{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T10:19:59Z","timestamp":1770545999745,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[1999,9]]},"DOI":"10.1016\/s0028-3908(99)00042-8","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T23:57:31Z","timestamp":1027641451000},"page":"1371-1380","source":"Crossref","is-referenced-by-count":35,"title":["Interaction between l-DOPA and 3-O-methyl-l-DOPA for transport in immortalised rat capillary cerebral endothelial cells"],"prefix":"10.1016","volume":"38","author":[{"given":"P.","family":"Gomes","sequence":"first","affiliation":[]},{"given":"P.","family":"Soares-da-Silva","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0028-3908(99)00042-8_BIB1","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1212\/WNL.44.8.1491","article-title":"Effect of plasma levels of large neutral amino acids and degree of parkinsonism on the blood-to-brain transport of levodopa in naive and MPTP parkinsonian monkeys","volume":"44","author":"Alexander","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/S0028-3908(99)00042-8_BIB2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1471-4159.1986.tb04527.x","article-title":"Characteristics of the large neutral amino acid transport system of bovine brain microvessel endothelial cell monolayers","volume":"47","author":"Audus","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB3","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1046\/j.1471-4159.1996.67030988.x","article-title":"Functional expression of P-glycoprotein in an immortalised cell line of rat brain endothelial cells, RBE4","volume":"67","author":"Begley","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Analyt. Biochem."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB5","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","article-title":"Relationship between the inhibition constant (Ki) and the concentration of the inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction","volume":"22","author":"Cheng","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3940(97)00679-4","article-title":"Modulation of P-glycoprotein activity by glial factors and retinoic acid in an immortalized rat brain microvessel endothelial cell line","volume":"236","author":"El Hafny","year":"1997","journal-title":"Neurosci Lett."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB7","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1136\/jnnp.52.9.1063","article-title":"The effects of oral protein on the absorption of intraduodenal levodopa and motor performance","volume":"52","author":"Frankel","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/S0028-3908(99)00042-8_BIB8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(76)90932-X","article-title":"Importance of O-methylation in dopamine-induced motor and behavioral phenomena","volume":"105","author":"Furgeson","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1212\/WNL.33.3.278","article-title":"Effects of 3-OM-dopa on monoamine metabolism in rat brain","volume":"33","author":"Gervas","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/S0028-3908(99)00042-8_BIB10","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/ana.410310611","article-title":"3-O-methyldopa administration does not alter fluorodopa transport into the brain","volume":"31","author":"Guttman","year":"1992","journal-title":"Ann. Neurol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/BF01923483","article-title":"The COMT inhibitor tolcapone potentiates the anticataleptic effect of Madopar in MPP(+)-lesioned mice","volume":"50","author":"Himori","year":"1994","journal-title":"Experientia"},{"key":"10.1016\/S0028-3908(99)00042-8_BIB12","first-page":"289","article-title":"Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's disease","volume":"247","author":"Linden","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0165-6147(89)90075-8","article-title":"New selective COMT inhibitors: useful adjuncts for Parkinson's disease ?","volume":"10","author":"M\u00e4nnist\u00f6","year":"1989","journal-title":"Trends in Pharmacol. Sci."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB14","series-title":"GraphPad Prism (version 1.0)","author":"Motulsky","year":"1994"},{"key":"10.1016\/S0028-3908(99)00042-8_BIB15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00002826-198403000-00002","article-title":"Pharmacokinetics of levodopa","volume":"7","author":"Nutt","year":"1984","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/jnnp.52.4.481","article-title":"Influence of fluctuations of plasma large neutral amino acids with normal diets on the clinical response to levodopa","volume":"52","author":"Nutt","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/S0028-3908(99)00042-8_BIB17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/ana.410210610","article-title":"3-O-methyldopa and the response to levodopa in Parkinson's disease","volume":"21","author":"Nutt","year":"1987","journal-title":"Ann. Neurol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0169-409X(95)00003-P","article-title":"Transport of small molecules through the blood-brain barrier: biology and methodology","volume":"15","author":"Pardridge","year":"1995","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/S0028-3908(99)00042-8_BIB19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1471-4159.1977.tb07702.x","article-title":"Transport of metabolic substrates through the blood-brain barrier","volume":"28","author":"Pardridge","year":"1977","journal-title":"J. Neurochem."