{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:31:30Z","timestamp":1771471890211,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009281","name":"Fondation Thierry Latran","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FTLDc O1GI1007A"],"award-info":[{"award-number":["FTLDc O1GI1007A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["103838"],"award-info":[{"award-number":["103838"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["01ED1512"],"award-info":[{"award-number":["01ED1512"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","award":["01ED1512\/AC14\/00013"],"award-info":[{"award-number":["01ED1512\/AC14\/00013"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011727","name":"Stockholm l\u00e4ns landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1279"],"award-info":[{"award-number":["SFB1279"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["VO2028"],"award-info":[{"award-number":["VO2028"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["733051024"],"award-info":[{"award-number":["733051024"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["733051042"],"award-info":[{"award-number":["733051042"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["20143810"],"award-info":[{"award-number":["20143810"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010573","name":"Stichting Dioraphte","doi-asserted-by":"publisher","award":["1402 1300"],"award-info":[{"award-number":["1402 1300"]}],"id":[{"id":"10.13039\/501100010573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013669","name":"Ionis Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000143","name":"Alzheimer Society","doi-asserted-by":"publisher","award":["AS-PG-15-025"],"award-info":[{"award-number":["AS-PG-15-025"]}],"id":[{"id":"10.13039\/501100000143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2015-02926"],"award-info":[{"award-number":["2015-02926"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02754"],"award-info":[{"award-number":["2018-02754"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["529-2014-7504"],"award-info":[{"award-number":["529-2014-7504"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M008525\/1"],"award-info":[{"award-number":["MR\/M008525\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M023664\/1"],"award-info":[{"award-number":["MR\/M023664\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Neurology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/s1474-4422(19)30354-0","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T18:30:14Z","timestamp":1573065014000},"page":"1103-1111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":164,"title":["Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study"],"prefix":"10.1016","volume":"18","author":[{"given":"Emma L","family":"van der Ende","sequence":"first","affiliation":[]},{"given":"Lieke H","family":"Meeter","sequence":"additional","affiliation":[]},{"given":"Jackie M","family":"Poos","sequence":"additional","affiliation":[]},{"given":"Jessica L","family":"Panman","sequence":"additional","affiliation":[]},{"given":"Lize C","family":"Jiskoot","sequence":"additional","affiliation":[]},{"given":"Elise G P","family":"Dopper","sequence":"additional","affiliation":[]},{"given":"Janne M","family":"Papma","sequence":"additional","affiliation":[]},{"given":"Frank Jan","family":"de Jong","sequence":"additional","affiliation":[]},{"given":"Inge M W","family":"Verberk","sequence":"additional","affiliation":[]},{"given":"Charlotte","family":"Teunissen","sequence":"additional","affiliation":[]},{"given":"Dimitris","family":"Rizopoulos","sequence":"additional","affiliation":[]},{"given":"Carolin","family":"Heller","sequence":"additional","affiliation":[]},{"given":"Rhian S","family":"Convery","sequence":"additional","affiliation":[]},{"given":"Katrina M","family":"Moore","sequence":"additional","affiliation":[]},{"given":"Martina","family":"Bocchetta","sequence":"additional","affiliation":[]},{"given":"Mollie","family":"Neason","sequence":"additional","affiliation":[]},{"given":"David M","family":"Cash","sequence":"additional","affiliation":[]},{"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Sanchez-Valle","sequence":"additional","affiliation":[]},{"suffix":"Jr","given":"Robert","family":"Laforce","sequence":"additional","affiliation":[]},{"given":"Fermin","family":"Moreno","sequence":"additional","affiliation":[]},{"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[]},{"given":"Caroline","family":"Graff","sequence":"additional","affiliation":[]},{"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Carmela Tartaglia","sequence":"additional","affiliation":[]},{"given":"James B","family":"Rowe","sequence":"additional","affiliation":[]},{"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[]},{"given":"Elizabeth","family":"Finger","sequence":"additional","affiliation":[]},{"given":"Fabrizio","family":"Tagliavini","sequence":"additional","affiliation":[]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[]},{"given":"Chris","family":"Butler","sequence":"additional","affiliation":[]},{"given":"Simon","family":"Ducharme","sequence":"additional","affiliation":[]},{"given":"Alex","family":"Gerhard","sequence":"additional","affiliation":[]},{"given":"Adrian","family":"Danek","sequence":"additional","affiliation":[]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[]},{"given":"Giovanni