{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:38:06Z","timestamp":1775234286100,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Microbiology"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1016\/s1369-5274(03)00028-6","type":"journal-article","created":{"date-parts":[[2003,5,12]],"date-time":"2003-05-12T23:10:20Z","timestamp":1052781020000},"page":"191-197","source":"Crossref","is-referenced-by-count":585,"title":["LuxS quorum sensing: more than just a numbers game"],"prefix":"10.1016","volume":"6","author":[{"given":"Karina B","family":"Xavier","sequence":"first","affiliation":[]},{"given":"Bonnie L","family":"Bassler","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1369-5274(03)00028-6_BIB1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.micro.55.1.165","article-title":"Quorum sensing in bacteria","volume":"55","author":"Miller","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1126\/science.280.5361.295","article-title":"The involvement of cell-to-cell signals in the development of a bacterial biofilm","volume":"280","author":"Davies","year":"1998","journal-title":"Science"},{"key":"10.1016\/S1369-5274(03)00028-6_BIB3_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0092-8674(02)00829-2","article-title":"Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae","volume":"110","author":"Miller","year":"2002","journal-title":"Cell"},{"key":"10.1016\/S1369-5274(03)00028-6_BIB4_1","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1128\/AEM.68.8.3780-3789.2002","article-title":"Identification, characterization, and regulation of a cluster of genes involved in carbapenem biosynthesis in Photorhabdus luminescens","volume":"68","author":"Derzelle","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB5","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1073\/pnas.93.4.1549","article-title":"Cell\u2013cell communication regulates the effects of protein aspartate phosphatases on the phosphorelay controlling development in Bacillus subtilis","volume":"93","author":"Perego","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB6","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1128\/jb.179.12.4043-4045.1997","article-title":"Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi","volume":"179","author":"Bassler","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB7","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1073\/pnas.96.4.1639","article-title":"Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production","volume":"96","author":"Surette","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB8_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-2958.2001.02532.x","article-title":"The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule","volume":"41","author":"Schauder","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB9","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1101\/gad.899601","article-title":"The languages of bacteria","volume":"15","author":"Schauder","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB10_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/415545a","article-title":"Structural identification of a bacterial quorum-sensing signal containing boron","volume":"415","author":"Chen","year":"2002","journal-title":"Nature"},{"key":"10.1016\/S1369-5274(03)00028-6_BIB11","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1099\/00221287-148-4-909","article-title":"LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy 5-methyl 3(2H)-furanone","volume":"148","author":"Winzer","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/S1369-5274(03)00028-6_BIB12","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1365-2958.1993.tb01737.x","article-title":"Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence","volume":"9","author":"Bassler","year":"1993","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2958.1994.tb00422.x","article-title":"Multiple signalling systems controlling expression of luminescence in Vibrio harveyi: sequence and function of genes encoding a second sensory pathway","volume":"13","author":"Bassler","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB14_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1365-2958.2002.02863.x","article-title":"The luxS gene is involved in cell\u2013cell signalling for toxin production in Clostridium perfringens","volume":"44","author":"Ohtani","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB15_1","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1128\/IAI.70.8.4099-4105.2002","article-title":"LuxS-mediated quorum sensing in Borrelia burgdorferi, the lyme disease spirochete","volume":"70","author":"Stevenson","year":"2002","journal-title":"Infect Immun."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.1365-2958.1999.01199.x","article-title":"Regulation of autoinducer production in Salmonella typhimurium","volume":"31","author":"Surette","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB17_1","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1128\/JB.183.9.2918-2928.2001","article-title":"Mapping stress-induced changes in autoinducer AI-2 production in chemostat-cultivated Escherichia coli K-12","volume":"183","author":"DeLisa","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB18","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1128\/JB.184.13.3450-3456.2002","article-title":"pfs-dependent regulation of autoinducer 2 production in Salmonella enterica serovar typhimurium","volume":"184","author":"Beeston","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB19_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1046\/j.1365-2958.2001.02669.x","article-title":"The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium","volume":"42","author":"Taga","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB20_1","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.1128\/IAI.69.12.7625-7634.2001","article-title":"Intra- and interspecies regulation of gene expression by Actinobacillus actinomycetemcomitans LuxS","volume":"69","author":"Fong","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB21","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1099\/00221287-148-5-1475","article-title":"Quorum sensing in Campylobacter jejuni: detection of a luxS encoded signalling molecule","volume":"148","author":"Elvers","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/S1369-5274(03)00028-6_BIB22_1","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1128\/JB.183.18.5239-5247.2001","article-title":"DNA microarray-based identification of genes controlled by autoinducer 2-stimulated quorum sensing in Escherichia coli","volume":"183","author":"DeLisa","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB23","doi-asserted-by":"crossref","first-page":"15196","DOI":"10.1073\/pnas.96.26.15196","article-title":"Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli","volume":"96","author":"Sperandio","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB24","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1365-2958.2002.02803.x","article-title":"Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli","volume":"43","author":"Sperandio","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB25","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1128\/IAI.70.6.3085-3093.2002","article-title":"Quorum-sensing Escherichia coli regulator A: a regulator of the LysR family involved in the regulation of the locus of enterocyte effacement pathogenicity island in enterohemorrhagic E. coli","volume":"70","author":"Sperandio","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1365-2958.2002.02899.x","article-title":"The flagella of enteropathogenic Escherichia coli mediate adherence to epithelial cells","volume":"44","author":"Giron","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB27","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1128\/IAI.70.4.2245-2248.2002","article-title":"Role of Neisseria meningitidis luxS in cell-to-cell signaling and bacteremic infection","volume":"70","author":"Winzer","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB28","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1128\/JB.183.13.3903-3909.2001","article-title":"Signaling system in Porphyromonas gingivalis based on a LuxS protein","volume":"183","author":"Chung","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB29","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1099\/00221287-148-3-763","article-title":"LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence","volume":"148","author":"Burgess","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/S1369-5274(03)00028-6_BIB30","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1128\/IAI.70.5.2640-2649.2002","article-title":"Biofilm formation and interaction with the surfaces of gallstones by Salmonella spp","volume":"70","author":"Prouty","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1128\/IAI.69.1.15-23.2001","article-title":"Shigella flexneri LuxS quorum-sensing system modulates virB expression but is not essential for virulence","volume":"69","author":"Day","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB32_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1365-2958.2001.02616.x","article-title":"Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes","volume":"42","author":"Lyon","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB33_1","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1073\/pnas.052694299","article-title":"Quorum-sensing regulators control virulence gene expression in Vibrio cholerae","volume":"99","author":"Zhu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB34","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1046\/j.1365-2958.2000.01913.x","article-title":"Regulation of quorum sensing in Vibrio harveyi by LuxO and sigma-54","volume":"36","author":"Lilley","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S1369-5274(03)00028-6_BIB35_1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1128\/JB.185.1.274-284.2003","article-title":"LuxS-based signaling in Streptococcus gordonii: autoinducer 2 controls carbohydrate metabolism and biofilm formation with Porphyromonas gingivalis","volume":"185","author":"McNab","year":"2003","journal-title":"J. Bacteriol."}],"container-title":["Current Opinion in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527403000286?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527403000286?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,24]],"date-time":"2019-03-24T06:26:56Z","timestamp":1553408816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369527403000286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S1369527403000286"],"URL":"https:\/\/doi.org\/10.1016\/s1369-5274(03)00028-6","relation":{},"ISSN":["1369-5274"],"issn-type":[{"value":"1369-5274","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}