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We developed rigorous, yet mathematically simple, methodology based on the degeneracy at \u20131 eigenvalues to identify structural symmetry or motif structures in network. Utilizing eigenvectors corresponding to degenerate eigenvalues in the weighted adjacency matrix, we identified structural symmetry in underlying weighted protein\u2013protein interaction networks constructed using seven cancer data. Functional assessment of proteins forming these structural symmetry exhibited the property of cancer hallmarks. Survival analysis refined further this protein list proposing <jats:italic>BMI<\/jats:italic>, <jats:italic>MAPK11<\/jats:italic>, <jats:italic>DDIT4<\/jats:italic>, <jats:italic>CDKN2A<\/jats:italic>, and <jats:italic>FYN<\/jats:italic> as putative multicancer biomarkers. The combined framework of networks and spectral graph theory developed here can be applied to identify symmetrical patterns in other disease networks to predict proteins as potential disease biomarkers.<\/jats:p>","DOI":"10.1017\/nws.2019.55","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T07:41:26Z","timestamp":1577346086000},"page":"541-555","source":"Crossref","is-referenced-by-count":6,"title":["Symmetry in cancer networks identified: Proposal for multicancer biomarkers"],"prefix":"10.1017","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1071-2744","authenticated-orcid":false,"given":"Pramod","family":"Shinde","sequence":"first","affiliation":[]},{"given":"Lo\u00efc","family":"Marrec","sequence":"additional","affiliation":[]},{"given":"Aparna","family":"Rai","sequence":"additional","affiliation":[]},{"given":"Alok","family":"Yadav","sequence":"additional","affiliation":[]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[]},{"given":"Mikhail","family":"Ivanchenko","sequence":"additional","affiliation":[]},{"given":"Alexey","family":"Zaikin","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-6107","authenticated-orcid":false,"given":"Sarika","family":"Jalan","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2019,12,26]]},"reference":[{"key":"S2050124219000559_ref51","doi-asserted-by":"publisher","DOI":"10.1021\/pr500585p"},{"key":"S2050124219000559_ref47","doi-asserted-by":"publisher","DOI":"10.1038\/ng1340"},{"key":"S2050124219000559_ref45","doi-asserted-by":"publisher","DOI":"10.1038\/nature07943"},{"key":"S2050124219000559_ref44","unstructured":"Shinde, P. , Whitwell, H. 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