{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:07:25Z","timestamp":1777712845613,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Diabetes & Endocrinology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/s2213-8587(21)00019-x","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T18:43:04Z","timestamp":1614624184000},"page":"212-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":166,"title":["Anti-interleukin-21 antibody and liraglutide for the preservation of \u03b2-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial"],"prefix":"10.1016","volume":"9","author":[{"given":"Matthias","family":"von Herrath","sequence":"first","affiliation":[]},{"given":"Stephen C","family":"Bain","sequence":"additional","affiliation":[]},{"given":"Bruce","family":"Bode","sequence":"additional","affiliation":[]},{"given":"Jesper Ole","family":"Clausen","sequence":"additional","affiliation":[]},{"given":"Ken","family":"Coppieters","sequence":"additional","affiliation":[]},{"given":"Leylya","family":"Gaysina","sequence":"additional","affiliation":[]},{"given":"Janusz","family":"Gumprecht","sequence":"additional","affiliation":[]},{"given":"Troels Krarup","family":"Hansen","sequence":"additional","affiliation":[]},{"given":"Chantal","family":"Mathieu","sequence":"additional","affiliation":[]},{"given":"Cristobal","family":"Morales","sequence":"additional","affiliation":[]},{"given":"Ofri","family":"Mosenzon","sequence":"additional","affiliation":[]},{"given":"Stine","family":"Segel","sequence":"additional","affiliation":[]},{"given":"George","family":"Tsoukas","sequence":"additional","affiliation":[]},{"given":"Thomas R","family":"Pieber","sequence":"additional","affiliation":[]},{"given":"Bernhard","family":"Ludvik","sequence":"additional","affiliation":[]},{"given":"Rudolf","family":"Prager","sequence":"additional","affiliation":[]},{"given":"Bernhard","family":"Paulweber","sequence":"additional","affiliation":[]},{"given":"Christoph F","family":"Ebenbichler","sequence":"additional","affiliation":[]},{"given":"B","family":"Keymeulen","sequence":"additional","affiliation":[]},{"given":"C","family":"De Block","sequence":"additional","affiliation":[]},{"given":"Loren","family":"Grossman","sequence":"additional","affiliation":[]},{"given":"Robyn","family":"Houlden","sequence":"additional","affiliation":[]},{"given":"Patrice","family":"Perron","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Ransom","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Senior","sequence":"additional","affiliation":[]},{"given":"S. John","family":"Weisnagel","sequence":"additional","affiliation":[]},{"given":"Vincent","family":"Woo","sequence":"additional","affiliation":[]},{"given":"Richard","family":"Dumas","sequence":"additional","affiliation":[]},{"given":"David","family":"Thompson","sequence":"additional","affiliation":[]},{"given":"Tina","family":"Vilsb\u00f8ll","sequence":"additional","affiliation":[]},{"given":"Jeppe","family":"Gram","sequence":"additional","affiliation":[]},{"given":"Claus Bogh","family":"Juhl","sequence":"additional","affiliation":[]},{"given":"Janne","family":"Hukkanen","sequence":"additional","affiliation":[]},{"given":"Jorma","family":"Lahtela","sequence":"additional","affiliation":[]},{"given":"Leo","family":"Niskanen","sequence":"additional","affiliation":[]},{"given":"Donal","family":"O'Shea","sequence":"additional","affiliation":[]},{"given":"Timothy","family":"O'Brien","sequence":"additional","affiliation":[]},{"given":"Seamus","family":"Sreenan","sequence":"additional","affiliation":[]},{"given":"Julio","family":"Wainstein","sequence":"additional","affiliation":[]},{"given":"Moshe","family":"Phillip","sequence":"additional","affiliation":[]},{"given":"Hilla","family":"Knobler","sequence":"additional","affiliation":[]},{"given":"Francesco","family":"Dotta","sequence":"additional","affiliation":[]},{"given":"Pier Marco","family":"Piatti","sequence":"additional","affiliation":[]},{"given":"Trevisan","family":"Roberto","sequence":"additional","affiliation":[]},{"given":"Agostino","family":"Gnasso","sequence":"additional","affiliation":[]},{"given":"Hanne","family":"Gulseth","sequence":"additional","affiliation":[]},{"given":"John","family":"Cooper","sequence":"additional","affiliation":[]},{"given":"Ewa","family":"Pankowska","sequence":"additional","affiliation":[]},{"given":"Monika","family":"Lukaszewicz","sequence":"additional","affiliation":[]},{"given":"Bogumi\u0142","family":"Wolnik","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Manita","sequence":"additional","affiliation":[]},{"given":"Olinda","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Roque","sequence":"additional","affiliation":[]},{"given":"Rosa Maria","family":"Pr\u00edncipe","sequence":"additional","affiliation":[]},{"given":"Celestino","family":"Neves","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Heitor","sequence":"additional","affiliation":[]},{"given":"L","family":"Ruyatkina","sequence":"additional","affiliation":[]},{"given":"Irina","family":"Dvoryashina","sequence":"additional","affiliation":[]},{"given":"Gulnar","family":"Vagapova","sequence":"additional","affiliation":[]},{"given":"Lidiya","family":"Belousova","sequence":"additional","affiliation":[]},{"given":"Marina","family":"Sergeeva-Kondrachenko","sequence":"additional","affiliation":[]},{"given":"Andrey","family":"Peskov","sequence":"additional","affiliation":[]},{"given":"Elena","family":"Frolova","sequence":"additional","affiliation":[]},{"given":"Albina","family":"Golovach","sequence":"additional","affiliation":[]},{"given":"Marina","family":"Kunitsyna","sequence":"additional","affiliation":[]},{"given":"Natalia","family":"Krasnopeeva (Kabachkova)","sequence":"additional","affiliation":[]},{"given":"Irina","family":"Ipatko","sequence":"additional","affiliation":[]},{"given":"Carmen","family":"De la Cuesta","sequence":"additional","affiliation":[]},{"given":"Francisco Jos\u00e9","family":"Tinahones","sequence":"additional","affiliation":[]},{"given":"Mercedes","family":"Rigla","sequence":"additional","affiliation":[]},{"given":"Juan Francisco","family":"Merino","sequence":"additional","affiliation":[]},{"given":"Luis Alberto","family":"G\u00f3mez","sequence":"additional","affiliation":[]},{"given":"Merc\u00e8","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[]},{"given":"Rafael","family":"Sim\u00f3","sequence":"additional","affiliation":[]},{"given":"Mikael","family":"Ryd\u00e9n","sequence":"additional","affiliation":[]},{"given":"Johan","family":"Jendle","sequence":"additional","affiliation":[]},{"given":"Karin","family":"Filipsson","sequence":"additional","affiliation":[]},{"given":"Bj\u00f6rn","family":"Eliasson","sequence":"additional","affiliation":[]},{"given":"Borys","family":"Mankovsky","sequence":"additional","affiliation":[]},{"given":"Iurii","family":"Lymar","sequence":"additional","affiliation":[]},{"given":"Liubov","family":"Sokolova","sequence":"additional","affiliation":[]},{"given":"Galyna","family":"Myshanych","sequence":"additional","affiliation":[]},{"given":"Tetiana","family":"Zlova","sequence":"additional","affiliation":[]},{"given":"Maryna","family":"Vlasenko","sequence":"additional","affiliation":[]},{"given":"Petro","family":"Kuskalo -","sequence":"additional","affiliation":[]},{"given":"Hamish","family":"Courtney","sequence":"additional","affiliation":[]},{"given":"Colin","family":"Dayan","sequence":"additional","affiliation":[]},{"given":"Patrick","family":"English","sequence":"additional","affiliation":[]},{"given":"Simon","family":"Heller","sequence":"additional","affiliation":[]},{"given":"Andrew B","family":"Johnson","sequence":"additional","affiliation":[]},{"given":"Sunil","family":"Nair","sequence":"additional","affiliation":[]},{"given":"R. D","family":"Leslie","sequence":"additional","affiliation":[]},{"given":"P","family":"Narendran","sequence":"additional","affiliation":[]},{"given":"Nick","family":"Oliver","sequence":"additional","affiliation":[]},{"given":"Shenaz","family":"Ramtoola","sequence":"additional","affiliation":[]},{"given":"Jim","family":"Shaw","sequence":"additional","affiliation":[]},{"given":"Adie","family":"Viljoen -","sequence":"additional","affiliation":[]},{"given":"Amer","family":"Al-Karadsheh","sequence":"additional","affiliation":[]},{"given":"Jean Marie","family":"Dostou","sequence":"additional","affiliation":[]},{"given":"Sumana","family":"Gangi","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Gottlieb","sequence":"additional","affiliation":[]},{"given":"Terri","family":"Jerkins","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Magnotti","sequence":"additional","affiliation":[]},{"given":"Jennifer","family":"Marks","sequence":"additional","affiliation":[]},{"given":"Samer","family":"Nakhle","sequence":"additional","affiliation":[]},{"given":"Gholamreza","family":"Bonabi","sequence":"additional","affiliation":[]},{"given":"Lyle","family":"Myers","sequence":"additional","affiliation":[]},{"given":"Richard","family":"Pratley","sequence":"additional","affiliation":[]},{"given":"William","family":"Hagopian","sequence":"additional","affiliation":[]},{"given":"Jeremy","family":"Pettus","sequence":"additional","affiliation":[]},{"given":"Bernt Johan","family":"von Scholten","sequence":"additional","affiliation":[]},{"given":"Johnna D","family":"Wesley","sequence":"additional","affiliation":[]},{"given":"Frederik F","family":"Kreiner","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S2213-8587(21)00019-X_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2019.107842","article-title":"Worldwide estimates of incidence, prevalence and mortality of type 1 diabetes in children and adolescents: results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Patterson","year":"2019","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/S2213-8587(21)00019-X_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.diabres.2016.09.024","article-title":"Type 1 diabetes in older adults: comparing treatments and chronic complications in the United States T1D exchange and the German\/Austrian DPV registries","volume":"122","author":"Weinstock","year":"2016","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/S2213-8587(21)00019-X_bib3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2337\/dc14-0920","article-title":"Hypoglycemia and risk of cardiovascular disease and all-cause mortality in insulin-treated people with type 1 and type 2 diabetes: a cohort