B","family":"Frisoni","sequence":"additional","affiliation":[]},{"given":"Stefano","family":"Cappa","sequence":"additional","affiliation":[]},{"given":"Yolande A L","family":"Pijnenburg","sequence":"additional","affiliation":[]},{"given":"Jonathan D","family":"Rohrer","sequence":"additional","affiliation":[]},{"given":"John C","family":"van Swieten","sequence":"additional","affiliation":[]},{"given":"Martin N.","family":"Rossor","sequence":"additional","affiliation":[]},{"given":"Jason D.","family":"Warren","sequence":"additional","affiliation":[]},{"given":"Nick C.","family":"Fox","sequence":"additional","affiliation":[]},{"given":"Ione O.C.","family":"Woollacott","sequence":"additional","affiliation":[]},{"given":"Rachelle","family":"Shafei","sequence":"additional","affiliation":[]},{"given":"Caroline","family":"Greaves","sequence":"additional","affiliation":[]},{"given":"Rita","family":"Guerreiro","sequence":"additional","affiliation":[]},{"given":"Jose","family":"Bras","sequence":"additional","affiliation":[]},{"given":"David L.","family":"Thomas","sequence":"additional","affiliation":[]},{"given":"Jennifer","family":"Nicholas","sequence":"additional","affiliation":[]},{"given":"Simon","family":"Mead","sequence":"additional","affiliation":[]},{"given":"Rick","family":"van Minkelen","sequence":"additional","affiliation":[]},{"given":"Myriam","family":"Barandiaran","sequence":"additional","affiliation":[]},{"given":"Bego\u00f1a","family":"Indakoetxea","sequence":"additional","affiliation":[]},{"given":"Alazne","family":"Gabilondo","sequence":"additional","affiliation":[]},{"given":"Mikel","family":"Tainta","sequence":"additional","affiliation":[]},{"given":"Maria","family":"de Arriba","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Gorostidi","sequence":"additional","affiliation":[]},{"given":"Miren","family":"Zulaica","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Villanua","sequence":"additional","affiliation":[]},{"given":"Zigor","family":"Diaz","sequence":"additional","affiliation":[]},{"given":"Sergi","family":"Borrego-Ecija","sequence":"additional","affiliation":[]},{"given":"Jaume","family":"Olives","sequence":"additional","affiliation":[]},{"given":"Albert","family":"Llad\u00f3","sequence":"additional","affiliation":[]},{"given":"Mircea","family":"Balasa","sequence":"additional","affiliation":[]},{"given":"Anna","family":"Antonell","sequence":"additional","affiliation":[]},{"given":"Nuria","family":"Bargallo","sequence":"additional","affiliation":[]},{"given":"Enrico","family":"Premi","sequence":"additional","affiliation":[]},{"given":"Maura","family":"Cosseddu","sequence":"additional","affiliation":[]},{"given":"Stefano","family":"Gazzina","sequence":"additional","affiliation":[]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[]},{"given":"Roberto","family":"Gasparotti","sequence":"additional","affiliation":[]},{"given":"Silvana","family":"Archetti","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Black","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Mitchell","sequence":"additional","affiliation":[]},{"given":"Ekaterina","family":"Rogaeva","sequence":"additional","affiliation":[]},{"given":"Morris","family":"Freedman","sequence":"additional","affiliation":[]},{"given":"Ron","family":"Keren","sequence":"additional","affiliation":[]},{"given":"David","family":"Tang-Wai","sequence":"additional","affiliation":[]},{"given":"Linn","family":"\u00d6ijerstedt","sequence":"additional","affiliation":[]},{"given":"Christin","family":"Andersson","sequence":"additional","affiliation":[]},{"given":"Vesna","family":"Jelic","sequence":"additional","affiliation":[]},{"given":"Hakan","family":"Thonberg","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Arighi","sequence":"additional","affiliation":[]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[]},{"given":"Elio","family":"Scarpini","sequence":"additional","affiliation":[]},{"given":"Giorgio","family":"Fumagalli","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Cope","sequence":"additional","affiliation":[]},{"given":"Carolyn","family":"Timberlake","sequence":"additional","affiliation":[]},{"given":"Timothy","family":"Rittman","sequence":"additional","affiliation":[]},{"given":"Christen","family":"Shoesmith","sequence":"additional","affiliation":[]},{"given":"Robart","family":"Bartha","sequence":"additional","affiliation":[]},{"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[]},{"given":"Carlo","family":"Wilke","sequence":"additional","affiliation":[]},{"given":"Hans-Otto","family":"Karnath","sequence":"additional","affiliation":[]},{"given":"Benjamin","family":"Bender","sequence":"additional","affiliation":[]},{"given":"Rose","family":"Bruffaerts","sequence":"additional","affiliation":[]},{"given":"Philip","family":"Vandamme","sequence":"additional","affiliation":[]},{"given":"Mathieu","family":"Vandenbulcke","sequence":"additional","affiliation":[]},{"given":"Catarina B.","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Gabriel","family":"Miltenberger","sequence":"additional","affiliation":[]},{"given":"Carolina","family":"Maruta","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Verdelho","sequence":"additional","affiliation":[]},{"given":"S\u00f3nia","family":"Afonso","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Taipa","sequence":"additional","affiliation":[]},{"given":"Paola","family":"Caroppo","sequence":"additional","affiliation":[]},{"given":"Giuseppe","family":"Di