{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:51:47Z","timestamp":1761511907646},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":5335,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:p>The effect of lesioning the lateral portion of the caudal ventrolateral medullary reticular formation (VLMIat) on the noxious\u2010evoked expression of the <jats:italic>c\u2010fos<\/jats:italic> proto\u2010oncogene in spinal neurons, was studied in short\u2010term hypertensive rats. Occlusion of the renal artery for 96 h in unlesioned animals induced a 52% increase in blood pressure (BP) and a 66% decrease in the number of Fos\u2010immunoreactive (Fos\u2010IR) spinal cells following noxious cutaneous stimulation, as compared to values in normotensive controls. Lesioning the VLMIat in hypertensive rats by unilateral quinolinic acid (QA) injection (0.3 \u03bcl of a 180 nmol\/\u03bcl solution) 24 h before noxious stimulation, prevented the Fos\u2010IR cell decrease. In normotensive rats, lesioning the VLMIat produced no changes in <jats:italic>c\u2010fos<\/jats:italic> expression. To investigate the role played by the VLMIat in cardiovascular control, BP and heart rate (HR) were measured during local injections of QA or glutamate (0.5 \u03bcl of a 100 nmol\/\u03bcl solution) to normotensive animals. Injections of QA produced an immediate rise in BP and HR which reached maximal values (18 and 14% increase, respectively) 5 min after the administration onset, then returning gradually to baseline levels. Glutamate injections resulted in an immediate decrease of the same values, which reached 29 and 39%, respectively, 4 min after the beginning of injection, after which they decreased to baseline levels.<\/jats:p><jats:p>These results suggest that VLMIat neurons inhibit nociceptive spinal neurons in response to rises in blood pressure, while exerting negative control of cardiovascular parameters. It is suggested that the VLMIat is involved in the genesis of hypoalgesia during hypertension.<\/jats:p>","DOI":"10.1016\/s1090-3801(97)90073-2","type":"journal-article","created":{"date-parts":[[2004,2,21]],"date-time":"2004-02-21T10:23:03Z","timestamp":1077358983000},"page":"149-160","source":"Crossref","is-referenced-by-count":24,"title":["Lesions of the caudal ventrolateral medulla block the hypertension\u2010induced inhibition of noxious\u2010evoked <i>c\u2010fos<\/i> expression in the rat spinal 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