999(00)00659-2_BIB36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00004850-199707000-00007","article-title":"Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients","volume":"12","author":"Yasui","year":"1997","journal-title":"Int. Clin. Psychopharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299900006592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299900006592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,9]],"date-time":"2023-04-09T09:03:02Z","timestamp":1681030982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299900006592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S0014299900006592"],"URL":"https:\/\/doi.org\/10.1016\/s0014-2999(00)00659-2","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}