Fede","sequence":"additional","affiliation":[]},{"given":"Giorgio","family":"Giaccone","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Prioni","sequence":"additional","affiliation":[]},{"given":"Veronica","family":"Redaelli","sequence":"additional","affiliation":[]},{"given":"Giacomina","family":"Rossi","sequence":"additional","affiliation":[]},{"given":"Pietro","family":"Tiraboschi","sequence":"additional","affiliation":[]},{"given":"Diana","family":"Duro","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Rosario Almeida","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Jo\u00e3o Leit\u00e3o","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Tabuas-Pereira","sequence":"additional","affiliation":[]},{"given":"Beatriz","family":"Santiago","sequence":"additional","affiliation":[]},{"given":"Serge","family":"Gauthier","sequence":"additional","affiliation":[]},{"given":"Sonja","family":"Schonecker","sequence":"additional","affiliation":[]},{"given":"Elisa","family":"Semler","sequence":"additional","affiliation":[]},{"given":"Sarah","family":"Anderl-Straub","sequence":"additional","affiliation":[]},{"given":"Luisa","family":"Benussi","sequence":"additional","affiliation":[]},{"given":"Giuliano","family":"Binetti","sequence":"additional","affiliation":[]},{"given":"Roberta","family":"Ghidoni","sequence":"additional","affiliation":[]},{"given":"Michela","family":"Pievani","sequence":"additional","affiliation":[]},{"given":"Gemma","family":"Lombardi","sequence":"additional","affiliation":[]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[]},{"given":"Camilla","family":"Ferrari","sequence":"additional","affiliation":[]},{"given":"Valentina","family":"Bessi","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1474-4422(19)30354-0_bib1","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"10.1016\/S1474-4422(19)30354-0_bib2","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/S1474-4422(19)30354-0_bib3","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/nan.12250","article-title":"Review: an update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations","volume":"41","author":"Lashley","year":"2015","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/acn3.325","article-title":"Neurofilament light chain: a biomarker for genetic frontotemporal dementia","volume":"3","author":"Meeter","year":"2016","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib5","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1212\/WNL.0000000000003154","article-title":"Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia","volume":"87","author":"Rohrer","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/S1474-4422(19)30354-0_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/ana.24052","article-title":"Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration","volume":"75","author":"Scherling","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib7","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41582-018-0058-z","article-title":"Neurofilaments as biomarkers in neurological disorders","volume":"14","author":"Khalil","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fneur.2019.00338","article-title":"Neurofilament light chain as a biomarker in multiple sclerosis","volume":"10","author":"Varhaug","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuron.2016.05.018","article-title":"Neurofilament light chain in blood and CSF as marker of disease progression in mouse models and in neurodegenerative diseases","volume":"91","author":"Bacioglu","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/S1474-4422(19)30354-0_bib10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(14)70324-2","article-title":"Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis","volume":"14","author":"Rohrer","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1016\/S1474-4422(19)30354-0_bib12","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1109\/TMI.2015.2418298","article-title":"Geodesic information flows: spatially-variant graphs and their application to segmentation and fusion","volume":"34","author":"Cardoso","year":"2015","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/S1474-4422(19)30354-0_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0169-2607(97)01803-8","article-title":"Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans","volume":"53","author":"Freeborough","year":"1997","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1016\/S1474-4422(19)30354-0_bib14","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.neuroimage.2014.09.034","article-title":"Accurate automatic estimation of total intracranial volume: a nuisance variable with less nuisance","volume":"104","author":"Malone","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/S1474-4422(19)30354-0_bib15","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1212\/01.wnl.0000319702.37497.72","article-title":"Distinct genetic forms of frontotemporal dementia","volume":"71","author":"Seelaar","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/S1474-4422(19)30354-0_bib16","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S1474-4422(08)70194-7","article-title":"Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia","volume":"7","author":"van