{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:28:14Z","timestamp":1772893694750,"version":"3.50.1"},"reference-count":51,"publisher":"Informa UK Limited","issue":"3","license":[{"start":{"date-parts":[[2009,5,31]],"date-time":"2009-05-31T00:00:00Z","timestamp":1243728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Revista Portuguesa de Pneumologia"],"published-print":{"date-parts":[[2009,5,31]]},"DOI":"10.1016\/s0873-2159(15)30146-x","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T04:31:59Z","timestamp":1431145919000},"page":"461-472","source":"Crossref","is-referenced-by-count":2,"title":["A interven\u00e7\u00e3o da c\u00e9lula epitelial na asma"],"prefix":"10.1080","volume":"15","author":[{"given":"Anabela Mota","family":"Pinto","sequence":"first","affiliation":[{"name":"Professora Associada com Agrega\u00e7\u00e3o de Fisiopatologia \u2013 Faculdade de Medicina da Universidade de Coimbra Directora do Instituto de Patologia Geral"}]},{"given":"Ana","family":"Todo-Bom","sequence":"additional","affiliation":[{"name":"Assistente Hospitalar Graduada em Imunoalergologia nos Hospitais da Universidade de Coimbra. Doutoramento em Medicina Interna \u2013 Pneumologia pela Faculdade de Medicina da Universidade de Coimbra"}]}],"member":"301","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"issue":"5","key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1164\/ajrccm.161.5.9903102","article-title":"Asthma. From bronchoconstriction to airways inflammation and remodeling","volume":"161","author":"Jean Bousquet","year":"2000","unstructured":"Jean BousquetJeffery P.K.Busse W.W.Johnson M.Vignola A.M. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000; 161(5): 1720\u20131745.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"e_1_2_1_3_1","first-page":"43","article-title":"Fisiopatologia da asma grave","volume":"14","author":"Todo-Bom A.","year":"2006","unstructured":"Todo-Bom A.Mota Pinto A. Fisiopatologia da asma grave. Rev Port Imunoalergol 2006; 14(Supl 2): 43\u201348.","journal-title":"Rev Port Imunoalergol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.03.041"},{"key":"e_1_2_1_5_1","first-page":"1","article-title":"Regulation of FoxP3+ Regulatory T Cells and Th17 cells by retinoids","volume":"416910","author":"Kim Chang H.","year":"2008","unstructured":"Kim Chang H. Regulation of FoxP3+ Regulatory T Cells and Th17 cells by retinoids. Clin Dev Immunol 2008; 416910: 1\u201312.","journal-title":"Clin Dev Immunol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2434"},{"issue":"3","key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jaci.2008.05.048","article-title":"CD4 + CD25 + regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling","volume":"122","author":"Jennifer Kearley","year":"2008","unstructured":"Jennifer KearleyRobinson D.S.Lloyd C.M. CD4 + CD25 + regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol 2008; 122(3): 617\u2013624.","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200602-189OC"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2745.2002.01486.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01785.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2497"},{"key":"e_1_2_1_12_1","first-page":"193","article-title":"Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma","volume":"8","author":"Hamida Hammad","year":"2008","unstructured":"Hamida HammadLambrecht B.N. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nature Rev 2008; 8: 193\u2013204.","journal-title":"Nature Rev"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00958.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.05.029"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.02.007"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F304"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0109OC"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.5.2910"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.087"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0085com"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1135"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.04.007"},{"issue":"2","key":"e_1_2_1_23_1","first-page":"58","article-title":"Novel functions of two chemokines in allergic disease thymus and activation-regulated chemokine (TARC)\/CCL17 and macrophage-derived chemokine (MDC)\/CCL22","volume":"18","author":"Masafumi Arima","year":"2006","unstructured":"Masafumi ArimaFukuda T. Novel functions of two chemokines in allergic disease thymus and activation-regulated chemokine (TARC)\/CCL17 and macrophage-derived chemokine (MDC)\/CCL22. Allergy Clin Immunol Int \u2013 J World Allergy Org 2006; 18(2): 58\u201364.","journal-title":"Allergy Clin Immunol Int \u2013 J World Allergy Org"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.8183"},{"issue":"6","key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1027\/0838-1925.18.6.242","article-title":"Substance