{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:03:49Z","timestamp":1770822229418,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[1997,2]]},"DOI":"10.1016\/s0959-8049(96)00457-1","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T12:16:11Z","timestamp":1027599371000},"page":"293-296","source":"Crossref","is-referenced-by-count":28,"title":["Benign and malignant thyroid lesions show instability at microsatellite loci"],"prefix":"10.1016","volume":"33","author":[{"given":"P.","family":"Soares","sequence":"first","affiliation":[]},{"given":"N.R.","family":"Dos Santos","sequence":"additional","affiliation":[]},{"given":"R.","family":"Seruca","sequence":"additional","affiliation":[]},{"given":"R.A.","family":"Lothe","sequence":"additional","affiliation":[]},{"given":"M.","family":"Sobrinho-sim\u00f5es","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0959-8049(96)00457-1_BIB1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.8484121","article-title":"Clues to the pathogenesis of familial colorectal cancer","volume":"260","author":"Aaltonen","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/363558a0","article-title":"Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis","volume":"363","author":"Ionov","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB3","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.8484122","article-title":"Microsatellite instability in cancer of the proximal colon","volume":"260","author":"Thibodeau","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/0092-8674(93)90546-3","article-title":"The human mutator gene homolog MSH2 and its association with hereditary non-polyposis colon cancer","volume":"75","author":"Fishel","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB5","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/0092-8674(93)90330-S","article-title":"Mutation of a mutS homolog in hereditary nonpolyposis colorectal cancer","volume":"75","author":"Leach","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/368258a0","article-title":"Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer","volume":"368","author":"Bronner","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB7","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1126\/science.8128251","article-title":"Mutation of a mutL homolog in hereditary colon cancer","volume":"263","author":"Papadopoulos","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/371075a0","article-title":"Mutations of two PMS homologues in hereditary nonpolyposis colon cancer","volume":"371","author":"Nicolaides","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB9","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/0092-8674(93)90331-J","article-title":"Hypermutability and mismatch repair deficiency in RER+ tumour cells","volume":"75","author":"Parsons","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB10","doi-asserted-by":"crossref","first-page":"14367","DOI":"10.1016\/S0021-9258(17)36630-9","article-title":"Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability","volume":"269","author":"Umar","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1053\/gast.1996.v110.pm8536886","article-title":"Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis","volume":"110","author":"Dos Santos","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB12","first-page":"5087","article-title":"Genetic instability in pancreatic cancer and a poorly differentiated type of gastric cancer","volume":"53","author":"Han","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB13","first-page":"5849","article-title":"Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history","volume":"53","author":"Lothe","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB14","first-page":"5853","article-title":"Microsatellite instability is associated with tumours that characterize the hereditary non-polyposis colorectal carcinoma syndrome","volume":"53","author":"Peltom\u00e4ki","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB15","first-page":"5100","article-title":"Genetic instability microsatellites in endometrial carcinoma","volume":"53","author":"Risinger","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ijc.2910640108","article-title":"Sporadic gastric carcinomas with microsatellite instability display a particular clinico-pathologic profile","volume":"64","author":"Seruca","year":"1995","journal-title":"Int J Cancer"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB17","first-page":"2501","article-title":"Frequent micro-satellite instability in epithelial borderline ovarian tumours","volume":"56","author":"Tangir","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB18","first-page":"2999","article-title":"High frequency of mutator phenotype in human prostatic adenocarcinoma","volume":"9","author":"Gao","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB19","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/bjc.1995.374","article-title":"Microsatellite instability in human prostate cancers","volume":"72","author":"Watanabe","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ng0294-152","article-title":"Instability of short tandem repeats (microsatellites) in human cancers","volume":"6","author":"Wooster","year":"1994","journal-title":"Nature Genet"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB21","first-page":"3976","article-title":"Comparative allelotype of in situ and invasive human breast cancer: high frequency of microsatellite instability in lobular breast carcinomas","volume":"55","author":"Aldaz","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB22","first-page":"28","article-title":"Microsatellite instability and other