{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:52:32Z","timestamp":1791579152500,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/s0140-6736(26)01296-1","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:03:58Z","timestamp":1791500638000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial"],"prefix":"10.1016","author":[{"given":"Marc A","family":"Riedl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip H","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Adatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Cancian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Stobiecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Valerieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anete S","family":"Grumach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Lumry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F","family":"Soteres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Brodszki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia L","family":"Fili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Hakl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Ryun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gul","family":"Karakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birger","family":"Kr\u00e4nke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Henry","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonny","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Recke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffi","family":"Tachdjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Triggianese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zanichelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Ayg\u00f6ren-P\u00fcrs\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Giardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Giavina-Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Kinaciyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Martinez-Saguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Perego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl V","family":"Sitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Staevska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H James","family":"Wedner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael H","family":"Zaragoza-Urdaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo D","family":"Zwiener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Gelincik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Arcoleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rand","family":"Arnaout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan P","family":"Baptist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"de Albuquerque Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D","family":"Dorr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Paes Leme","family":"Ferriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Fukunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Gobert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmalal","family":"Gurugama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Hide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Inage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance H","family":"Katelaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Leeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Lleonart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Magerl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Manning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Mano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seido","family":"Ooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina J","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Mendivil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar","family":"Katbeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Giannattasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Crabb\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lesage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny M","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(26)01296-1_bib1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.anai.2020.02.018","article-title":"Patient-reported burden of hereditary angioedema: findings from a patient survey in the United States","volume":"124","author":"Banerji","year":"2020","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s12016-016-8575-2","article-title":"The humanistic, societal, and pharmaco-economic burden of angioedema","volume":"51","author":"Longhurst","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"issue":"suppl 1","key":"10.1016\/S0140-6736(26)01296-1_bib3","doi-asserted-by":"crossref","first-page":"S08","DOI":"10.2500\/aap.2020.41.200050","article-title":"Hereditary angioedema: epidemiology and burden of disease","volume":"41","author":"Lumry","year":"2020","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/S0140-6736(26)01296-1_bib4","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1808012","article-title":"Hereditary angioedema","volume":"382","author":"Busse","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(26)01296-1_bib5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaip.2020.08.046","article-title":"US HAEA Medical Advisory Board 2020 guidelines for the management of hereditary angioedema","volume":"9","author":"Busse","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"suppl","key":"10.1016\/S0140-6736(26)01296-1_bib6","first-page":"S292","article-title":"Severity of hereditary angioedema, prevalence, and diagnostic considerations","volume":"24","author":"Bernstein","year":"2018","journal-title":"Am J Manag Care"},{"key":"10.1016\/S0140-6736(26)01296-1_bib7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.anai.2025.01.007","article-title":"Hereditary angioedema: patient health care experiences within underrepresented racial and ethnic groups in the United States","volume":"134","author":"Craig","year":"2025","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib8","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1111\/all.15214","article-title":"The international WAO\/EAACI guideline for the management of hereditary angioedema\u2014the 2021 revision and update","volume":"77","author":"Maurer","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/S0140-6736(26)01296-1_bib9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.12968\/hmed.2019.80.7.391","article-title":"Hereditary angioedema: an update on causes, manifestations and treatment","volume":"80","author":"Longhurst","year":"2019","journal-title":"Br J Hosp Med (Lond)"},{"key":"10.1016\/S0140-6736(26)01296-1_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.anai.2010.01.007","article-title":"The bradykinin-forming cascade and its role in hereditary angioedema","volume":"104","author":"Kaplan","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib11","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jaip.2025.02.036","article-title":"Hereditary angioedema with normal C1 inhibitor: a quarter century of forward progress and persisting obstacles","volume":"13","author":"Christiansen","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/S0140-6736(26)01296-1_bib12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s12016-025-09027-4","article-title":"Hereditary angioedema with normal C1 inhibitor: an updated international consensus paper on diagnosis, pathophysiology, and treatment","volume":"68","author":"Zuraw","year":"2025","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib13","series-title":"Ekterly (sebetralstat); prescribing information","year":"2025"},{"key":"10.1016\/S0140-6736(26)01296-1_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1056\/NEJMoa2314192","article-title":"Oral sebetralstat for on-demand treatment of hereditary angioedema