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NF-\u03baB signalling was assessed using an NF-\u03baB luciferase reporter cell line that was stimulated with TNF-\u03b1 (100\u00a0ng\/ml). p65 Nuclear binding and cytokine secretion (TNF-\u03b1, IL-1\u03b2 and IL-6) were evaluated using a RAW 264\u00b77 macrophage cell line that was exposed to lipopolysaccharide (LPS; 5\u00a0\u03bcg\/ml). Mice were administered vehicle, EC-M17, metronidazole, or EC-M17 plus metronidazole for 13\u00a0d. During the final 6\u00a0d, mice also received 2\u00a0% DSS. Parameters evaluated included disease activity index (DAI), histology, myeloperoxidase and NF-\u03baB p65. EC-M17 dose dependently inhibited TNF-\u03b1-induced NF-\u03baB signalling. At 5\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> colony-forming units\/ml, EC-M17 inhibited NF-\u03baB by &gt;95\u00a0%. LPS-induced nuclear p65 binding was significantly inhibited (78\u00a0%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) in RAW 264\u00b77 macrophages at 1\u00a0\u00d7\u00a010<jats:sup>8<\/jats:sup> colony-forming units\/ml. EC-M17 also inhibited (by &gt;90\u00a0%) the LPS-induced secretion of TNF-\u03b1, IL-1\u03b2 and IL-6. In mice with DSS-induced colitis, EC-M17, metronidazole, and EC-M17 plus metronidazole significantly reduced DAI and colonic histology scores. Both EC-M17 and metronidazole reduced colonic IL-12, IL-6, IL-1\u03b2 and interferon-\u03b3. The combination of EC-M17 plus metronidazole resulted in more substantial cytokine reductions than were found with either treatment alone, and combination therapy significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705 in both cases) reduced IL-1\u03b2 compared with EC-M17 and colonic histology scores compared with metronidazole. Alone, and in combination with metronidazole, EC-M17 improved murine colitis, probably due to an inhibitory effect on NF-\u03baB signalling.<\/jats:p>","DOI":"10.1017\/s0007114508930373","type":"journal-article","created":{"date-parts":[[2008,2,18]],"date-time":"2008-02-18T10:12:12Z","timestamp":1203329532000},"page":"530-541","source":"Crossref","is-referenced-by-count":42,"title":["<i>In vitro<\/i> and <i>in vivo<\/i> effects of the probiotic <i>Escherichia coli<\/i> strain M-17: immunomodulation and attenuation of murine colitis"],"prefix":"10.1017","volume":"100","author":[{"given":"Leo R.","family":"Fitzpatrick","sequence":"first","affiliation":[]},{"given":"Jeffrey","family":"Small","sequence":"additional","affiliation":[]},{"given":"Robert A.","family":"Hoerr","sequence":"additional","affiliation":[]},{"given":"Eileen F.","family":"Bostwick","sequence":"additional","affiliation":[]},{"given":"Lynn","family":"Maines","sequence":"additional","affiliation":[]},{"given":"Walter 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