{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T23:53:35Z","timestamp":1775692415644,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":3827,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1016\/s0925-4439(03)00018-8","type":"journal-article","created":{"date-parts":[[2003,3,14]],"date-time":"2003-03-14T13:29:05Z","timestamp":1047648545000},"page":"156-163","source":"Crossref","is-referenced-by-count":22,"title":["Sources of glucose production in cirrhosis by 2H2O ingestion and 2H NMR analysis of plasma glucose"],"prefix":"10.1016","volume":"1637","author":[{"given":"Rui","family":"Perdigoto","sequence":"first","affiliation":[]},{"given":"Alexandre L","family":"Furtado","sequence":"additional","affiliation":[]},{"given":"Armando","family":"Porto","sequence":"additional","affiliation":[]},{"given":"Tiago B","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Carlos F.G.C","family":"Geraldes","sequence":"additional","affiliation":[]},{"given":"John G","family":"Jones","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0925-4439(03)00018-8_BIB1","first-page":"E529","article-title":"Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis","volume":"276","author":"Petersen","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB2","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/S0016-5085(98)70033-2","article-title":"Quantification of gluconeogenesis in cirrhosis: response to glucagon","volume":"115","author":"Bugianesi","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/S0925-4439(03)00018-8_BIB3","first-page":"E1110","article-title":"Glycerol production and utilization in humans: sites and quantitation","volume":"271","author":"Landau","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1172\/JCI117635","article-title":"Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state","volume":"95","author":"Landau","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB5","first-page":"E1209","article-title":"Quantifying gluconeogenesis during fasting","volume":"273","author":"Chandramouli","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB6","first-page":"E23","article-title":"Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus","volume":"280","author":"Boden","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB7","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1104\/pp.118.4.1439","article-title":"Export of carbon from chloroplasts at night","volume":"118","author":"Schleucher","year":"1998","journal-title":"Plant Physiol."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1046\/j.1365-3040.1999.00440.x","article-title":"Intramolecular deuterium distributions reveal disequilibrium of chloroplast phosphoglucose isomerase","volume":"22","author":"Schleucher","year":"1999","journal-title":"Plant Cell Environ."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB9","first-page":"E848","article-title":"An integrated 2H and 13C NMR study of gluconeogenesis and TCA cycle flux in humans","volume":"281","author":"Jones","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1172\/JCI110240","article-title":"Hepatic, gut and renal substrate flux rates in patients with hepatic cirrhosis","volume":"68","author":"Owen","year":"1981","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB11","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1021\/ja01155a563","article-title":"Preparation of 1-C14-d-xylose from 1-C14-d-glucose","volume":"73","author":"Snowden","year":"1951","journal-title":"JACS"},{"key":"10.1016\/S0925-4439(03)00018-8_BIB12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/mrm.10234","article-title":"Quantitation of absolute 2H enrichment of plasma glucose by 2H NMR analysis of its monoacetone derivative","volume":"48","author":"Jones","year":"2002","journal-title":"MRM"},{"key":"10.1016\/S0925-4439(03)00018-8_BIB13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/1522-2594(200101)45:1<156::AID-MRM1020>3.0.CO;2-Z","article-title":"Quantifying tracer levels of 2H2O enrichment from microliter amounts of plasma and urine by 2H NMR","volume":"45","author":"Jones","year":"2001","journal-title":"MRM"},{"key":"10.1016\/S0925-4439(03)00018-8_BIB14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1172\/JCI118803","article-title":"Contributions of gluconeogenesis to glucose production in the fasted state","volume":"98","author":"Landau","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB15","first-page":"E717","article-title":"Origins of the hydrogen bound to carbon 1 of glucose in fasting: significance in gluconeogenesis quantitation","volume":"277","author":"Chandramouli","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/bj1920065","article-title":"The use of tritiated water to measure absolute rates of hepatic glycogen synthesis","volume":"192","author":"Postle","year":"1980","journal-title":"Biochem. J."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1432-1033.1974.tb03703.x","article-title":"Glucose synthesis in tritiated water","volume":"47","author":"Rognstad","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0003-2697(92)90238-3","article-title":"Quantitation of positional isomers of deuterium-labeled glucose by gas chromatography\/mass spectrometry","volume":"204","author":"Guo","year":"1992","journal-title":"Anal. Biochem."},{"key":"10.1016\/S0925-4439(03)00018-8_BIB19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0006-3002(60)90765-4","article-title":"Stereospecificity of the sugar-phosphate isomerase reactions\u2014a uniformity","volume":"42","author":"Rose","year":"1960","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0925-4439(03)00018-8_BIB20","first-page":"876","article-title":"Analysis of 2H enrichment in all positions of plasma glucose by 2H NMR spectroscopy following infusion of 2H2O","volume":"8","author":"Jones","year":"2000","journal-title":"ISMRM"},{"key":"10.1016\/S0925-4439(03)00018-8_BIB21","doi-asserted-by":"crossref","first-page":"21715","DOI":"10.1074\/jbc.270.37.21715","article-title":"Gluconeogenesis and glucuronidation in liver in vivo and the heterogeneity of hepatocyte function","volume":"270","author":"Ekberg","year":"1995","journal-title":"J. Biol. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443903000188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443903000188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T06:55:24Z","timestamp":1553669724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443903000188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["S0925443903000188"],"URL":"https:\/\/doi.org\/10.1016\/s0925-4439(03)00018-8","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}