{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:08:16Z","timestamp":1776276496274,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5372,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1998,11]]},"DOI":"10.1016\/s0092-8674(00)81635-9","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T05:39:29Z","timestamp":1081575569000},"page":"649-655","source":"Crossref","is-referenced-by-count":376,"title":["Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus"],"prefix":"10.1016","volume":"95","author":[{"given":"Jo\u00e3o H.Morais","family":"Cabral","sequence":"first","affiliation":[]},{"given":"Alice","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Steven L","family":"Cohen","sequence":"additional","affiliation":[]},{"given":"Brian T","family":"Chait","sequence":"additional","affiliation":[]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[]},{"given":"Roderick","family":"Mackinnon","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81635-9_BIB1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0263-7855(98)80030-1","article-title":"A fast algorithm for rendering space-filling molecule pictures","volume":"6","author":"Bacon","year":"1988","journal-title":"J. Mol. Graph."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB2","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1128\/jb.179.12.4075-4079.1997","article-title":"A signal transducer for aerotaxis in Escherichia coli","volume":"179","author":"Bibikov","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB3","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1021\/bi00019a004","article-title":"1.4 \u00c5 structure of photoactive yellow protein, a cytosolic photoreceptor","volume":"34","author":"Borgstahl","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB4","unstructured":"Brunger, A.T. (1996). X-PLOR (version 3.851) Manual. (The Howard Hughes Medical Institute and Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT)."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB33","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","article-title":"The CCP4 suite","volume":"50","author":"Collaborative computational project 4","year":"1994","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB5","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0969-2126(00)00047-2","article-title":"Mass-spectrometry \u2014 a useful tool for the protein X-ray crystallographer and NMR spectroscopist","volume":"2","author":"Chait","year":"1994","journal-title":"Structure"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB6","first-page":"34","article-title":"DM","volume":"4","author":"Cowtan","year":"1994","journal-title":"Joint CCP"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB7","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0092-8674(95)90358-5","article-title":"A molecular basis for cardiac arrhythmia","volume":"80","author":"Curran","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB8","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.275.5305.1471","article-title":"Structure of a protein photocycle intermediate by millisecond time-resolved crystallography","volume":"275","author":"Genick","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB9","doi-asserted-by":"crossref","first-page":"13743","DOI":"10.1073\/pnas.94.25.13743","article-title":"Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family","volume":"94","author":"Hahn","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB10","first-page":"3600","article-title":"The FSSP data base of structurally aligned protein fold families","volume":"22","author":"Holm","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","article-title":"Improved methods for building protein models in electron density maps and the location of errors in the models","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB12","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","article-title":"MOLSCRIPT","volume":"24","author":"Kraulis","year":"1991","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/31978","article-title":"Crystal structure of the tetramerization domain of the Shaker potassium channel","volume":"392","author":"Kreusch","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB14","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1074\/jbc.272.2.705","article-title":"The human \u03941261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression","volume":"272","author":"Li","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0076-6879(97)77028-9","article-title":"RASTER3D","volume":"277","author":"Merritt","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB16","unstructured":"Otwinowski, Z. (1993). Oscillation data reduction program. In Data Collection and Processing, L.Sawyer, N.Isaacs, and S. Bailey, eds. (Daresbury Laboratory, Daresbury, UK: Science and Engineering Research Council), pp. 56\u201362."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB17","doi-asserted-by":"crossref","first-page":"5884","DOI":"10.1073\/pnas.95.11.5884","article-title":"Photoactive yellow protein","volume":"95","author":"Pellequer","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB18","doi-asserted-by":"crossref","first-page":"R674","DOI":"10.1016\/S0960-9822(06)00352-6","article-title":"PAS","volume":"7","author":"Ponting","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB19","doi-asserted-by":"crossref","first-page":"10541","DOI":"10.1073\/pnas.94.20.10541","article-title":"The AER protein and the serine chemoreceptor TSR independently sense intracellular energy levels and transduce oxygen, redox and energy signals for Escherichia coli","volume":"94","author":"Rebbapragada","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB20","first-page":"1","article-title":"A clockwork explosion!","volume":"21","author":"Reppert","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(95)90340-2","article-title":"A mechanistic link between an inherited and an acquired cardiac arrhythmia","volume":"81","author":"Sanguinetti","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB22","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/31821","article-title":"Molecular clocks","volume":"392","author":"Sassone-Corsi","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB23","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1113\/jphysiol.1996.sp021410","article-title":"Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel","volume":"493","author":"Sch\u00f6nherr","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033583500002894","article-title":"Voltage gating of ion channels","volume":"27","author":"Sigworth","year":"1994","journal-title":"Q. Rev. Biophys."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1107\/S0108767390000277","article-title":"Phase annealing in SHELX-90","volume":"46","author":"Sheldrick","year":"1990","journal-title":"Acta Crystallogr."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB26","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/379833a0","article-title":"The inward rectification mechanism of the HERG cardiac potassium channel","volume":"379","author":"Smith","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1085\/jgp.107.5.611","article-title":"Fast inactivation causes rectification of the IKr channel","volume":"107","author":"Spector","year":"1996","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB28","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1469-7793.1997.537bj.x","article-title":"Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment","volume":"502","author":"Terlau","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/S0092-8674(00)81635-9_BIB29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.7604285","article-title":"HERG, a human inward rectifier in the voltage-gated potassium channel family","volume":"269","author":"Trudeau","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB30","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1073\/pnas.91.8.3438","article-title":"A family of potassium channel genes related to eag in Drosophila and mammals","volume":"91","author":"Warmke","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB31","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1126\/science.1840699","article-title":"A distinct potassium channel polypeptide by the Drosophila eag locus","volume":"252","author":"Warmke","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81635-9_BIB32","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0968-0004(97)01110-9","article-title":"PAS domain S-boxes in Archae, Bacteria and sensors for oxygen and redox","volume":"22","author":"Zhulin","year":"1997","journal-title":"Trends Biochem. Sci."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400816359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400816359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T01:01:12Z","timestamp":1550106072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400816359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,11]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,11]]}},"alternative-id":["S0092867400816359"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81635-9","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1998,11]]}}}