{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:31:01Z","timestamp":1759541461255},"reference-count":21,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes & Metabolism"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/s1262-3636(07)70287-2","type":"journal-article","created":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T22:22:25Z","timestamp":1173392545000},"page":"331-335","source":"Crossref","is-referenced-by-count":17,"title":["Modulation of the production of Reactive Oxygen Species (ROS) by cAMP-elevating agents in granulocytes from diabetic patients: an Akt\/PKB-dependent phenomenon"],"prefix":"10.1016","volume":"32","author":[{"given":"JA","family":"Nogueira-Machado","sequence":"first","affiliation":[]},{"given":"FC","family":"Lima e Silva","sequence":"additional","affiliation":[]},{"given":"EP","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"MR","family":"Calsolari","sequence":"additional","affiliation":[]},{"given":"DC","family":"Costa","sequence":"additional","affiliation":[]},{"given":"CS","family":"Perilo","sequence":"additional","affiliation":[]},{"given":"BC","family":"Horta","sequence":"additional","affiliation":[]},{"given":"IC","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"MM","family":"Chaves","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1262-3636(07)70287-2_bib1","first-page":"85","article-title":"High glucose-induced activation of protein kinase signaling pathway in vascular smooth muscle cells: a potential role in the pathogenesis of vascular dysfunction in diabetes","volume":"9","author":"Srivastrava","year":"2002","journal-title":"Int J Mol Med"},{"key":"10.1016\/S1262-3636(07)70287-2_bib2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0021-9258(17)42297-6","article-title":"The insulin signaling system","volume":"269","author":"White","year":"1994","journal-title":"J Biol Chem"},{"issue":"3pt1","key":"10.1016\/S1262-3636(07)70287-2_bib3","first-page":"E75","article-title":"Diverse signaling pathway in the cellular actions of insulin","volume":"270","author":"Saltiel","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/S1262-3636(07)70287-2_bib4","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2337\/diabetes.47.6.859","article-title":"Protein kinase C activation and the development of diabetic complications","volume":"47","author":"Koya","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/S1262-3636(07)70287-2_bib5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","article-title":"Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage","volume":"404","author":"Nishikawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S1262-3636(07)70287-2_bib6","first-page":"45","article-title":"Effect of cyclic nucleotides-elevating agents on nitric oxide production by human granulocytes from Type II diabetic patients","volume":"28","author":"Nogueira-Machado","year":"2002","journal-title":"Diabetes Metab"},{"key":"10.1016\/S1262-3636(07)70287-2_bib7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1262-3636(07)70068-X","article-title":"Modulation of the reactive oxygen species (ROS) generation mediated by cyclic AMP-elevating agents or interleukin 10 in granulocytes from type 2 diabetic patients (NIDDM): a PKA-independent phenomenon","volume":"29","author":"Nogueira-Machado","year":"2003","journal-title":"Diabetes Metab"},{"key":"10.1016\/S1262-3636(07)70287-2_bib8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0022-1759(81)90087-9","article-title":"A simple technique for simultaneous human leukocyte separation","volume":"40","author":"Bicalho","year":"1981","journal-title":"J Immunol Meth"},{"key":"10.1016\/S1262-3636(07)70287-2_bib9","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1053\/meta.2003.50093","article-title":"An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress","volume":"52","author":"Bonnefont-Rousselot","year":"2003","journal-title":"Metabolism"},{"key":"10.1016\/S1262-3636(07)70287-2_bib10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1023\/A:1022306328960","article-title":"Anti-oxidative effects of theophylline on human neutrophils involve cyclic nucleotides and protein kinase A","volume":"22","author":"Mahomed","year":"1998","journal-title":"Inflammation"},{"key":"10.1016\/S1262-3636(07)70287-2_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1097-2765(01)00432-4","article-title":"PKA phosphorylation of Src mediate cAMP's inhibition of cell growth via Rap 1","volume":"9","author":"Schmitt","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/S1262-3636(07)70287-2_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0898-6568(96)00052-6","article-title":"Protein kinase A down-regulates the phosphorylation of p47 phox in human neutrophils: a possible pathway for inhibition of the respiratory burst","volume":"8","author":"Bengis-Garber","year":"1996","journal-title":"Cell Signal"},{"key":"10.1016\/S1262-3636(07)70287-2_bib13","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1126\/science.1071550","article-title":"G protein pathway","volume":"796","author":"Neves","year":"2002","journal-title":"Science"},{"key":"10.1016\/S1262-3636(07)70287-2_bib14","first-page":"101","article-title":"The proto-oncogene OK\/Akt mediates the inhibition of glycogen synthase kinase-3K by insulin in skeletal muscle cell line L6","volume":"63","author":"Cros","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S1262-3636(07)70287-2_bib15","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/24884","article-title":"Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP","volume":"396","author":"De Rooij","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S1262-3636(07)70287-2_bib16","doi-asserted-by":"crossref","first-page":"11497","DOI":"10.1074\/jbc.M110856200","article-title":"Differential signaling of cyclic AMP: opposing effect of exchange protein directly activated by cyclic AMP and cAMP dependent protein kinase on protein kinase B activation","volume":"277","author":"Mei","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/S1262-3636(07)70287-2_bib17","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/ncb874","article-title":"A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK","volume":"160","author":"Enserink","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/S1262-3636(07)70287-2_bib18","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrm1197","article-title":"Epac: a new cAMP target and new avenues in cAMP research","volume":"4","author":"Bos","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.1016\/S1262-3636(07)70287-2_bib19","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1182\/blood-2003-06-2154","article-title":"Among circulating hemato-po\u00efetic cells, B-CLL uniquely express functional Epac1, but not Epac 1-mediated Rap1 activation does not account for PDE4 inhibitors-induced apoptosis","volume":"103","author":"Tiwari","year":"2004","journal-title":"Blood"},{"key":"10.1016\/S1262-3636(07)70287-2_bib20","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.cellsig.2004.11.010","article-title":"PKA-dependent and PKA-independent signals are involved in cAMP induced PRL expression in eosinophilic cell line Eol-1","volume":"17","author":"Gerlo","year":"2005","journal-title":"Cell Signal"},{"key":"10.1016\/S1262-3636(07)70287-2_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000063685","article-title":"Superoxide in the vascular system","volume":"39","author":"Wolin","year":"2002","journal-title":"J Vasc Res"}],"container-title":["Diabetes & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363607702872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363607702872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T21:45:33Z","timestamp":1628545533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1262363607702872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S1262363607702872"],"URL":"https:\/\/doi.org\/10.1016\/s1262-3636(07)70287-2","relation":{},"ISSN":["1262-3636"],"issn-type":[{"value":"1262-3636","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}