{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:59:50Z","timestamp":1775062790927,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[1998,12]]},"DOI":"10.1016\/s0223-5234(97)89637-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T15:10:52Z","timestamp":1027609852000},"page":"927-940","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Structure elucidation and conformational analysis of gonadotropin releasing hormone and its novel synthetic analogue [Tyr(OMe)5, d-Lys6, Aze9NHEtGnRH: The importance of aromatic clustering in the receptor binding activity"],"prefix":"10.1016","volume":"32","author":[{"given":"J.M.","family":"Matsoukas","sequence":"first","affiliation":[]},{"given":"M","family":"Keramida","sequence":"additional","affiliation":[]},{"given":"D","family":"Panagiotopoulos","sequence":"additional","affiliation":[]},{"given":"T","family":"Mavromoustakos","sequence":"additional","affiliation":[]},{"given":"H.L.S.","family":"Maia","sequence":"additional","affiliation":[]},{"given":"G","family":"Bigam","sequence":"additional","affiliation":[]},{"given":"D","family":"Pati","sequence":"additional","affiliation":[]},{"given":"H.R.","family":"Habibi","sequence":"additional","affiliation":[]},{"given":"G.J.","family":"Moore","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0223-5234(97)89637-7_bib1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1210\/edrv-7-1-44","volume":"7","author":"Karten","year":"1986","journal-title":"Endocrine Reviews"},{"key":"10.1016\/S0223-5234(97)89637-7_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1021\/jm00265a017","volume":"16","author":"Coy","year":"1973","journal-title":"J Med Chem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0006-291X(72)90552-9","volume":"47","author":"Chang","year":"1972","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0223-5234(97)89637-7_bib4_1","series-title":"Peptides 1994, Proceedings of the 23rd European Peptide Symposium","author":"Keramida","year":"1994"},{"key":"10.1016\/S0223-5234(97)89637-7_bib4_2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00128117","volume":"3","author":"Keramida","year":"1996","journal-title":"Lett Peptide Sci"},{"key":"10.1016\/S0223-5234(97)89637-7_bib5","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1021\/bi00383a036","volume":"26","author":"Baniak","year":"1987","journal-title":"Biochem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1432-1033.1986.tb09754.x","volume":"158","author":"Chary","year":"1986","journal-title":"Eur J Biochem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib7","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1021\/ja00034a015","volume":"114","author":"Rizo","year":"1992","journal-title":"J Am Chem Soc"},{"key":"10.1016\/S0223-5234(97)89637-7_bib8","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1021\/ja00034a016","volume":"114","author":"Rizo","year":"1992","journal-title":"J Am Chem Soc"},{"key":"10.1016\/S0223-5234(97)89637-7_bib9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.7001627","volume":"210","author":"Freidinger","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0223-5234(97)89637-7_bib10","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1021\/bi00747a012","volume":"12","author":"Monahan","year":"1973","journal-title":"Biochem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0196-9781(90)90093-K","volume":"11","author":"Matsoukas","year":"1990","journal-title":"Peptides"},{"key":"10.1016\/S0223-5234(97)89637-7_bib12","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/jlac.198919890250","author":"Barlos","year":"1989","journal-title":"Liebigs Ann Chem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0196-9781(90)90094-L","volume":"11","author":"Matsoukas","year":"1990","journal-title":"Peptides"},{"key":"10.1016\/S0223-5234(97)89637-7_bib14_1","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1016\/S0021-9258(17)37688-3","volume":"269","author":"Matsoukas","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib14_2","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1021\/jm00023a005","volume":"38","author":"Matsoukas","year":"1995","journal-title":"J Med Chem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1399-3011.1989.tb00694.x","volume":"33","author":"Bolin","year":"1989","journal-title":"Int J Pept Protein Res"},{"key":"10.1016\/S0223-5234(97)89637-7_bib16","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1021\/jm00059a016","volume":"36","author":"Matsoukas","year":"1993","journal-title":"J Med Chem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib17","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1021\/jm00044a017","volume":"37","author":"Matsoukas","year":"1994","journal-title":"J Med Chem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0020-7381(83)85073-6","volume":"49","author":"Hogg","year":"1983","journal-title":"Int J Mass Spectrom Ion Phys"},{"key":"10.1016\/S0223-5234(97)89637-7_bib19","series-title":"The Nuclear Overhauser Effect","author":"Noggle","year":"1991"},{"key":"10.1016\/S0223-5234(97)89637-7_bib20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0006-291X(83)91093-8","volume":"113","author":"Marion","year":"1983","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0223-5234(97)89637-7_bib21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0223-5234(96)88229-8","volume":"30","author":"Mavromoustakos","year":"1995","journal-title":"Eur J Med Chem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1210\/endo.136.1.7828560","volume":"136","author":"Pati","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/S0223-5234(97)89637-7_bib23","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1095\/biolreprod40.6.1152","volume":"40","author":"Habibi","year":"1989","journal-title":"Biol Reprod"},{"key":"10.1016\/S0223-5234(97)89637-7_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0167-0115(92)90620-A","volume":"37","author":"Habibi","year":"1992","journal-title":"Regulatory Peptides"},{"key":"10.1016\/S0223-5234(97)89637-7_bib25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0003-2697(80)90515-1","volume":"107","author":"Munson","year":"1980","journal-title":"Anal Biochem"},{"key":"10.1016\/S0223-5234(97)89637-7_bib26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0165-6147(94)90049-3","volume":"15","author":"Moore","year":"1994","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/S0223-5234(97)89637-7_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1054-3589(08)60667-5","volume":"33","author":"Moore","year":"1995","journal-title":"Adv Pharmacol"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523497896377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523497896377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:37:27Z","timestamp":1759325847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523497896377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["S0223523497896377"],"URL":"https:\/\/doi.org\/10.1016\/s0223-5234(97)89637-7","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[1998,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure elucidation and conformational analysis of gonadotropin releasing hormone and its novel synthetic analogue [Tyr(OMe)5, d-Lys6, Aze9NHEtGnRH: The importance of aromatic clustering in the receptor binding activity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0223-5234(97)89637-7","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997 Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}