{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T06:12:22Z","timestamp":1775369542168,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[1998,9]]},"DOI":"10.1016\/s0301-2115(98)00086-4","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T12:16:11Z","timestamp":1027599371000},"page":"31-38","source":"Crossref","is-referenced-by-count":72,"title":["Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal"],"prefix":"10.1016","volume":"80","author":[{"given":"Dora","family":"Brites","sequence":"first","affiliation":[]},{"given":"Cec\u0131\u0301lia M.P","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Helena","family":"van-Zeller","sequence":"additional","affiliation":[]},{"family":"Alexandra Brito","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Silva","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0301-2115(98)00086-4_BIB1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0002-9378(79)90683-5","article-title":"Obstetric cholestasis \u2013 a 14-year review","volume":"133","author":"Johnston","year":"1979","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0020-7292(84)90019-5","article-title":"Maternal serum bile acid levels and fetal distress in cholestasis of pregnancy","volume":"22","author":"L\u00e4atikainen","year":"1984","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.1471-0528.1988.tb06791.x","article-title":"Fetal outcome in obstetric cholestasis","volume":"95","author":"Fisk","year":"1988","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0002-9378(78)90743-3","article-title":"Effect of cholestyramine and phenobarbital on pruritus and serum bile acid levels in cholestasis of pregnancy","volume":"132","author":"L\u00e4atikainen","year":"1978","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB5","first-page":"1084","article-title":"S-Adenosyl-l-methionine in the treatment of patients with intrahepatic cholestasis of pregnancy: a randomized, double-blind, placebo controlled study with negative results","volume":"13","author":"Ribalta","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0168-8278(05)80122-9","article-title":"Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy [Letter]","volume":"16","author":"Gonzalez","year":"1992","journal-title":"J Hepatol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1471-0528.1992.tb14465.x","article-title":"The treatment of intrahepatic cholestasis of pregnancy by dexamethasone","volume":"99","author":"Hirvioja","year":"1992","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB8","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/hep.1840150612","article-title":"Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy","volume":"15","author":"Palma","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB9","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/gut.37.4.580","article-title":"Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid","volume":"37","author":"Davies","year":"1995","journal-title":"Gut"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0301-2115(96)02442-6","article-title":"S-adenosylmethionine versus ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: preliminary results of a controlled trial","volume":"67","author":"Floreani","year":"1996","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0301-2115(97)00185-1","article-title":"Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration","volume":"76","author":"Brites","year":"1998","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0168-8278(98)80207-9","article-title":"Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy","volume":"28","author":"Brites","year":"1998","journal-title":"J Hepatol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB13","doi-asserted-by":"crossref","unstructured":"Serrano MA, Brites D, Larena MG, et al. Effect of ursodeoxycholic acid treatment during intrahepatic cholestasis of pregnancy on the kinetics of bile acid transport across the placenta. J Hepatol 1998 (in press).","DOI":"10.1016\/S0168-8278(98)80234-1"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0009-8981(83)90114-6","article-title":"Is normal pregnancy cholestatic?","volume":"130","author":"Fulton","year":"1983","journal-title":"Clin Chim Acta"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB15","doi-asserted-by":"crossref","first-page":"971","DOI":"10.5694\/j.1326-5377.1967.tb19875.x","article-title":"Pregnancy is cholestatic","volume":"25","author":"Simcock","year":"1967","journal-title":"Med J Aust"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB16","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0002-9378(16)32430-9","article-title":"A prospective study of 18 patients with cholestasis of pregnancy","volume":"142","author":"Shaw","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1471-0528.1981.tb00975.x","article-title":"Changes in serum bile acids concentrations during normal pregnancy, in patients with intrahepatic cholestasis of pregnancy and in pregnant women with itching","volume":"88","author":"Heikkinen","year":"1981","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB18","first-page":"581","article-title":"Serum bile acids in the early diagnosis of intrahepatic cholestasis of pregnancy","volume":"61","author":"Heikkinen","year":"1983","journal-title":"Obstet Gynecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/hep.1840020114","article-title":"The enigma of intrahepatic cholestasis of pregnancy: lessons from Chile","volume":"2","author":"Reyes","year":"1982","journal-title":"Hepatology"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0168-8278(95)80261-4","article-title":"Serum conjugated bile acids profile during intrahepatic cholestasis of pregnancy","volume":"22","author":"Bacq","year":"1995","journal-title":"J Hepatol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0009-8981(76)90007-3","article-title":"A simple and sensitive assay of bile acids","volume":"70","author":"Mashige","year":"1976","journal-title":"Clin Chim Acta"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB22","first-page":"8","article-title":"Doseamento enzim\u00e1tico dos \u00e1cidos biliares. Optimiza\u00e7\u00e3o da reac\u00e7\u00e3o e valores normais","volume":"36","author":"Brites","year":"1985","journal-title":"Rev Port Farm"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB23","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/clinchem\/29.9.1694a","article-title":"Evaluation of a sample preparation procedure for bile acids in serum and bile","volume":"29","author":"Feldmann","year":"1983","journal-title":"Clin Chem"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0378-4347(00)82785-1","article-title":"High-performance liquid chromatographic determination of tauro- and glyco-conjugated bile acids in human serum","volume":"490","author":"Labb\u00e9","year":"1989","journal-title":"J Chromatogr"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0009-8981(76)90023-1","article-title":"Separation of conjugated and unconjugated bile acids by thin layer chromatography","volume":"70","author":"Beke","year":"1976","journal-title":"Clin Chim Acta"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0378-4347(00)81678-3","article-title":"Thin-layer chromatographic method for the separation of conjugated deoxycholic acid from conjugated