{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:08:27Z","timestamp":1791990507182,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2004,6,5]],"date-time":"2004-06-05T00:00:00Z","timestamp":1086393600000},"content-version":"vor","delay-in-days":2804,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[1996,10]]},"DOI":"10.1016\/s0969-2126(96)00129-3","type":"journal-article","created":{"date-parts":[[2004,6,8]],"date-time":"2004-06-08T14:49:43Z","timestamp":1086706183000},"page":"1221-1229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":185,"title":["Metal-binding sites in the major groove of a large ribozyme domain"],"prefix":"10.1016","volume":"4","author":[{"given":"Jamie H","family":"Cate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Doudna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0969-2126(96)00129-3_BIB1","series-title":"Transfer RNA: Structure, Properties and Recognition, Monograph Series 9A","year":"1980"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1021\/bi00355a006","article-title":"Metal ion requirements and other aspects of the reaction catalyzed by M1 RNA, the RNA subunit of ribonuclease P from Escherichia coli","volume":"25","author":"Guerrier-Takada","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB3","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.1021\/bi00443a017","article-title":"Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme","volume":"28","author":"Grosshans","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1126\/science.2501870","article-title":"Defining the inside and outside of a catalytic RNA molecule","volume":"245","author":"Latham","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/361085a0","article-title":"Metal ion catalysis in the Tetrahymena ribozyme reaction","volume":"361","author":"Piccirilli","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1126\/science.7688142","article-title":"Ribozymes: a distinct class of metalloenzymes","volume":"261","author":"Pyle","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1126\/science.1989074","article-title":"Visualizing the higher order folding of a catalytic RNA molecule","volume":"251","author":"Celander","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB8","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1021\/bi00071a003","article-title":"An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme","volume":"32","author":"Murphy","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0022-2836(90)90386-Z","article-title":"Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis","volume":"216","author":"Michel","year":"1990","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB10","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1126\/science.8052848","article-title":"Kinetic intermediates in RNA folding","volume":"265","author":"Zarrinkar","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB11","first-page":"36","article-title":"Self-assembly of a group I intron active site from its component tertiary structural domains","volume":"1","author":"Doudna","year":"1995","journal-title":"RNA"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB12","first-page":"in press","article-title":"Crystal structure of a group I ribozyme domain: principles of RNA packing","author":"Cate","year":"1996","journal-title":"Science,"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB13","first-page":"in press","article-title":"RNA tertiary structure mediation by adenosine platforms","author":"Cate","year":"1996","journal-title":"Science,"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0022-2836(79)90268-7","article-title":"Solvent-accessible surfaces of nucleic acids","volume":"132","author":"Alden","year":"1979","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/bi00454a006","article-title":"Electrical potential of transfer RNAs: Codon-anticodon recognition","volume":"29","author":"Sharp","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB16","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1126\/science.7690496","article-title":"Major groove accessibility of RNA","volume":"261","author":"Weeks","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB17","first-page":"807","article-title":"G\u2013U base pairing motifs in ribosomal RNA","volume":"1","author":"Gautheret","year":"1996","journal-title":"RNA"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB18","series-title":"Proc. Nat. Acad. Sci vol 90","first-page":"7829","article-title":"Crystallization of ribozymes and small RNA motifs by a sparse matrix approach","author":"Doudna","year":"1993"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB19","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1021\/ic00314a026","article-title":"Syntheses of pentaammineosmium (III) and -osmium(II) complexes: Pentaammine(trifluoromethanesulfonato-O)osmium(III)","volume":"28","author":"Lay","year":"1989","journal-title":"Inorg. Chem"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1126\/science.179.4070.285","article-title":"Three-dimensional structure of yeast phenylalanine transfer RNA: folding of the polynucleotide chain","volume":"179","author":"Kim","year":"1973","journal-title":"Science"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/250546a0","article-title":"Structure of yeast phenylalanine tRNA at 3 \u00e5 resolution","volume":"250","author":"Robertus","year":"1974","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/372068a0","article-title":"Three-dimensional structure of a hammerhead ribozyme","volume":"372","author":"Pley","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0022-2836(77)80054-5","article-title":"A crystallographic study of metal-binding to yeast phenylalanine transfer RNA","volume":"111","author":"Jack","year":"1977","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0022-2836(85)90048-8","article-title":"Crystallographic refinement of yeast aspartic acid transfer RNA","volume":"184","author":"Westhof","year":"1985","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB25","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1002\/j.1460-2075.1989.tb08503.x","article-title":"A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing","volume":"8","author":"Flor","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/jmbi.1994.1117","article-title":"GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain","volume":"236","author":"Murphy","year":"1994","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB27","first-page":"78","article-title":"Stabilization of the tertiary structure of yeast phenylalanine tRNA by cobalt hexammine","volume":"697","author":"Hingerty","year":"1982","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB28","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/jmbi.1996.0090","article-title":"The high resolution crystal structure of the DNA decamer