{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T23:40:30Z","timestamp":1743205230721,"version":"3.40.3"},"reference-count":58,"publisher":"Informa UK Limited","issue":"4","license":[{"start":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T00:00:00Z","timestamp":1248998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Revista Portuguesa de Pneumologia"],"published-print":{"date-parts":[[2009,7,31]]},"DOI":"10.1016\/s0873-2159(15)30164-1","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T04:31:32Z","timestamp":1431145892000},"page":"683-696","source":"Crossref","is-referenced-by-count":2,"title":["Os genes ERCC1 e RRM1 no carcinoma broncopulmonar"],"prefix":"10.1080","volume":"15","author":[{"given":"Lina","family":"Carvalho","sequence":"first","affiliation":[{"name":"Professora de Anatomia Patol\u00f3gica\/Oncologia Faculdade de Medicina, Universidade de Coimbra"}]},{"given":"Ant\u00f3nio","family":"Silva","sequence":"additional","affiliation":[{"name":"Disciplina de Oncologia, Anatomia Patol\u00f3gica\/Oncologia Faculdade de Medicina, Universidade de Coimbra"}]},{"given":"Cl\u00e1udia","family":"Andrade","sequence":"additional","affiliation":[{"name":"Disciplina de Oncologia, Anatomia Patol\u00f3gica\/Oncologia Faculdade de Medicina, Universidade de Coimbra"}]},{"given":"Cl\u00e1udia","family":"Barroso","sequence":"additional","affiliation":[{"name":"Disciplina de Oncologia, Anatomia Patol\u00f3gica\/Oncologia Faculdade de Medicina, Universidade de Coimbra"}]},{"given":"Cl\u00e1udia","family":"Farinha","sequence":"additional","affiliation":[{"name":"Disciplina de Oncologia, Anatomia Patol\u00f3gica\/Oncologia Faculdade de Medicina, Universidade de Coimbra"}]},{"given":"Jos\u00e9 Carlos","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Disciplina de Oncologia, Anatomia Patol\u00f3gica\/Oncologia Faculdade de Medicina, Universidade de Coimbra"}]},{"given":"Raquel","family":"Landeiro","sequence":"additional","affiliation":[{"name":"Disciplina de Oncologia, Anatomia Patol\u00f3gica\/Oncologia Faculdade de Medicina, Universidade de Coimbra"}]}],"member":"301","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-2-37"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035536"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206232"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22738"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70804-X"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043623"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2004.22.90140.7019"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.11.001"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.195"},{"key":"e_1_2_1_11_1","first-page":"17","article-title":"Polimorfismos e metila\u00e7\u00e3o de genes na selec\u00e7\u00e3o da terap\u00eautica do cancro do pulm\u00e3o","author":"Hespanhol V.P.","year":"2006","unstructured":"Hespanhol V.P. Polimorfismos e metila\u00e7\u00e3o de genes na selec\u00e7\u00e3o da terap\u00eautica do cancro do pulm\u00e3o. Revista GECP 2006: 17\u201321. 1\u20132.","journal-title":"Revista GECP"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32816b5c63"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.14.7835"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.9.1073"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.21.6559"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.14.8285"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(93)90164-D"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5416.958"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.05.006"},{"issue":"6","key":"e_1_2_1_20_1","first-page":"211","article-title":"Nucleotide excision repair","volume":"9","author":"Hoeilmakers J.H.","year":"1993","unstructured":"Hoeilmakers J.H. Nucleotide excision repair. II. From yeast to mammals. Trends Genet 1993; 9(6): 211\u2013217.","journal-title":"II. From yeast to mammals. Trends Genet"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.3.978"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060570"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00690-5"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.8.1527"},{"key":"e_1_2_1_25_1","article-title":"ERCC1 polymorphism is associated with differencial ERCC1 gene expression","volume":"1591","author":"Park D.J.","year":"2002","unstructured":"Park D.J.Stoehelmacher J.Zhang W., et al. ERCC1 polymorphism is associated with differencial ERCC1 gene expression. Proc Am Assoc Cancer 2002; 1591.","journal-title":"Proc Am Assoc Cancer"},{"key":"e_1_2_1_26_1","first-page":"555","article-title":"Comparison of two human ovarian carcinoma cell lines (A2780\/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene","volume":"16","author":"Yu J.J.","year":"2000","unstructured":"Yu J.J.Lee K.B.Mu C., et al. Comparison of two human ovarian carcinoma cell lines (A2780\/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene. Int J Oncol 2000; 16: 555\u2013560.","journal-title":"Int J Oncol"},{"key":"e_1_2_1_27_1","first-page":"162","article-title":"ERCC1 gene polymorphism as a predictor for clinical outcome in advenced colorectal cancer patients treated with platinum-based chemotherapy","volume":"1","author":"Park D.J.","year":"2003","unstructured":"Park D.J.Zhang W.Stoehlmaker J., et al. ERCC1 gene polymorphism as a predictor for clinical outcome in advenced colorectal cancer patients treated with platinum-based chemotherapy. Clin Adv Hematol Oncol 2003; 1: 162\u2013166.","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_1_28_1","first-page":"843","article-title":"Association of an ERCC1 polymorphism with adul-onset glioma","volume":"9","author":"Chen P.","year":"2000","unstructured":"Chen P.Wiencke J.Aldape K., et al. Association of an ERCC1 polymorphism with adul-onset glioma. Cancer Epidemiol Biomark Prev 2000; 9: 843\u2013847.","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.9.1084"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi232"},{"key":"e_1_2_1_31_1","first-page":"13","article-title":"A nucleotide polymorphism in ERCC1 in human ovarian cancer cells lines and tumor tissues","volume":"382","author":"Yu J.J.","year":"1997","unstructured":"Yu J.J.Mu C.Lee K.B., et al. A nucleotide polymorphism in ERCC1 in human ovarian cancer cells lines and tumor tissues. Mutat Res 1997; 382: 