chenodeoxycholic acid","volume":"145","author":"Goswami","year":"1978","journal-title":"J Chromatogr"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB27","first-page":"30","article-title":"Separa\u00e7\u00e3o, identifica\u00e7\u00e3o e quantifica\u00e7\u00e3o dos diferentes \u00e1cidos biliares no soro","volume":"36","author":"Correia","year":"1985","journal-title":"Rev Port Farm"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB28","first-page":"155","article-title":"Fetal prognosis in obstetric hepatosis","volume":"64","author":"Laatikainen","year":"1975","journal-title":"Ann Chir Gynecol Fenn"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB29","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0002-9378(75)90727-9","article-title":"Fetal bile acid levels in pregnancies complicated by maternal intrahepatic cholestasis","volume":"122","author":"L\u00e4atikainen","year":"1975","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB30","first-page":"A163","article-title":"Correction of fetal cord serum bile acid profile by maternal ursodeoxycholic acid therapy in cholestasis of pregnancy","volume":"26","author":"Brites","year":"1997","journal-title":"J Hepatol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB31","first-page":"A164","article-title":"Amniotic fluid bile acid changes in the course of ursodeoxycholic acid therapy in intrahepatic cholestasis of pregnancy","volume":"26","author":"Brites","year":"1997","journal-title":"J Hepatol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB32","unstructured":"Reyes H. Ursodeoxycholic acid in the treatment of cholestasis of pregnancy. In: Paumgartner G, Stiehl A, Gerok W, editors. Bile acids in hepatobiliary diseases. Freiburg: Falk Foundation, 1996:68\u201369."},{"key":"10.1016\/S0301-2115(98)00086-4_BIB33","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1002\/hep.510260627","article-title":"Progesterone metabolites and bile acids in serum of patients with intrahepatic cholestasis of pregnancy: effect of ursodeoxycholic acid therapy","volume":"26","author":"Meng","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB34","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0168-8278(97)80147-X","article-title":"Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy","volume":"27","author":"Meng","year":"1997","journal-title":"J Hepatol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB35","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0168-8278(97)80146-8","article-title":"Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo","volume":"27","author":"Palma","year":"1997","journal-title":"J Hepatol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB36","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0002-9378(96)80031-7","article-title":"Intrahepatic cholestasis of pregnancy: perinatal outcome associated with expectant management","volume":"175","author":"Alsulyman","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB37","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0009-8981(93)90117-M","article-title":"Biological variability of twenty-five serum analytes during normal pregnancy [Letter]","volume":"214","author":"Alberty","year":"1993","journal-title":"Clin Chim Acta"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB38","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/hep.510230514","article-title":"Liver function tests in normal pregnancy: a prospective study of 103 pregnant women and 103 matched controls","volume":"23","author":"Bacq","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB39","unstructured":"Reyes H. The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy. In: Riely CA, Abell TL, editors. Gastroenterology Clinics of North America. Gastrointestinal and liver problems in pregnancy. Philadelphia: WB Saunders, 1992:905\u2013921."},{"key":"10.1016\/S0301-2115(98)00086-4_BIB40","first-page":"1480","article-title":"Ict\u00e8re sous contraceptif oral, cholestase gravidique et \u00e9l\u00e9vation des transaminases","volume":"18","author":"Ancey","year":"1989","journal-title":"Presse Med"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/BF01296169","article-title":"Intrahepatic cholestasis of pregnancy with marked elevation of transaminases in a black american","volume":"32","author":"Wilson","year":"1987","journal-title":"Dig Dis Sci"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB42","first-page":"161","article-title":"Cholestase gravidique. Une forme cytolytic pure","volume":"26","author":"Bondu","year":"1997","journal-title":"Press Med"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB43","first-page":"768","article-title":"Cholestase gravidique et activit\u00e9 s\u00e9rique normale de la gamma glutamyl transpeptidase [Letter]","volume":"12","author":"Jacquemin","year":"1988","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB44","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0016-5085(86)90682-7","article-title":"Serum bile acid concentrations during pregnancy and their relationship to obstetric cholestasis","volume":"91","author":"Lunzer","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB45","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1471-0528.1991.tb10367.x","article-title":"Serum bile acids in normal pregnancy","volume":"98","author":"Carter","year":"1991","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3109\/00016348009155420","article-title":"Radioimmunoassay of serum bile acids in normal pregnancy and in recurrent cholestasis of pregnancy","volume":"59","author":"Samuelson","year":"1980","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB47","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/01443618309071218","article-title":"Bile acids in maternal serum, umbilical cord serum and amniotic fluid of healthy women, women with pruritus and patients with intrahepatic cholestasis of pregnancy","volume":"4","author":"Heikkinen","year":"1983","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB48","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0009-8981(66)90294-4","article-title":"Serum bile acids levels in pregnancy with pruritus (bile acids and steroids 158)","volume":"13","author":"Sj\u00f6vall","year":"1966","journal-title":"Clin Chim Acta"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0009-8981(75)90145-X","article-title":"Determination of serum bile acids by glass capillary gas-liquid chromatography","volume":"64","author":"L\u00e4atikainen","year":"1975","journal-title":"Clin Chim Acta"},{"key":"10.1016\/S0301-2115(98)00086-4_BIB50","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0009-8981(78)90233-4","article-title":"Biliary bile acids in uncomplicated pregnancy and in cholestasis of pregnancy","volume":"85","author":"L\u00e4atikainen","year":"1978","journal-title":"Clin Chim Acta"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211598000864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211598000864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T16:23:21Z","timestamp":1620231801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211598000864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["S0301211598000864"],"URL":"https:\/\/doi.org\/10.1016\/s0301-2115(98)00086-4","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}