molecular abnormalities in non-small cell lung cancer","volume":"55","author":"Fong","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB23","first-page":"3379","article-title":"Microsatellite instability occurs frequently and in both diploid and aneuploid cell population of Barren's associated esophageal adenocarcinoma","volume":"54","author":"Meltzer","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB24","first-page":"29","article-title":"Microsatellite instability occurs frequently in human gastric carcinoma","volume":"9","author":"Rhyu","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB25","first-page":"4841","article-title":"Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancer","volume":"54","author":"Suzuki","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB26","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/gcc.2870140305","article-title":"Deletion of 1p loci and microsatellite instability in colorectal polyps","volume":"14","author":"Lothe","year":"1995","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/ng0394-273","article-title":"Genomic instability in repeated sequences is an early somatic event in colorectal tumourigenesis that persists after transformation","volume":"6","author":"Shibata","year":"1994","journal-title":"Nature Genet"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB28","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0959-8049(94)00427-7","article-title":"Absence of microsatellite instability in thyroid carcinomas","volume":"31","author":"Vermiglio","year":"1995","journal-title":"Eur J Cancer"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB29","first-page":"3373","article-title":"Frequent replication errors at microsatellite loci in tumours of patients with multiple primary cancers","volume":"54","author":"Horii","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB30","first-page":"391","article-title":"An efficient salt-chloroform extraction of DNA from blood and tissues","volume":"5","author":"Mullenbach","year":"1989","journal-title":"Trends Genet"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB31","series-title":"World Health Organization\u2014International Histologic Classification of Tumours","year":"1988"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB32","article-title":"Tumours of the thyroid gland","author":"Rosai","year":"1992"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0165-7992(91)90108-G","article-title":"Constant denaturant gel electrophoresis, a modification of denaturing gel electrophoresis, in mutation detection","volume":"262","author":"Hovig","year":"1991","journal-title":"Mutat Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB34","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1093\/hmg\/4.11.2065","article-title":"Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas","volume":"4","author":"B\u00f8rresen","year":"1995","journal-title":"Human Mol Genet"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB35","first-page":"1237","article-title":"Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis","volume":"56","author":"Brentnall","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB36","first-page":"6189","article-title":"Genomic alterations and instabilities in renal cell carcinomas and their relationship to tumor pathology","volume":"55","author":"Thrash-Bingham","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB37","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/hmg\/2.8.1123","article-title":"Mutation of human short tandem repeats","volume":"2","author":"Weber","year":"1993","journal-title":"Human Mol Genet"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB38","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/bjc.1995.205","article-title":"Microsatellite instability in squamous cell carcinoma of the head and neck","volume":"71","author":"Field","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB39","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/bjc.1995.387","article-title":"Microsatellite instability in human testicular germ cell tumours","volume":"72","author":"Huddan","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB40","first-page":"3075","article-title":"Mutator phenotype may be required for multistage carcinogenesis","volume":"51","author":"Loeb","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1210\/jc.79.1.134","article-title":"Polyclonal and monoclonal thyroid nodules coexist within human multinodular goitres","volume":"79","author":"Kopp","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB42","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/365274a0","article-title":"Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair","volume":"365","author":"Strand","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB43","first-page":"6319","article-title":"Mutator phenotypes in human colorectal carcinoma cell lines","volume":"91","author":"Bhattacharyya","year":"1994"},{"key":"10.1016\/S0959-8049(96)00457-1_BIB44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/ng0195-48","article-title":"Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability","volume":"9","author":"Liu","year":"1995","journal-title":"Nature Genet"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804996004571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804996004571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T15:58:04Z","timestamp":1620230284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804996004571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["S0959804996004571"],"URL":"https:\/\/doi.org\/10.1016\/s0959-8049(96)00457-1","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}