13\u201320.","journal-title":"Mutat Res"},{"key":"e_1_2_1_32_1","unstructured":"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6240"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3363"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.8.1527"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065411"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2004.07.043"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.12.002"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500259"},{"issue":"11","key":"e_1_2_1_39_1","first-page":"3","article-title":"Gemcitabine: Metabolism, mechanisms of action, and self potentiation","volume":"22","author":"Plunkett W.","year":"1995","unstructured":"Plunkett W.Huang P.Xu Y.Z., et al. Gemcitabine: Metabolism, mechanisms of action, and self potentiation. Semin Oncol 1995; 22(suppl 11): 3\u201310.","journal-title":"Semin Oncol"},{"issue":"20","key":"e_1_2_1_40_1","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-05-0989","article-title":"In vivo induction of resistance to gemcitabine resultas in increased expression of ribonucleotide reductase subunit M1 as the major determinant","volume":"65","author":"Bergman A.M.","year":"2005","unstructured":"Bergman A.M.Eijk P.P.van Haperen V.W.T.R.Smid K.Veerman G.Hubeek I.van den Ijssel P.Ylstra B.Peters G.J. In vivo induction of resistance to gemcitabine resultas in increased expression of ribonucleotide reductase subunit M1 as the major determinant. Cancer Res 2005; 65(20).","journal-title":"Cancer Res"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7010.899"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg059"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031644"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)01769-9"},{"issue":"4","key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMoa031644","article-title":"Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small cell lung cancer","volume":"350","author":"Arriagada R.","year":"2004","unstructured":"Arriagada R.Bergman B.Dunant A.Le Chevalier T.Pignon J.P.Vansteenkiste J. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small cell lung cancer. N Eng J Med 2004; 350(4): 351\u2013360.","journal-title":"N Eng J Med"},{"key":"e_1_2_1_46_1","first-page":"21","article-title":"Results of the randomized adjuvant lung cancer trials (IALT): Cisplatin-based chemotherapy (CT) vs. noCT in 1867 patients with resected non-small cell lung cancer (NSCLC)","author":"Le Chevalier T.","year":"2003","unstructured":"Le Chevalier T. Results of the randomized adjuvant lung cancer trials (IALT): Cisplatin-based chemotherapy (CT) vs. noCT in 1867 patients with resected non-small cell lung cancer (NSCLC). Proc ASCO 2003: 21.","journal-title":"Proc ASCO"},{"issue":"7","key":"e_1_2_1_47_1","first-page":"2286","article-title":"Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer","volume":"8","author":"Lord R.V.","year":"2002","unstructured":"Lord R.V.Branbender J.Gandara D.Alberola V.Camps C.Domine M., et al. Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer. Clin. Cancer Res 2002; 8(7): 2286\u20132291.","journal-title":"Clin. Cancer Res"},{"key":"e_1_2_1_48_1","first-page":"25","article-title":"Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non-smal cell lung cancer","author":"Simon G.R.","year":"2007","unstructured":"Simon G.R.Sharma A.Li X.Hazelton T.Walsh F.Williams C., et al. Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non-smal cell lung cancer. J Clin Oncol 2007: 25. in press.","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.1101"},{"issue":"2","key":"e_1_2_1_50_1","first-page":"S225","article-title":"Phase II study of sequential gemcitabine (G) and carboplatin (C) followed by docetaxel (D) as first-line chemotherapy for patients with advanced non-small cell lung cancer","volume":"41","author":"Chiappori A.","year":"2005","unstructured":"Chiappori A.Simon G.Rocha Lima C.Williams C.Haura E.Vaughn J., et al. Phase II study of sequential gemcitabine (G) and carboplatin (C) followed by docetaxel (D) as first-line chemotherapy for patients with advanced non-small cell lung cancer. Lung Cancer 2005; 41(2): S225.","journal-title":"Lung Cancer"},{"issue":"9","key":"e_1_2_1_51_1","article-title":"Customizing cisplatin based chemotherapy on quantitative excision repair cross-complementing 1 mRNA expression: a phase III randomized trial in non-small cell lung cancer. The 31st Congress of the European Society of Medical Oncology, 30 September \u2013 3 October 2006; Istanbul, Turkey","volume":"17","author":"Rosell R.","year":"2006","unstructured":"Rosell R.Gandara D.Cobo M., et al. Customizing cisplatin based chemotherapy on quantitative excision repair cross-complementing 1 mRNA expression: a phase III randomized trial in non-small cell lung cancer. The 31st Congress of the European Society of Medical Oncology, 30 September \u2013 3 October 2006; Istanbul, Turkey. Ann Oncol 2006; 17(suppl 9). abstract LBA 1.","journal-title":"Ann Oncol"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl300"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000204999.29924.da"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0247"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh319"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji427"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe068162"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.6.440"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068308"}],"container-title":["Revista Portuguesa de Pneumologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0873215915301641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0873215915301641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1016\/S0873-2159%2815%2930164-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T23:17:34Z","timestamp":1743203854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1016\/S0873-2159%2815%2930164-1"}},"subtitle":["ERCC1 and RRM1 genes in lung cancer"],"short-title":[],"issued":{"date-parts":[[2009,7,31]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,7,31]]}},"alternative-id":["10.1016\/S0873-2159(15)30164-1"],"URL":"https:\/\/doi.org\/10.1016\/s0873-2159(15)30164-1","relation":{},"ISSN":["0873-2159"],"issn-type":[{"type":"electronic","value":"0873-2159"}],"subject":[],"published":{"date-parts":[[2009,7,31]]}}}