{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:20:22Z","timestamp":1776406822678,"version":"3.51.2"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1016\/s0168-3659(03)00033-6","type":"journal-article","created":{"date-parts":[[2003,4,25]],"date-time":"2003-04-25T02:16:19Z","timestamp":1051236979000},"page":"199-212","source":"Crossref","is-referenced-by-count":132,"title":["Comparison of dissolution profiles of Ibuprofen pellets"],"prefix":"10.1016","volume":"89","author":[{"given":"F.O.","family":"Costa","sequence":"first","affiliation":[]},{"given":"J.J.S.","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"A.A.C.C.","family":"Pais","sequence":"additional","affiliation":[]},{"given":"S.J.","family":"Formosinho","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0168-3659(03)00033-6_BIB1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/jps.2600521210","article-title":"Mechanisms of sustained-action medication: theoretical analysis of rate of release of solid drug disperse in solid matrices","volume":"52","author":"Higuchi","year":"1963","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB2","first-page":"164","article-title":"In vitro\/in vivo correlation of dissolution using moments of dissolution and transit times","volume":"32","author":"Brockmeier","year":"1986","journal-title":"Acta Pharm. Technol."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB3","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1021\/js960473x","article-title":"Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartarate tablets","volume":"86","author":"Polli","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB4","first-page":"157","article-title":"Role of dissolution studies in controlled release drug delivery systems","volume":"9","author":"Sood","year":"1999","journal-title":"STP Pharm. Sci."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0378-5173(00)00581-0","article-title":"Evaluation of dissolution profiles using principal component analysis","volume":"212","author":"Adams","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0928-0987(00)00174-3","article-title":"Cause of high variability in drug dissolution testing and its impact on setting tolerances","volume":"12","author":"Qureshi","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0939-6411(01)00213-2","article-title":"Typical variability and evaluation of sources of variability in drug dissolution testing","volume":"53","author":"Siewert","year":"2002","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0378-5173(01)00921-8","article-title":"The influence of core materials and film coating on the drug release from coated pellets","volume":"233","author":"Sousa","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB9","unstructured":"Note for Guidance on Quality of Modified Release Products: A. Oral Dosage Forms; B. Transdermal Dosage Forms; Section I (Quality), EMEA Committee for Proprietary Medicinal Products (CPMP), London, UK, 1999."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB10","unstructured":"Guidance for Industry: Dissolution Testing of Immediate Release Solid Oral Dosage Forms, FDA Center for Drug Evaluation and Research, Rockville, MD, 1997."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0378-5173(93)90129-4","article-title":"Comparison of in vitro dissolution profiles by calculating mean dissolution time (MDT), or mean residence time (MRT)","volume":"97","author":"Podczeck","year":"1993","journal-title":"Int. J. Pharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1248\/cpb.45.171","article-title":"The use of statistical moment analysis to elucidate the mechanism of release of a model drug from pellets produced by extrusion and spheronization","volume":"45","author":"Pinto","year":"1997","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-5173(00)00554-8","article-title":"Comparison of in vitro dissolution profiles by anova-based, model-dependent and -independent methods","volume":"209","author":"Yuksel","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB14","first-page":"64","article-title":"Mathematical comparison of dissolution profiles","volume":"20","author":"Moore","year":"1996","journal-title":"Pharm. Tech."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0168-3659(98)00022-4","article-title":"Evaluation and comparison of dissolution data derived from different modified release dosage forms: an alternative method","volume":"55","author":"Pillay","year":"1998","journal-title":"J. Controlled Release"},{"key":"10.1016\/S0168-3659(03)00033-6_BIB16","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1023\/A:1011976615750","article-title":"In vitro dissolution profile comparison-statistics and analysis of the similarity factor, f2","volume":"15","author":"Shah","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB17","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1081\/DDC-100107244","article-title":"Influence of dissolution medium agitation on release profiles of sustained-release tablets","volume":"27","author":"Costa","year":"2001","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0168-3659(01)00356-X","article-title":"Application of multiple response optimization technique to extend release formulations design","volume":"73","author":"Hamed","year":"2001","journal-title":"J. Controlled Release"},{"key":"10.1016\/S0168-3659(03)00033-6_BIB19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0378-5173(01)00651-2","article-title":"An alternative method to the evaluation of similarity factor in dissolution testing","volume":"220","author":"Costa","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0378-5173(95)04356-X","article-title":"Nonlinear data fitting for controlled release devices: an integrated computer program","volume":"129","author":"Lu","year":"1996","journal-title":"Int. J. Pharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0168-3659(00)00349-7","article-title":"Mechanistic modeling of drug release from chitosan coated tablets","volume":"70","author":"Koizumi","year":"2001","journal-title":"J. Controlled Release"},{"key":"10.1016\/S0168-3659(03)00033-6_BIB22","first-page":"273","article-title":"Evaluation of gum karaya as a carrier in the design of oral controlled-released hydrophilic matrix systems","volume":"51","author":"Babu","year":"2001","journal-title":"Acta Pharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB23","unstructured":"AHFH Drug Information, American Society of Health-System Pharmacists, Maryland, 2002."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB24","first-page":"73","article-title":"Statistical modelling of ibuprofen release from spherical lipophilic matrices","volume":"40","author":"Su","year":"1994","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0928-0987(01)00095-1","article-title":"Modeling and comparison of dissolution profiles","volume":"13","author":"Costa","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01117450","article-title":"Application of akaike\u2019s information criterion (AIC), in the evaluation of linear pharmacokinetic equations","volume":"6","author":"Yamaoka","year":"1978","journal-title":"J. Pharmacokin. Biopharm."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB27","unstructured":"J.J.M.S. Sousa, The influence of formulation on the formation of and drug release from film coated pellets, PhD Thesis, University of Loudou, 1996."},{"key":"10.1016\/S0168-3659(03)00033-6_BIB28","series-title":"Chemometrics: A Textbook","author":"Massart","year":"1988"},{"key":"10.1016\/S0168-3659(03)00033-6_BIB29","series-title":"Applied Statistics, a Handbook of Techniques","author":"Sachs","year":"1982"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365903000336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365903000336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T21:53:37Z","timestamp":1553205217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365903000336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S0168365903000336"],"URL":"https:\/\/doi.org\/10.1016\/s0168-3659(03)00033-6","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}