P in long-lasting asthma: Immunoinflammatory pathways","volume":"18","author":"Ana Todo-Bom","year":"2006","unstructured":"Ana Todo-BomMota Pinto A.Vale Pereira S.Alves V.Dourado M.Santos Rosa M. Substance P in long-lasting asthma: Immunoinflammatory pathways. Allergy Clin Immunol Int \u2013 J World Allergy Org 2006; 18(6): 242\u2013248.","journal-title":"Allergy Clin Immunol Int \u2013 J World Allergy Org"},{"issue":"1","key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.regpep.2004.07.017","article-title":"Inflammatory cells as source of tachykinin-induced mucus secretion in chronic bronchitis","volume":"124","author":"Jochen Springer","year":"2005","unstructured":"Jochen SpringerGroneberg D.A.Pregla R.Fischer A. Inflammatory cells as source of tachykinin-induced mucus secretion in chronic bronchitis. Regul Pept 2005; 124(1\u20133): 195\u2013201.","journal-title":"Regul Pept"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90066-6"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328013d61b"},{"key":"e_1_2_1_29_1","first-page":"283","article-title":"Processes involved in the repair of in-jured airway epithelia","volume":"51","author":"Tesfaigzi Y.","year":"2003","unstructured":"Tesfaigzi Y. Processes involved in the repair of in-jured airway epithelia. Arch Immunol Ther Exp (Warsz) 2003; 51: 283\u2013288.","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062211"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141718"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0702-605"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.030262"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.021"},{"key":"e_1_2_1_35_1","first-page":"395","article-title":"Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma","volume":"79","author":"Shaoli Zhang","year":"1999","unstructured":"Shaoli ZhangSmartt H.Holgate S.T.Roche W.R. Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma. Lab Invest 1999; 79: 395\u2013405.","journal-title":"Lab Invest"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2004-0193OC"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00163.2007"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-50"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.25.5.4298"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.062190"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200408-1003OC"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.1.407"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00070.2006"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712287105"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2079"},{"issue":"5","key":"e_1_2_1_46_1","doi-asserted-by":"crossref","first-page":"L847","DOI":"10.1152\/ajplung.00261.2006","article-title":"The \u201cwisdom\u201d of lung surfactant: balancing host defense and surface tension-reducing functions","volume":"291","author":"Jo Rae Wright","year":"2006","unstructured":"Jo Rae Wright. The \u201cwisdom\u201d of lung surfactant: balancing host defense and surface tension-reducing functions. Am J Physiol Lung Cell Mol Physiol 2006; 291(5): L847\u2013L850.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"e_1_2_1_47_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000102054","article-title":"Innate immunity: toll-like receptors and some more. a brief history, basic organization and relevance for the human newborn","volume":"92","author":"Andr\u00e9 Fleer","year":"2007","unstructured":"Andr\u00e9 FleerKrediet T.G. Innate immunity: toll-like receptors and some more. a brief history, basic organization and relevance for the human newborn. Neonatology 2007; 92(3): 145\u2013157.","journal-title":"Neonatology"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1086\/368163"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040342"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500599102"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200706-066TH"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00379.2006"}],"container-title":["Revista Portuguesa de Pneumologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S087321591530146X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S087321591530146X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1016\/S0873-2159%2815%2930146-X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T23:25:52Z","timestamp":1743204352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1016\/S0873-2159%2815%2930146-X"}},"subtitle":["The role of the epithelial cell in asthma"],"short-title":[],"issued":{"date-parts":[[2009,5,31]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,5,31]]}},"alternative-id":["10.1016\/S0873-2159(15)30146-X"],"URL":"https:\/\/doi.org\/10.1016\/s0873-2159(15)30146-x","relation":{},"ISSN":["0873-2159"],"issn-type":[{"value":"0873-2159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,31]]}}}