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ana.410120310","article-title":"3-O-methyldopa blocks dopa metabolism in rat corpus striatum","volume":"12","author":"Reches","year":"1982","journal-title":"Ann. Neurol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB21","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1212\/WNL.32.8.887","article-title":"3-O-methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathway","volume":"32","author":"Reches","year":"1982","journal-title":"Neurology"},{"key":"10.1016\/S0028-3908(99)00042-8_BIB22","first-page":"278","article-title":"Catechol-O-methyltransferase activity: a determinant of levodopa response","volume":"28","author":"Reilly","year":"1980","journal-title":"Clin. Exp. Pharmacol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1001\/archneur.1977.00500160042007","article-title":"The clinical picture and plasma levodopa metabolite profile of parkinsonian non-responders","volume":"34","author":"Rivera-Calimlim","year":"1977","journal-title":"Arch. Neurol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/jcp.1041590114","article-title":"Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells","volume":"159","author":"Roux","year":"1994","journal-title":"J. Cell Physiol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB25","doi-asserted-by":"crossref","first-page":"25951","DOI":"10.1016\/S0021-9258(18)35701-6","article-title":"Neutral amino acid transport by the blood-brain barrier. Membrane vesicle studies","volume":"267","author":"Sanchez del Pino","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0024-3205(73)90367-6","article-title":"Effect of chronic administration of l-DOPA on catechol-O-methyltransferase in rat tissues","volume":"12","author":"Sharpless","year":"1973","journal-title":"Life Sci."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1476-5381.1994.tb13118.x","article-title":"Cell inward transport of l-DOPA and 3-O-methyl-l-DOPA in rat renal tubules","volume":"112","author":"Soares-da-Silva","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB28","first-page":"F243","article-title":"Apical and basolateral uptake and intracellular fate of dopamine precursor l-dopa in LLC-PK1 cells","volume":"274","author":"Soares-da-Silva","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB29","first-page":"F632","article-title":"Apical and basal uptake of l-dopa and l-5-HTP and their corresponding amines, dopamine and 5-HT, in OK cells","volume":"272","author":"Vieira-Coelho","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB30","doi-asserted-by":"crossref","first-page":"C104","DOI":"10.1152\/ajpcell.1998.275.1.C104","article-title":"Uptake and intracellular fate of l-3,4-dihydroxyphenylalanine, the dopamine precursor in a human intestinal epithelial cells line: Caco-2","volume":"275","author":"Vieira-Coelho","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0024-3205(75)90248-9","article-title":"3-O-methyldopa uptake and inhibition of l-DOPA at the blood-brain barrier","volume":"17","author":"Wade","year":"1975","journal-title":"Life Sci."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB32","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1471-4159.1975.tb04415.x","article-title":"Synthetic amino acids and the nature of l-DOPA transport at the blood\u2013brain barrier","volume":"25","author":"Wade","year":"1975","journal-title":"J. Neurochem."},{"key":"10.1016\/S0028-3908(99)00042-8_BIB33","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1212\/WNL.43.9.1704","article-title":"The effect of L-dopa infusions with and without phenylalanine challenges in parkinsonian patients: plasma and ventricular CSF L-dopa levels and clinical responses","volume":"43","author":"Woodward","year":"1993","journal-title":"Neurology"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390899000428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390899000428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T08:23:51Z","timestamp":1620894231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390899000428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1999,9]]}},"alternative-id":["S0028390899000428"],"URL":"https:\/\/doi.org\/10.1016\/s0028-3908(99)00042-8","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[1999,9]]}}}