{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:37:55Z","timestamp":1776839875270,"version":"3.51.2"},"reference-count":11,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Oncology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/s1470-2045(20)30727-0","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T18:48:56Z","timestamp":1606416536000},"page":"19-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["Carcinogenicity of acrolein, crotonaldehyde, and arecoline"],"prefix":"10.1016","volume":"22","author":[{"given":"M Matilde","family":"Marques","sequence":"first","affiliation":[]},{"given":"Frederick A","family":"Beland","sequence":"additional","affiliation":[]},{"given":"Dirk W","family":"Lachenmeier","sequence":"additional","affiliation":[]},{"given":"David H","family":"Phillips","sequence":"additional","affiliation":[]},{"given":"Fung-Lung","family":"Chung","sequence":"additional","affiliation":[]},{"given":"David C","family":"Dorman","sequence":"additional","affiliation":[]},{"given":"Sarah E","family":"Elmore","sequence":"additional","affiliation":[]},{"given":"S Katharine","family":"Hammond","sequence":"additional","affiliation":[]},{"given":"Srmena","family":"Krstev","sequence":"additional","affiliation":[]},{"given":"Igor","family":"Linhart","sequence":"additional","affiliation":[]},{"given":"Alexandra S","family":"Long","sequence":"additional","affiliation":[]},{"given":"Daniele","family":"Mandrioli","sequence":"additional","affiliation":[]},{"given":"Kumiko","family":"Ogawa","sequence":"additional","affiliation":[]},{"given":"Jane J","family":"Pappas","sequence":"additional","affiliation":[]},{"given":"Juan M","family":"Parra Morte","sequence":"additional","affiliation":[]},{"given":"Glenn","family":"Talaska","sequence":"additional","affiliation":[]},{"given":"Moon-shong","family":"Tang","sequence":"additional","affiliation":[]},{"given":"Nisha","family":"Thakur","sequence":"additional","affiliation":[]},{"given":"Martie","family":"van Tongeren","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Vineis","sequence":"additional","affiliation":[]},{"given":"Yann","family":"Grosse","sequence":"additional","affiliation":[]},{"given":"Lamia","family":"Benbrahim-Tallaa","sequence":"additional","affiliation":[]},{"given":"Eero","family":"Suonio","sequence":"additional","affiliation":[]},{"given":"Michelle C","family":"Turner","sequence":"additional","affiliation":[]},{"given":"Fatiha","family":"El Ghissassi","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Middleton","sequence":"additional","affiliation":[]},{"given":"Adalberto","family":"Miranda-Filho","sequence":"additional","affiliation":[]},{"given":"Felicia","family":"Chung","sequence":"additional","affiliation":[]},{"given":"Yaqi","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Samantha","family":"Vega","sequence":"additional","affiliation":[]},{"given":"Heidi","family":"Mattock","sequence":"additional","affiliation":[]},{"given":"Mary K","family":"Schubauer-Berigan","sequence":"additional","affiliation":[]},{"given":"Kathryn Z","family":"Guyton","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1470-2045(20)30727-0_bib1","unstructured":"International Agency for Research on Cancer. Volume 128: acrolein, crotonaldehyde, and arecoline. IARC Working Group. Lyon, France; Oct 29\u2013Nov 13, 2020; IARC Monogr Identif Carcinog Hazards Hum (in press)."},{"key":"10.1016\/S1470-2045(20)30727-0_bib2","series-title":"Summary of inhalation carcinogenicity study of acrolein in B6D2F1 mice","year":"2016"},{"key":"10.1016\/S1470-2045(20)30727-0_bib3","series-title":"Summary of inhalation carcinogenicity study of acrolein in F344 rats","year":"2016"},{"key":"10.1016\/S1470-2045(20)30727-0_bib4","first-page":"581","article-title":"1,N2-propanodeoxyguanosine adducts: potential new biomarkers of smoking-induced DNA damage in human oral tissue","volume":"58","author":"Nath","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S1470-2045(20)30727-0_bib5","doi-asserted-by":"crossref","first-page":"8543","DOI":"10.1021\/ac201874d","article-title":"Quantitative analysis of multiple exocyclic DNA adducts in human salivary DNA by stable isotope dilution nanoflow liquid chromatography-nanospray ionization tandem mass spectrometry","volume":"83","author":"Chen","year":"2011","journal-title":"Anal Chem"},{"key":"10.1016\/S1470-2045(20)30727-0_bib6","doi-asserted-by":"crossref","first-page":"15404","DOI":"10.1073\/pnas.0607031103","article-title":"Acrolein is a major cigarette-related lung cancer agent: preferential binding at p53 mutational hotspots and inhibition of DNA repair","volume":"103","author":"Feng","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S1470-2045(20)30727-0_bib7","first-page":"1285","article-title":"Induction of liver tumors in F344 rats by crotonaldehyde","volume":"46","author":"Chung","year":"1986","journal-title":"Cancer Res"},{"key":"10.1016\/S1470-2045(20)30727-0_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0165-1161(95)00029-1","article-title":"Genotoxic effects of the alpha, beta-unsaturated aldehydes 2-trans-butenal, 2-trans-hexenal and 2-trans, 6-cis-nonadienal","volume":"335","author":"Dittberner","year":"1995","journal-title":"Mutat Res"},{"key":"10.1016\/S1470-2045(20)30727-0_bib9","first-page":"1","article-title":"Personal habits and indoor combustions. Volume 100 E. A review of human carcinogens","volume":"100","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"10.1016\/S1470-2045(20)30727-0_bib10","first-page":"461","article-title":"Micronucleus formation in human lymphocytes and in the metabolically competent human hepatoma cell line Hep-G2: results with 15 naturally occurring substances","volume":"21","author":"Kevekordes","year":"2001","journal-title":"Anticancer Res"},{"key":"10.1016\/S1470-2045(20)30727-0_bib11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tox.2008.05.007","article-title":"Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cells","volume":"249","author":"Tsai","year":"2008","journal-title":"Toxicology"}],"container-title":["The Lancet Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470204520307270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470204520307270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T06:27:22Z","timestamp":1761460042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1470204520307270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S1470204520307270"],"URL":"https:\/\/doi.org\/10.1016\/s1470-2045(20)30727-0","relation":{},"ISSN":["1470-2045"],"issn-type":[{"value":"1470-2045","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carcinogenicity of acrolein, crotonaldehyde, and arecoline","name":"articletitle","label":"Article Title"},{"value":"The Lancet Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1470-2045(20)30727-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}