Swieten","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13195-018-0364-0","article-title":"Diagnostic value of cerebrospinal fluid tau, neurofilament, and progranulin in definite frontotemporal lobar degeneration","volume":"10","author":"Goossens","year":"2018","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/S1474-4422(19)30354-0_bib18","doi-asserted-by":"crossref","first-page":"e1390","DOI":"10.1212\/WNL.0000000000006318","article-title":"Serum neurofilament light chain in behavioral variant frontotemporal dementia","volume":"91","author":"Steinacker","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/S1474-4422(19)30354-0_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.nicl.2017.04.015","article-title":"White matter hyperintensities are seen only in GRN mutation carriers in the GENFI cohort","volume":"15","author":"Sudre","year":"2017","journal-title":"Neuroimage Clin"},{"key":"10.1016\/S1474-4422(19)30354-0_bib20","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/ana.25276","article-title":"Neurofilament light: a candidate biomarker of presymptomatic amyotrophic lateral sclerosis and phenoconversion","volume":"84","author":"Benatar","year":"2018","journal-title":"Ann Neurol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13195-019-0472-5","article-title":"Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer's disease","volume":"11","author":"Weston","year":"2019","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/S1474-4422(19)30354-0_bib22","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1212\/WNL.0000000000001642","article-title":"Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis","volume":"84","author":"Lu","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/S1474-4422(19)30354-0_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/jnnp-2018-318704","article-title":"Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis","volume":"90","author":"Verde","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/S1474-4422(19)30354-0_bib24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41591-018-0304-3","article-title":"Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease","volume":"25","author":"Preische","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/S1474-4422(19)30354-0_bib25","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1093\/brain\/awx198","article-title":"Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease","volume":"140","author":"Chitramuthu","year":"2017","journal-title":"Brain"},{"key":"10.1016\/S1474-4422(19)30354-0_bib26","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1212\/WNL.0000000000003688","article-title":"Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias","volume":"88","author":"Steinacker","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/S1474-4422(19)30354-0_bib27","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1001\/jamaneurol.2019.0765","article-title":"Association Between longitudinal plasma neurofilament light and neurodegeneration in patients with Alzheimer disease","volume":"76","author":"Mattsson","year":"2019","journal-title":"JAMA Neurol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nrneurol.2017.75","article-title":"Imaging and fluid biomarkers in frontotemporal dementia","volume":"13","author":"Meeter","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib29","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1468-1331.2009.02853.x","article-title":"Cerebrospinal fluid and serum antibodies against neurofilaments in patients with amyotrophic lateral sclerosis","volume":"17","author":"Fialova","year":"2010","journal-title":"Eur J Neurol"},{"key":"10.1016\/S1474-4422(19)30354-0_bib30","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1136\/jnnp-2013-305494","article-title":"Immune reactivity to neurofilament proteins in the clinical staging of amyotrophic lateral sclerosis","volume":"85","author":"Puentes","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/S1474-4422(19)30354-0_bib31","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1515\/cclm-2015-1195","article-title":"Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa","volume":"54","author":"Kuhle","year":"2016","journal-title":"Clin Chem Lab Med"}],"updated-by":[{"DOI":"10.1016\/s1474-4422(19)30455-7","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000}}],"container-title":["The Lancet Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1474442219303540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1474442219303540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T10:20:00Z","timestamp":1761474000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1474442219303540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S1474442219303540"],"URL":"https:\/\/doi.org\/10.1016\/s1474-4422(19)30354-0","relation":{},"ISSN":["1474-4422"],"issn-type":[{"value":"1474-4422","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study","name":"articletitle","label":"Article Title"},{"value":"The Lancet Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1474-4422(19)30354-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/S1474-4422(19)30405-3","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}