study","volume":"38","author":"Khunti","year":"2015","journal-title":"Diabetes care"},{"key":"10.1016\/S2213-8587(21)00019-X_bib4","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1056\/NEJMoa0904452","article-title":"Rituximab, B-lymphocyte depletion, and preservation of beta-cell function","volume":"361","author":"Pescovitz","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/S2213-8587(21)00019-X_bib5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0140-6736(11)60886-6","article-title":"Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial","volume":"378","author":"Orban","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/S2213-8587(21)00019-X_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0140-6736(86)91943-4","article-title":"Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial","volume":"328","author":"Feutren","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/S2213-8587(21)00019-X_bib7","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.clim.2013.02.002","article-title":"Trials in type 1 diabetes: antigen-specific therapies","volume":"149","author":"Coppieters","year":"2013","journal-title":"Clin Immunol"},{"key":"10.1016\/S2213-8587(21)00019-X_bib8","doi-asserted-by":"crossref","first-page":"838","DOI":"10.4161\/hv.26890","article-title":"Non-antigenic and antigenic interventions in type 1 diabetes","volume":"10","author":"Ryd\u00e9n","year":"2014","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/S2213-8587(21)00019-X_bib9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJMoa1902226","article-title":"An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes","volume":"381","author":"Herold","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/S2213-8587(21)00019-X_bib10","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.2337\/db19-0057","article-title":"Low-dose anti-thymocyte globulin preserves c-peptide, reduces HbA1c, and increases regulatory to conventional t-cell ratios in new-onset type 1 diabetes: two-year clinical trial data","volume":"68","author":"Haller","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/S2213-8587(21)00019-X_bib11","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1172\/JCI81722","article-title":"Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients","volume":"125","author":"Rigby","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/S2213-8587(21)00019-X_bib12","doi-asserted-by":"crossref","first-page":"832","DOI":"10.2337\/diacare.26.3.832","article-title":"\u03b2-cell function and the development of diabetes-related complications in the diabetes control and complications trial","volume":"26","author":"Steffes","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/S2213-8587(21)00019-X_bib13","doi-asserted-by":"crossref","first-page":"517","DOI":"10.7326\/0003-4819-128-7-199804010-00001","article-title":"Effect of intensive therapy on residual \u03b2-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial","volume":"128","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/S2213-8587(21)00019-X_bib14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jcv.2013.01.016","article-title":"Reactivation of latent viruses in individuals receiving rituximab for new onset type 1 diabetes","volume":"57","author":"Kroll","year":"2013","journal-title":"J Clin Virol"},{"key":"10.1016\/S2213-8587(21)00019-X_bib15","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1182\/blood-2009-02-204875","article-title":"Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients","volume":"115","author":"Keymeulen","year":"2010","journal-title":"Blood"},{"key":"10.1016\/S2213-8587(21)00019-X_bib16","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1021\/pr400527q","article-title":"Glucagon-like peptide-1 protects human islets against cytokine-mediated \u03b2-cell dysfunction and death: a proteomic study of the pathways involved","volume":"12","author":"Rondas","year":"2013","journal-title":"J Proteome Res"},{"key":"10.1016\/S2213-8587(21)00019-X_bib17","doi-asserted-by":"crossref","first-page":"14028","DOI":"10.1073\/pnas.0804358105","article-title":"IL-21 signaling is critical for the development of type I diabetes in the NOD mouse","volume":"105","author":"Spolski","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S2213-8587(21)00019-X_bib18","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.2337\/db08-0882","article-title":"Interleukin-21 is required for the development of type 1 diabetes in NOD mice","volume":"58","author":"Sutherland","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/S2213-8587(21)00019-X_bib19","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.humimm.2007.01.009","article-title":"Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes","volume":"68","author":"Asano","year":"2007","journal-title":"Hum Immunol"},{"key":"10.1016\/S2213-8587(21)00019-X_bib20","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00125-015-3509-8","article-title":"IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients","volume":"58","author":"Ferreira","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/S2213-8587(21)00019-X_bib21","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.immuni.2012.04.005","article-title":"Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets","volume":"36","author":"Van