{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:25:27Z","timestamp":1762640727716},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2001,5]]},"DOI":"10.1016\/s0198-8859(01)00233-6","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T21:59:10Z","timestamp":1027634350000},"page":"488-499","source":"Crossref","is-referenced-by-count":21,"title":["T-Cell receptor repertoire in hereditary hemochromatosis: a study of 32 hemochromatosis patients and 274 healthy subjects"],"prefix":"10.1016","volume":"62","author":[{"given":"Carla","family":"Cardoso","sequence":"first","affiliation":[]},{"given":"Gra\u00e7a","family":"Porto","sequence":"additional","affiliation":[]},{"given":"Rosa","family":"Lacerda","sequence":"additional","affiliation":[]},{"given":"Dolores","family":"Resende","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Fernanda","family":"Bravo","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Carlos","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Benvindo","family":"Justi\u00e7a","sequence":"additional","affiliation":[]},{"given":"Maria","family":"de Sousa","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0198-8859(01)00233-6_BIB1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1056\/NEJM197912063012319","article-title":"Genetics of hemochromatosis","volume":"301","author":"Cartwright","year":"1979","journal-title":"N Engl J Med"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1600-0609.1989.tb01200.x","article-title":"Hereditary hemochromatosis","volume":"42","author":"Cox","year":"1989","journal-title":"Eur J Haematol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB3","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJM198805263182103","article-title":"Prevalence of hemochromatosis among 11,065 presumably healthy blood donors","volume":"318","author":"Edwards","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng0896-399","article-title":"A novel MHC class I like gene is mutated in patients with hereditary haemochromatosis","volume":"13","author":"Feder","year":"1996","journal-title":"Nature Genet"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB5","doi-asserted-by":"crossref","first-page":"14025","DOI":"10.1074\/jbc.272.22.14025","article-title":"The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression","volume":"272","author":"Feder","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB6","doi-asserted-by":"crossref","unstructured":"Porto G, de Sousa M: Variation of hemochromatosis prevalence and genotype in national groups. In Barton JC, Edwards CQ (eds): Hemochromatosis: genetics, pathophysiology, diagnosis and treatment. Cambridge, UK: Cambridge University Press, 2000.","DOI":"10.1017\/CBO9780511666476.006"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB7","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/jmg.34.9.761","article-title":"Homozygosity for the predominant Cys282Tyr mutation and absence of disease expression in hereditary hemochromatosis","volume":"34","author":"Rhodes","year":"1997","journal-title":"J Med Genet"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB8","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0016-5085(98)70320-8","article-title":"Expression of HLA-linked hemochromatosis in subjects homozygous or heterozygous for the C282Y mutation","volume":"114","author":"Crawford","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/hep.510280233","article-title":"Clinical characteristics of hereditary hemochromatosis patients who lack the C282Y mutation","volume":"28","author":"Shaheen","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB10","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1056\/NEJM199909023411003","article-title":"Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene","volume":"341","author":"Pietrangelo","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1600-0609.1994.tb00097.x","article-title":"Haemochromatosis as window into the study of the immunological system","volume":"52","author":"Porto","year":"1994","journal-title":"Eur J Haematol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/hep.510250223","article-title":"Relative impact of HLA phenotype and CD4\/CD8 ratios on the clinical expression of hemochromatosis","volume":"25","author":"Porto","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1365-3083.1994.tb03396.x","article-title":"Decreased CD8-p56lck activity in peripheral blood T-lymphocytes from patients with hereditary haemochromatosis","volume":"39","author":"Arosa","year":"1994","journal-title":"Scand J Immunol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB14","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1046\/j.1365-2249.1997.d01-967.x","article-title":"Anomalies of the CD8+ T cell pool in haemochromatosis","volume":"107","author":"Arosa","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0165-2478(94)90094-9","article-title":"Iron overload in \u03b22-microglobulin deficient mice","volume":"39","author":"de Sousa","year":"1994","journal-title":"Immunol Lett"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB16","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1084\/jem.184.5.1975","article-title":"Defective iron \u03b22-microglobulin knock-out mice recapitulates hereditary hemochromatosis in man","volume":"184","author":"Santos","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1600-065X.1999.tb01395.x","article-title":"Gamma delta intraepithelial lymphocytes drive tumor necrosis factor-alpha responsiveness to intestinal iron challenge","volume":"167","author":"Ten Elshof","year":"1999","journal-title":"Immunol Rev"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB18","doi-asserted-by":"crossref","unstructured":"Santos M, Clevers H, Marx JJM, de Sousa M: Iron overload and Heart fibrosis in \u03b22-microglobulin and Rag1-deficient mice. Am J Pathol 157:1883, 2000.","DOI":"10.1016\/S0002-9440(10)64827-4"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB19","doi-asserted-by":"crossref","first-page":"13312","DOI":"10.1073\/pnas.96.23.13312","article-title":"Experimental hemochromatosis due to MHC class I HFE deficiency","volume":"96","author":"Bahram","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB20","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1172\/JCI9635","article-title":"Genes that modify the hemochromatosis phenotype in mice","volume":"105","author":"Levy","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-8278(98)80367-X","article-title":"The immunology of hemochromatosis","volume":"28","author":"de Sousa","year":"1998","journal-title":"J Hepatol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB22","doi-asserted-by":"crossref","unstructured":"EASL International Consensus Conference in Haemochromatosis. J Hepatol 33:485, 2000.","DOI":"10.1016\/S0168-8278(00)80288-3"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB23","doi-asserted-by":"crossref","unstructured":"Barton