d(AGGCATGCCT)","volume":"256","author":"Nunn","year":"1996","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1021\/bi00323a001","article-title":"Structural basis for stabilization of Z-DNA by cobalt hexammine and magnesium cations","volume":"24","author":"Gessner","year":"1985","journal-title":"Biochemistry"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB30","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/07391102.1987.10507657","article-title":"The interactions of ruthenium hexammine with Z-DNA: Crystal structure of a ruthenium hexammine salt of d(CGCGCG) at 1.2 \u00e5 resolution","volume":"4","author":"Ho","year":"1987","journal-title":"J. Biomol. Struct. Dynam"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB31","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/333140a0","article-title":"A simple structural feature is a major determinant of the identity of a transfer RNA","volume":"333","author":"Hou","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB32","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1021\/bi00432a056","article-title":"A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA","volume":"28","author":"Park","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB33","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/300719a0","article-title":"Making ends meet: a model for RNA splicing in fungal mitochondria","volume":"300","author":"Davies","year":"1982","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/j.1460-2075.1983.tb01376.x","article-title":"Conservation of RNA secondary structure in two intron families including mitochondrial-, chloroplast-, and nuclear-encoded members","volume":"2","author":"Michel","year":"1983","journal-title":"EMBO J"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB35","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1021\/bi952244f","article-title":"Exocyclic amine of the conserved G\u2013U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5\u2032-splice site selection and transition state stabilization","volume":"35","author":"Strobel","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB36","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1006\/jmbi.1995.0381","article-title":"Solution structure of the P1 substrate duplex from Group I self-splicing introns","volume":"250","author":"Allain","year":"1995","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB37","doi-asserted-by":"crossref","first-page":"11124","DOI":"10.1021\/bi00110a015","article-title":"Nearest neighbor parameters for G\u2013U mismatches","volume":"30","author":"He","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB38","series-title":"Critical Stability Constants","author":"Martell","year":"1974"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB39","series-title":"Proceedings of the CCP4 Study Weekend: Data Collection and Processing","first-page":"56","article-title":"Oscillation Data Reduction Program","author":"Otwinowski","year":"1993"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB40","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","article-title":"The CCP4 suite programs for protein crystallography","volume":"50","year":"1994","journal-title":"Acta Cryst. D"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB41","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0076-6879(85)15009-3","article-title":"Resolution of phase ambiguity in macromolecular crystallography","volume":"115","author":"Wang","year":"1985","journal-title":"Meth. Enzymol"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1126\/science.1712983","article-title":"Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops","volume":"253","author":"Heus","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB43","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","article-title":"Improved methods for building protein models in electron density maps and the location of errors in these models","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Cryst. A"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB44","series-title":"X-PLOR. Version 3.1. A System for X-ray Crystallography and NMR","author":"Br\u00fcnger","year":"1993"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB45","doi-asserted-by":"crossref","first-page":"in press","DOI":"10.1107\/S0907444995011115","article-title":"New research for the refinement of nucleic acid containing structures","volume":"52","author":"Parkinson","year":"1996","journal-title":"Acta Cryst. D"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB46","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1021\/ja00477a004","article-title":"Extreme conformational flexibility of the furanose ring in DNA and RNA","volume":"100","author":"Levitt","year":"1978","journal-title":"J. Am. Chem. Soc"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB47","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1107\/S0108767392006044","article-title":"Model bias in macromolecular crystal structures","volume":"48","author":"Hodel","year":"1992","journal-title":"Acta Cryst. A"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB48","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1107\/S0108767386099622","article-title":"Improved Fourier coefficient for maps using phases from partial structures with errors","volume":"42","author":"Read","year":"1986","journal-title":"Acta Cryst. A"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB49","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1107\/S0365110X52002161","article-title":"Traitement statistique des erreurs dans la determination des structures cristallines","volume":"5","author":"Luzzati","year":"1952","journal-title":"Acta Cryst"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB50","series-title":"DelPhi, A Macromolecular Electrostatics Modelling Package","author":"Sharp","year":"1989"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB51","series-title":"RIBBONS 2.0 Manual","author":"Carson","year":"1991"},{"key":"10.1016\/S0969-2126(96)00129-3_BIB52","series-title":"GRASP: Graphical Representation and Analysis of Surface Properties","author":"Nicholls","year":"1993"}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212696001293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212696001293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T02:17:25Z","timestamp":1760840245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212696001293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["S0969212696001293"],"URL":"https:\/\/doi.org\/10.1016\/s0969-2126(96)00129-3","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[1996,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metal-binding sites in the major groove of a large ribozyme domain","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0969-2126(96)00129-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}