Belle","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/S2213-8587(21)00019-X_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3212","article-title":"Liraglutide combined with human umbilical cord mesenchymal stem cell transplantation inhibits beta-cell apoptosis via mediating the ASK1\/JNK\/BAX pathway in rats with type 2 diabetes","volume":"36","author":"Wang","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/S2213-8587(21)00019-X_bib23","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1210\/en.2014-1218","article-title":"GLP-1 analog liraglutide enhances proinsulin processing in pancreatic \u03b2-cells via a PKA-dependent pathway","volume":"155","author":"Wang","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/S2213-8587(21)00019-X_bib24","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.cmet.2018.03.001","article-title":"Mechanisms of action and therapeutic application of glucagon-like peptide-1","volume":"27","author":"Drucker","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/S2213-8587(21)00019-X_bib25","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/postgradmedj-2019-137186","article-title":"An overview of GLP-1 agonists and recent cardiovascular outcomes trials","volume":"96","author":"Sheahan","year":"2020","journal-title":"Postgrad Med J"},{"key":"10.1016\/S2213-8587(21)00019-X_bib26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cmet.2016.10.009","article-title":"Immunotherapy for type 1 diabetes: why do current protocols not halt the underlying disease process?","volume":"25","author":"Kolb","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/S2213-8587(21)00019-X_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s11892-017-0878-z","article-title":"Combination immunotherapy for type 1 diabetes","volume":"17","author":"Bone","year":"2017","journal-title":"Curr Diab Rep"},{"key":"10.1016\/S2213-8587(21)00019-X_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jaut.2017.07.006","article-title":"Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes","volume":"84","author":"Ryd\u00e9n","year":"2017","journal-title":"J Autoimmun"},{"key":"10.1016\/S2213-8587(21)00019-X_bib29","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.2337\/dc12-2480","article-title":"Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society","volume":"36","author":"Seaquist","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/S2213-8587(21)00019-X_bib30","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5414\/CP202474","article-title":"Safety, PK, and PD of recombinant anti-interleukin-21 monoclonal antibody in a first-in-human trial","volume":"54","author":"Ignatenko","year":"2016","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1016\/S2213-8587(21)00019-X_bib31","article-title":"GLP-1 receptor agonists in the treatment of type 2 diabetes\u2013state-of-the-art","author":"Nauck","year":"2020","journal-title":"Mol Metab"},{"key":"10.1016\/S2213-8587(21)00019-X_bib32","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/dme.13960","article-title":"Persistent C-peptide is associated with reduced hypoglycaemia but not HbA1c in adults with longstanding type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?","volume":"36","author":"Marren","year":"2019","journal-title":"Diabet Med"},{"key":"10.1016\/S2213-8587(21)00019-X_bib33","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1210\/jc.2017-01836","article-title":"Impact of C-peptide status on the response of glucagon and endogenous glucose production to induced hypoglycemia in T1DM","volume":"103","author":"Zenz","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/S2213-8587(21)00019-X_bib34","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.2337\/db13-0345","article-title":"Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders","volume":"62","author":"Herold","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/S2213-8587(21)00019-X_bib35","doi-asserted-by":"crossref","first-page":"e2192","DOI":"10.1210\/clinem\/dgaa149","article-title":"Randomized 52-week phase 2 trial of albiglutide versus placebo in adult patients with newly diagnosed type 1 diabetes","volume":"105","author":"Pozzilli","year":"2020","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Lancet Diabetes & Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221385872100019X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221385872100019X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:09:06Z","timestamp":1761991746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221385872100019X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S221385872100019X"],"URL":"https:\/\/doi.org\/10.1016\/s2213-8587(21)00019-x","relation":{},"ISSN":["2213-8587"],"issn-type":[{"value":"2213-8587","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-interleukin-21 antibody and liraglutide for the preservation of \u03b2-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial","name":"articletitle","label":"Article Title"},{"value":"The Lancet Diabetes & Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S2213-8587(21)00019-X","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/S2213-8587(21)00044-9","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}