attacks","volume":"391","author":"Riedl","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(26)01296-1_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1067\/mai.2002.121316","article-title":"Pathways for bradykinin formation and inflammatory disease","volume":"109","author":"Kaplan","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib16","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/cea.14206","article-title":"The icatibant outcome survey: 10\u2008years of experience with icatibant for patients with hereditary angioedema","volume":"52","author":"Maurer","year":"2022","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/S0140-6736(26)01296-1_bib17","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJMoa0906393","article-title":"Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema","volume":"363","author":"Cicardi","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(26)01296-1_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13223-025-00969-0","article-title":"Factors contributing to non-compliance with on-demand treatment guidelines in hereditary angioedema","volume":"21","author":"Betschel","year":"2025","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib19","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.2500\/aap.2021.42.210025","article-title":"Patient perspectives on the treatment burden of injectable medication for hereditary angioedema","volume":"42","author":"Radojicic","year":"2021","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/S0140-6736(26)01296-1_bib20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13023-025-03539-0","article-title":"The adolescent experience of hereditary angioedema: a qualitative study of disease burden and treatment experience","volume":"20","author":"Broderick","year":"2025","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/S0140-6736(26)01296-1_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/futurepharmacol4010005","article-title":"Hereditary angioedema: novel molecules for treatment of acute attacks and long-term prophylaxis","volume":"4","author":"Covella","year":"2024","journal-title":"Future Pharmacol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib22","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1016\/j.jaip.2025.08.020","article-title":"Long-term safety and effectiveness of sebetralstat: interim analysis of KONFIDENT-S open-label extension","volume":"13","author":"Farkas","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/S0140-6736(26)01296-1_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/clt2.12391","article-title":"Advent of oral medications for the treatment of hereditary angioedema","volume":"14","author":"Valerieva","year":"2024","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/S0140-6736(26)01296-1_bib24","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1016\/S2352-3026(26)00004-9","article-title":"Oral deucrictibant for prophylaxis of hereditary angioedema attacks (CHAPTER-1): primary analysis of a randomised, double-blind, placebo-controlled, phase 2 trial","volume":"13","author":"Ayg\u00f6ren-P\u00fcrs\u00fcn","year":"2026","journal-title":"Lancet Haematol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib25","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1016\/S2352-3026(25)00341-2","article-title":"Oral deucrictibant for on-demand treatment of hereditary angioedema attacks (RAPIDe-1): a randomised, double-blind, placebo-controlled, phase 2 trial","volume":"13","author":"Maurer","year":"2026","journal-title":"Lancet Haematol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib26","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.jaip.2024.04.007","article-title":"A core outcome set for efficacy of acute treatment of hereditary angioedema","volume":"12","author":"Petersen","year":"2024","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/S0140-6736(26)01296-1_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/clt2.12288","article-title":"Evaluation of patient-reported outcome measures for on-demand treatment of hereditary angioedema attacks and design of KONFIDENT, a phase 3 trial of sebetralstat","volume":"13","author":"Cohn","year":"2023","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/S0140-6736(26)01296-1_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12016-025-09132-4","article-title":"Assessing patient-reported outcomes in acute attacks of hereditary angioedema: insights from a mixed methods study of participants receiving standard-of-care treatments in a real-world setting","volume":"69","author":"Mendivil","year":"2026","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib29","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/(SICI)1097-0258(19960530)15:10<953::AID-SIM213>3.0.CO;2-M","article-title":"Cross-over trials with censored data","volume":"15","author":"Feingold","year":"1996","journal-title":"Stat Med"},{"key":"10.1016\/S0140-6736(26)01296-1_bib30","first-page":"203","article-title":"Modeling cost-effectiveness of on-demand treatment for hereditary angioedema attacks","volume":"26","author":"Bernstein","year":"2020","journal-title":"J Manag Care Spec Pharm"},{"key":"10.1016\/S0140-6736(26)01296-1_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/falgy.2022.952233","article-title":"Treatment of hereditary angioedema-single or multiple pathways to the rescue","volume":"3","author":"Valerieva","year":"2022","journal-title":"Front Allergy"},{"key":"10.1016\/S0140-6736(26)01296-1_bib32","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.jaci.2025.07.033","article-title":"Long-term prophylactic treatment with deucrictibant for angioedema due to acquired C1-inhibitor deficiency","volume":"156","author":"de Lange","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib33","first-page":"S31","article-title":"Outcomes of deucrictibant-treated upper airway and laryngeal hereditary angioedema attacks: RAPIDe-2 part A results","volume":"135","author":"Anderson","year":"2025","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib34","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.anai.2025.08.105","article-title":"Sustained therapeutic exposure with once-daily oral deucrictibant extended-release tablet for prophylaxis of hereditary angioedema attacks","volume":"135","author":"Zhang","year":"2025","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/cpdd.138","article-title":"Pharmacokinetics of single and repeat doses of icatibant","volume":"4","author":"Leach","year":"2015","journal-title":"Clin Pharmacol Drug Dev"},{"key":"10.1016\/S0140-6736(26)01296-1_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108523","article-title":"In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B2 receptor antagonist in clinical development","volume":"105","author":"Lesage","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/S0140-6736(26)01296-1_bib38","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.anai.2011.08.015","article-title":"Randomized placebo-controlled trial of the bradykinin B2 receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial","volume":"107","author":"Lumry","year":"2011","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673626012961?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673626012961?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:31:21Z","timestamp":1791577881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673626012961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":37,"alternative-id":["S0140673626012961"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(26)01296-1","relation":{},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial","name":"articletitle","label":"Article Title"},{"value":"The Lancet","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0140-6736(26)01296-1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/S0140-6736(26)01855-6","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}