{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:23:04Z","timestamp":1778563384905,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Cell Biology"],"published-print":{"date-parts":[[2002,11]]},"DOI":"10.1016\/s0962-8924(02)02387-5","type":"journal-article","created":{"date-parts":[[2002,12,2]],"date-time":"2002-12-02T17:06:32Z","timestamp":1038848792000},"page":"491-495","source":"Crossref","is-referenced-by-count":61,"title":["Macromolecular mobility inside the cell nucleus"],"prefix":"10.1016","volume":"12","author":[{"given":"Maria","family":"Carmo-Fonseca","sequence":"first","affiliation":[]},{"given":"Melpomeni","family":"Platani","sequence":"additional","affiliation":[]},{"given":"Jason R.","family":"Swedlow","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0962-8924(02)02387-5_BIB1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/35066075","article-title":"Chromosome territories, nuclear architecture and gene regulation in mammalian cells","volume":"2","author":"Cremer","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB2","doi-asserted-by":"crossref","first-page":"E53","DOI":"10.1038\/ncb0302-e53","article-title":"Nuclear organization and silencing: putting things in their place","volume":"4","author":"Hediger","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.280.5363.547","article-title":"Structure and function in the nucleus","volume":"280","author":"Lamond","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0962-8924(99)01606-2","article-title":"Nuclear bodies: multifaceted subdomains of the interchromatin space","volume":"9","author":"Matera","year":"1999","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB5","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1091\/mbc.11.3.799","article-title":"Half a century of \u2018The Nuclear Matrix\u2019","volume":"11","author":"Pederson","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0968-0004(01)02003-5","article-title":"Solute and macromolecule diffusion in cellular aqueous compartments","volume":"27","author":"Verkman","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB7","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1074\/jbc.275.3.1625","article-title":"Size-dependent DNA mobility in cytoplasm and nucleus","volume":"275","author":"Lukacs","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1083\/jcb.138.1.131","article-title":"Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus","volume":"138","author":"Seksek","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.291.5505.843","article-title":"Protein dynamics: implications for nuclear architecture and gene expression","volume":"291","author":"Misteli","year":"2001","journal-title":"Science"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0092-8674(00)81666-9","article-title":"Transport of proteins and RNAs in and out of the nucleus","volume":"99","author":"Nakielny","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0092-8674(01)00202-1","article-title":"Quality control of mRNA function","volume":"104","author":"Maquat","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB12","first-page":"125","article-title":"The structural basis of nuclear function","volume":"162A","author":"Jackson","year":"1995","journal-title":"Int. Rev. Cytol"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0960-9822(99)80136-5","article-title":"Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells","volume":"9","author":"Politz","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/excr.1999.4490","article-title":"The intranuclear movement of Balbiani ring pre-messenger ribonucleoprotein particles","volume":"251","author":"Singh","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB15","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1093\/emboj\/18.10.2855","article-title":"Inefficient processing impairs release of RNA from the site of transcription","volume":"18","author":"Cust\u00f3dio","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1083\/jcb.150.3.417","article-title":"Tracking COL1A1 RNA in osteogenesis imperfecta: splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain","volume":"150","author":"Johnson","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB17","doi-asserted-by":"crossref","unstructured":"Calapez, A. et al. The intranuclear mobility of messenger RNA binding proteins is ATP-dependent and temperature-sensitive, J. Cell Biol. (in press)","DOI":"10.1083\/jcb.200203046"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.cellbio.16.1.273","article-title":"Cajal bodies: the first 100 years","volume":"16","author":"Gall","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB19","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1093\/emboj\/21.11.2746","article-title":"Cajal body-specific small nuclear RNAs: a novel class of 2\u2032-O-methylation and pseudouridylation guide RNAs","volume":"21","author":"Darzacq","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB20","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1093\/emboj\/21.11.2736","article-title":"Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments","volume":"21","author":"Verheggen","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB21","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1091\/mbc.10.7.2297","article-title":"The movement of coiled bodies visualized in living plant cells by the green fluorescent protein","volume":"10","author":"Boudonck","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB22","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1083\/jcb.151.7.1561","article-title":"In vivo analysis of Cajal body movement, separation, and joining in live human cells","volume":"151","author":"Platani","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB23","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/ncb809","article-title":"Cajal Body dynamics and association with chromatin are ATP-dependent","volume":"4","author":"Platani","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB24","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/S0006-3495(97)78820-9","article-title":"Single-particle tracking: the distribution of diffusion coefficients","volume":"72","author":"Saxton","year":"1997","journal-title":"Biophys J."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1006\/jmbi.2000.3692","article-title":"Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy","volume":"298","author":"Wachsmuth","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB26","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1242\/jcs.114.16.2891","article-title":"Nuclear bodies","volume":"114","author":"Spector","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ncb740","article-title":"Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus","volume":"4","author":"Muratani","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0962-8924(97)01211-7","article-title":"In vivo visualization of chromosomes using lac operator\u2013repressor binding","volume":"8","author":"Belmont","year":"1998","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB29","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1126\/science.1388286","article-title":"Estimating genomic distance from DNA sequence location in cell nuclei by a random walk model","volume":"4","author":"van den Engh","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB30","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0960-9822(06)00412-X","article-title":"Interphase chromosomes undergo constrained diffusional motion in living cells","volume":"7","author":"Marshall","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB31","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/S0006-3495(99)77119-5","article-title":"Quantitative motion analysis of subchromosomal foci in living cells using four-dimensional microscopy","volume":"77","author":"Bornfleth","year":"1999","journal-title":"Biophys. J."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB32","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0960-9822(01)00390-6","article-title":"Multiple regimes of constrained chromosome motion are regulated in the interphase Drosophila nucleus","volume":"11","author":"Vazquez","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB33","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1126\/science.1065366","article-title":"Chromosome dynamics in the yeast interphase nucleus","volume":"294","author":"Heun","year":"2001","journal-title":"Science"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB34","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1126\/science.1067703","article-title":"Visualizing chromatin dynamics in interphase nuclei","volume":"296","author":"Gasser","year":"2002","journal-title":"Science"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB35","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1091\/mbc.7.5.825","article-title":"Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster","volume":"7","author":"Marshall","year":"1996","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB36","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1091\/mbc.12.11.3563","article-title":"Chromosomal G-dark bands determine the spatial organization of centromeric heterochromatin in the nucleus","volume":"12","author":"Carvalho","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0962-8924(02)02387-5_BIB37","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1083\/jcb.200111071","article-title":"Spatial organization of active and inactive genes and noncoding DNA within chromosome territories","volume":"157","author":"Mahy","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB38","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0960-9822(02)00695-4","article-title":"Chromatin motion is constrained by association with nuclear compartments in human cells","volume":"12","author":"Chubb","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB39","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/35055033","article-title":"Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator","volume":"3","author":"Tumbar","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0962-8924(02)02387-5_BIB40","doi-asserted-by":"crossref","first-page":"S0002","DOI":"10.1186\/gb-2001-2-3-reviews0002","article-title":"Nuclear dynamics: where genes are and how they got there","volume":"2","author":"Swedlow","year":"2001","journal-title":"Genome Biol."}],"container-title":["Trends in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892402023875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892402023875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T16:38:50Z","timestamp":1622479130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0962892402023875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["S0962892402023875"],"URL":"https:\/\/doi.org\/10.1016\/s0962-8924(02)02387-5","relation":{},"ISSN":["0962-8924"],"issn-type":[{"value":"0962-8924","type":"print"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}