JC, McDonnell SM, Adams PC, Brissot P, Powell LW, Edwards CQ, Cook JD, Kowdley KV, and the Hemochromatosis Management Working Group: Management of hemochromatosis. Ann Intern Med 129:932, 1998.","DOI":"10.7326\/0003-4819-129-11_Part_2-199812011-00003"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB24","doi-asserted-by":"crossref","unstructured":"Esin S, Gul A, Hodara V, Jeddi-Tehrani M, Dilsen N, Koni\u00e7e M, Andersson R, Wigzell: Peripheral blood T cell expansions in patients with Behcet\u2019s disease. Clin Exp Immunol 107: 520, 1997.","DOI":"10.1046\/j.1365-2249.1997.d01-947.x"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00000374-200004000-00027","article-title":"Expansions of CD8+CD28\u2212 and CD8+TcRVbeta5","volume":"24","author":"Arosa","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB26","first-page":"779","article-title":"Method for establishing serum ferritin reference values depending on sex and age","volume":"116","author":"Vicente","year":"1990","journal-title":"J Lab Clin Med"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB27","first-page":"295","article-title":"Importance of establishing appropriate local reference values for the screening of hemochromatosis","volume":"119","author":"Porto","year":"1992","journal-title":"J Lab Clin Med"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/370463a0","article-title":"Major expansion of CD8+ T cells with predominant V\u03b2 usage during primary immune response to HIV","volume":"370","author":"Pantaleo","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB29","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1046\/j.1365-2249.1997.4331451.x","article-title":"HLA-dependent peripheral T cell receptor (TCR) repertoire formation and its modification by rheumatoid arthritis (RA)","volume":"110","author":"Mizushima","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB30","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1084\/jem.177.6.1623","article-title":"Clonal V\u03b112","volume":"177","author":"DerSimonian","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB31","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.4049\/jimmunol.154.7.3538","article-title":"Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis","volume":"154","author":"Fitzgerald","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1084\/jem.179.2.609","article-title":"Clonal populations of T cell equivalent in normal elderly humans","volume":"179","author":"Posnett","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB33","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0198-8859(91)90056-F","article-title":"T-cell receptor variable beta genes show differential expression in CD4 and CD8 T cells","volume":"32","author":"Davey","year":"1991","journal-title":"Hum Immunol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB34","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/eji.1830210637","article-title":"Preferential expression of V beta 6.7 domain on human peripheral CD4+ T cells. Implication for positive selection of T cells in man","volume":"21","author":"Cossarizza","year":"1991","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB35","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.4049\/jimmunol.150.7.2761","article-title":"Influence of HLA genes on T cell receptor V segment frequencies and expression levels in peripheral blood lymphocytes","volume":"150","author":"Akolkar","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB36","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.4049\/jimmunol.154.8.3843","article-title":"Do HLA genes play a prominent role in determining T cell receptor V alpha segment usage in humans?","volume":"154","author":"Gulwani-Akolkar","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1749-6632.1995.tb44480.x","article-title":"The influence of genetics, environment, and disease state on the human T-cell receptor repertoire","volume":"756","author":"Silver","year":"1995","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB38","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1002\/eji.1830201244","article-title":"Expression of the human V beta 8 gene product preferentially correlates with class II major histocmpatibility complex restriction specificity","volume":"20","author":"Imberti","year":"1990","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB39","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/eji.1830220435","article-title":"Repertoire of V alpha and V beta regions of T cell antigen receptors on CD4+ and CD8+ peripheral blood T cells in a novel X-linked combined immunodeficiency disease","volume":"22","author":"Goldman","year":"1992","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0092-8674(00)81151-4","article-title":"Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor","volume":"93","author":"Lebron","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB41","doi-asserted-by":"crossref","unstructured":"Mullighan CG, Bunce M, Fanning GC, Marshall SE, Welsh KI. A rapid method of haplotyping HFE mutations and linkage disequilibrium in a Caucasoid population. Gut 42:566, 1998.","DOI":"10.1136\/gut.42.4.566"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB42","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1399-0039.1998.tb03076.x","article-title":"High incidence of the Cys 282 Tyr mutation in the HFE gene in the Irish population\u2014implications for haemochromatosis","volume":"52","author":"Murphy","year":"1998","journal-title":"Tissue Antigens"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB43","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s002510050376","article-title":"Major histocompatibility complex class I associations in iron overload","volume":"47","author":"Porto","year":"1998","journal-title":"Immunogenetics"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB44","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1073\/pnas.070550797","article-title":"Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70","volume":"97","author":"Moroi","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0198-8859(01)00233-6_BIB45","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.4049\/jimmunol.162.6.3141","article-title":"In vivo and in vitro activation of T cells after administration of Ag-negative heat shock proteins","volume":"162","author":"Breloer","year":"1999","journal-title":"J Immunol"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885901002336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885901002336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T14:14:57Z","timestamp":1704118497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885901002336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["S0198885901002336"],"URL":"https:\/\/doi.org\/10.1016\/s0198-8859(01)00233-6","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}