{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:37:56Z","timestamp":1770064676403,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Pharmaceutics"],"published-print":{"date-parts":[[1997,4]]},"DOI":"10.1016\/s0378-5173(97)04885-0","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T14:36:35Z","timestamp":1027607795000},"page":"255-265","source":"Crossref","is-referenced-by-count":143,"title":["Peptide-loaded solid lipid nanoparticles (SLN): Influence of production parameters"],"prefix":"10.1016","volume":"149","author":[{"given":"Ant\u00f3nio J.","family":"Almeida","sequence":"first","affiliation":[]},{"given":"Stephan","family":"Runge","sequence":"additional","affiliation":[]},{"given":"Rainer H.","family":"M\u00fcller","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0378-5173(97)04885-0_BIB1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/252252a0","article-title":"Liposomes as Immunological adjuvants","volume":"252","author":"Allison","year":"1974","journal-title":"Nature"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB2","article-title":"Particulate Carriers as Immunological Adjuvants","author":"Almeida","year":"1993"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB3","doi-asserted-by":"crossref","first-page":"316S","DOI":"10.1042\/bst020316s","article-title":"Poly(lactic acid) microspheres as Immunological adjuvants for orally delivered cholera toxin B subunit","volume":"20","author":"Almeida","year":"1992","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0264-410X(94)90092-2","article-title":"Biodegradable microspheres as controlled-release tetanus toxoid delivery systems","volume":"12","author":"Alonso","year":"1994","journal-title":"Vaccine"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB5","first-page":"383","article-title":"Lipospheres as a vaccine carrier system: effects of size, charge, and phospholipid composition","volume":"1","author":"Amselem","year":"1992","journal-title":"Vaccine Res."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0264-410X(92)90437-O","article-title":"Incorporation of soluble antigens into ISCOMs: HW gpl20 ISCOMs induce virus neutralising antibodies","volume":"10","author":"Browning","year":"1992","journal-title":"Vaccine"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB7","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3109\/03639049209046331","article-title":"Formulation concerns of protein drugs","volume":"18","author":"Chen","year":"1992","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB8","first-page":"31","article-title":"Understanding how proteins fold: the lysozyme story so far","volume":"19","author":"Dobson","year":"1994","journal-title":"TIBS"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB9","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/jps.2600710523","article-title":"Acrylic microspheres in vivo. V. Immunological properties of immobilized asparaginase in microparticles","volume":"71","author":"Edman","year":"1982","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB10","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1128\/IAI.59.9.2978-2986.1991","article-title":"Biodegradable and biocompatible poly(d,l-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies","volume":"59","author":"Eldridge","year":"1991","journal-title":"Infect. Immun."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB11","first-page":"350","article-title":"Relationship between chemical structure and biological activity of hen egg white lysozyme and lysozymes of different species","volume":"167","author":"Joll\u00e8s","year":"1967"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0142-9612(84)90002-4","article-title":"Degradation of poly(isobutylcyanoacrylate) nanoparticles","volume":"5","author":"Lenaerts","year":"1984","journal-title":"Biomaterials"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0014-5793(75)80272-9","article-title":"Electrophoretic resolution of the \u2018major outer membrane protein\u2019 of Escherichia coli K12 into four bands","volume":"58","author":"Lugtenberg","year":"1975","journal-title":"FEBS Lett."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB14","first-page":"490","article-title":"Comparison of cytotoxicity between polyester nanoparticles and solid lipid nanoparticles","volume":"20","author":"Maa\u00dfen","year":"1993"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB15","first-page":"62","article-title":"Solid lipid nanoparticles (SLN)\u2014an alternative colloidal carrier system for controlled drug delivery","volume":"41","author":"M\u00fcller","year":"1995","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB16","series-title":"Microspheres and Drug Therapy. Pharmaceutical, Immunological and Medical Aspects","first-page":"39","article-title":"Physicochemical aspects of the behaviour of biological components at solid\/liquid interfaces","author":"Norde","year":"1984"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0166-6622(92)80164-W","article-title":"Structure of adsorbed and desorbed proteins","volume":"64","author":"Norde","year":"1992","journal-title":"Colloids Surfaces"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0264-410X(89)90231-4","article-title":"Poly(butyl-2-cyanoacrylate) particles as adjuvants for oral immunisation","volume":"7","author":"O'Hagan","year":"1989","journal-title":"Vaccine"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB19","first-page":"393","article-title":"Standards and reference materials","volume":"Vol. 11","author":"Portenhauser","year":"1983"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB20","first-page":"123","article-title":"Submicron-sized parenteral carrier systems based on lipids","volume":"1","author":"Sieckmann","year":"1992","journal-title":"Pharm. Pharmacol. Lett."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0927-7765(94)80063-4","article-title":"Thermoanalysis of the recrystallization process of melt-homogenized glyceride nanoparticles","volume":"3","author":"Sieckmann","year":"1994","journal-title":"Colloids Surfaces B: Biointerfaces"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB22","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1023\/A:1015832302605","article-title":"Controlled delivery of diphtheria toxoid using biodegradable poly(d,l-lactide) microparticles","volume":"8","author":"Singh","year":"1991","journal-title":"Pharm. Res."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of proteins using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal Biochem."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00002030-199104000-00012","article-title":"High antibody titres in mice with polymethylmethacrylate nanoparticles as adjuvant for HIV vaccines","volume":"5","author":"Stieneker","year":"1991","journal-title":"AIDS"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0006-3002(52)90045-0","article-title":"The measurement of lysozyme activity and the ultra-violet inactivation of lysozyme","volume":"8","author":"Sugar","year":"1952","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0378-5173(95)00057-P","article-title":"Production and characterization of a peptide containing w\/o emulsion","volume":"123","author":"Trenktrog","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/S0378-5173(97)04885-0_BIB27","article-title":"Feste Lipid Nanopartikel (SLN) f\u00fcr die Gewebsspezifische Arneistoffapplikation","author":"Weyhers","year":"1995"},{"key":"10.1016\/S0378-5173(97)04885-0_BIB28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0168-3659(92)90021-I","article-title":"Pulsatile release of lysozyme from ointment-like poly(ortho esters)","volume":"21","author":"W\u00fcthrich","year":"1992","journal-title":"J. Control. Release"}],"container-title":["International Journal of Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378517397048850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378517397048850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T16:48:16Z","timestamp":1579020496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378517397048850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["S0378517397048850"],"URL":"https:\/\/doi.org\/10.1016\/s0378-5173(97)04885-0","relation":{},"ISSN":["0378-5173"],"issn-type":[{"value":"0378-5173","type":"print"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}