{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T19:51:37Z","timestamp":1719258697618},"reference-count":9,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet Neurology"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/s1474-4422(10)70085-5","type":"journal-article","created":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T08:35:39Z","timestamp":1270197339000},"page":"449-451","source":"Crossref","is-referenced-by-count":7,"title":["Lithium time-to-event trial in amyotrophic lateral sclerosis stops early for futility"],"prefix":"10.1016","volume":"9","author":[{"given":"Michael","family":"Swash","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1474-4422(10)70085-5_bib1","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0140-6736(96)91680-3","article-title":"Dose-ranging study of riluzole in amyotrophic lateral sclerosis","volume":"347","author":"Lacomblez","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/S1474-4422(10)70085-5_bib2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2147\/NDT.S7788","article-title":"Current and emerging treatments for amyotrophic lateral sclerosis","volume":"5","author":"Zocolella","year":"2009","journal-title":"Neuropsychiat Dis Treat"},{"key":"10.1016\/S1474-4422(10)70085-5_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/17482960701856300","article-title":"Design, power, and interpretation of studies in the standard murine model of ALS","volume":"9","author":"Scott","year":"2008","journal-title":"Amyotroph Lat Scler"},{"key":"10.1016\/S1474-4422(10)70085-5_bib4","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1073\/pnas.0708022105","article-title":"Lithium delays progression of amyotrophic lateral sclerosis","volume":"105","author":"Fornai","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S1474-4422(10)70085-5_bib5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4161\/auto.5923","article-title":"Autophagy and amyotrophic lateral sclerosis; the multiple roles of lithium","volume":"4","author":"Fornai","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/S1474-4422(10)70085-5_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/17482960902803440","article-title":"Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice","volume":"10","author":"Pizzasegola","year":"2009","journal-title":"Amyotroph Lat Scler"},{"key":"10.1016\/S1474-4422(10)70085-5_bib7","doi-asserted-by":"crossref","first-page":"e6489","DOI":"10.1371\/journal.pone.0006489","article-title":"No benefit from chronic lithium dosing in a sibling-matched, gender-balanced, investigator-blinded trial using a standard mouse model of familial ALS","volume":"4","author":"Gill","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/S1474-4422(10)70085-5_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/S1474-4422(10)70068-5","article-title":"Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial","author":"Aggarwal","year":"2010","journal-title":"Lancet Neurology"},{"key":"10.1016\/S1474-4422(10)70085-5_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2006.12.015","article-title":"Lost in translation; treatment trials in the SOD1 mouse and in human amyotrophic lateral sclerosis","volume":"26","author":"Benatar","year":"2007","journal-title":"Neurobiol Dis"}],"container-title":["The Lancet Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1474442210700855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1474442210700855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T04:24:22Z","timestamp":1544588662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1474442210700855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S1474442210700855"],"URL":"https:\/\/doi.org\/10.1016\/s1474-4422(10)70085-5","relation":{},"ISSN":["1474-4422"],"issn-type":[{"value":"1474-4422","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}