{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:58:10Z","timestamp":1767981490018,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002977","name":"Dalhousie University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011898","name":"Marcus och Amalia Wallenbergs minnesfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000848","name":"University of Edinburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000360","name":"Scottish Funding Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005992","name":"Ministry of Education and Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000364","name":"Stroke Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007919","name":"Chest Heart and Stroke Scotland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007919","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000724","name":"Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Schweizerische Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Neurology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/s1474-4422(13)70130-3","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T22:01:47Z","timestamp":1371765707000},"page":"768-776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"title":["Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial"],"prefix":"10.1016","volume":"12","member":"78","reference":[{"key":"10.1016\/S1474-4422(13)70130-3_bib1","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/S0140-6736(12)60738-7","article-title":"Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis","volume":"379","author":"Wardlaw","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/S1474-4422(13)70130-3_bib2","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1016\/S0140-6736(12)60768-5","article-title":"The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial","volume":"379","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/S1474-4422(13)70130-3_bib3","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1056\/NEJM199906103402302","article-title":"Effects of tissue plasminogen activator for acute ischemic stroke at one year","volume":"340","author":"Kwiatkowski","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/S1474-4422(13)70130-3_bib4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1745-6215-9-37","article-title":"The third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke","volume":"9","author":"Sandercock","year":"2008","journal-title":"Trials"},{"key":"10.1016\/S1474-4422(13)70130-3_bib5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1747-4949.2012.00782.x","article-title":"Statistical analysis plan for the third International Stroke Trial (IST-3); part of a \u2018thread\u2019 of reports of the trial","volume":"7","author":"Sandercock","year":"2012","journal-title":"Int J Stroke"},{"key":"10.1016\/S1474-4422(13)70130-3_bib6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1745-6215-12-252","article-title":"Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited","volume":"12","author":"Sandercock","year":"2011","journal-title":"Trials"},{"key":"10.1016\/S1474-4422(13)70130-3_bib7","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1161\/STROKEAHA.111.613273","article-title":"Simplified modified Rankin scale questionnaire: reproducibility over the telephone and validation with quality of life","volume":"42","author":"Bruno","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/S1474-4422(13)70130-3_bib8","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1161\/STROKEAHA.111.639708","article-title":"Determining the modified Rankin score after stroke by postal and telephone questionnaires","volume":"43","author":"Dennis","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/S1474-4422(13)70130-3_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/jnnp.53.1.16","volume":"53","author":"Bamford","year":"1990","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/S1474-4422(13)70130-3_bib10","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.STR.19.5.604","article-title":"Interobserver agreement for the assessment of handicap in stroke patients","volume":"19","author":"van Swieten","year":"1988","journal-title":"Stroke"},{"key":"10.1016\/S1474-4422(13)70130-3_bib11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0168-8510(90)90421-9","article-title":"EuroQol\u2014a new facility for the measurement of health-related quality of life","volume":"16","year":"1990","journal-title":"Health Policy"},{"key":"10.1016\/S1474-4422(13)70130-3_bib12","series-title":"EuroQol Group Monographs; EQ5D value sets; inventory, comparative review and user guide","year":"2007"},{"key":"10.1016\/S1474-4422(13)70130-3_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1477-7525-8-13","article-title":"A review of health utilities using the EQ-5D in studies of cardiovascular disease","volume":"8","author":"Dyer","year":"2010","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/S1474-4422(13)70130-3_bib14","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/bmj.315.7106.461","article-title":"A randomised comparison of the EuroQol and Short Form-36 after stroke","volume":"315","author":"Dorman","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/S1474-4422(13)70130-3_bib15","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1161\/01.STR.28.10.1883","article-title":"Are proxy assessments of health status after stroke with the EuroQol questionnaire feasible, accurate and unbiased?","volume":"28","author":"Dorman","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/S1474-4422(13)70130-3_bib16","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1161\/01.STR.28.10.1876","article-title":"Is the EuroQol a valid measure of health-related quality of life after stroke?","volume":"28","author":"Dorman","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/S1474-4422(13)70130-3_bib17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/jnnp.69.4.487","article-title":"Are the modified \u201csimple questions\u201d a valid and reliable measure of health related quality of life after stroke?","volume":"69","author":"Dorman","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/S1474-4422(13)70130-3_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11136-004-3928-3","article-title":"Responsiveness of generic health-related quality of life measures in stroke","volume":"14","author":"Pickard","year":"2005","journal-title":"Qual Life Res"},{"key":"10.1016\/S1474-4422(13)70130-3_bib19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/01.STR.0000110984.91157.BD","article-title":"Agreement between patient and proxy assessments of health-related quality of life after stroke using the EQ-5D and Health Utilities Index","volume":"35","author":"Pickard","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/S1474-4422(13)70130-3_bib20","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0140-6736(97)04011-7","article-title":"The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19\u2008435 patients with acute ischaemic stroke","volume":"349","author":"Sandercock","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/S1474-4422(13)70130-3_bib21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/STROKEAHA.112.674622","article-title":"Thrombolysis in stroke despite contraindications or warnings?","volume":"44","author":"Frank","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/S1474-4422(13)70130-3_bib22","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/STROKEAHA.107.505867","article-title":"Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials","volume":"39","author":"Konig","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/S1474-4422(13)70130-3_bib23","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1056\/NEJMoa1001508","article-title":"Quality of life after PCI with drug-eluting stents or coronary-artery bypass surgery","volume":"364","author":"Cohen","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/S1474-4422(13)70130-3_bib24","series-title":"A systematic review of the effectiveness, cost-effectiveness and barriers to the implementation of thrombolytic and neuroprotective treatment in the NHS. Health Technology Assessment 6[26]","author":"Sandercock","year":"2002"},{"key":"10.1016\/S1474-4422(13)70130-3_bib25","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1161\/STROKEAHA.112.656876","article-title":"In anticipation of International Stroke Trial-3 (IST-3)","volume":"43","author":"Lyden","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/S1474-4422(13)70130-3_bib26","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1001\/jama.2013.879","article-title":"Reporting of patient-reported outcomes in randomized trials: the consort PRO extension","volume":"309","author":"Calvert","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/S1474-4422(13)70130-3_bib27","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/ijs.12040","article-title":"Details of a prospective protocol for a collaborative meta-analysis of individual participant data from all randomized trials of intravenous rt-PA vs. control: statistical analysis plan for the Stroke Thrombolysis Trialists' Collaborative meta-analysis","volume":"8","year":"2013","journal-title":"Int J Stroke"}],"container-title":["The Lancet Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1474442213701303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1474442213701303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T10:15:23Z","timestamp":1761473723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1474442213701303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S1474442213701303"],"URL":"https:\/\/doi.org\/10.1016\/s1474-4422(13)70130-3","relation":{},"ISSN":["1474-4422"],"issn-type":[{"value":"1474-4422","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial","name":"articletitle","label":"Article Title"},{"value":"The Lancet Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1474-4422(13)70130-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/S1474-4422(13)70149-2","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The IST-3 collaborative group. Open Access article distributed under the terms of CC BY. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}