{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:28:49Z","timestamp":1694636929254},"reference-count":12,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"unspecified","delay-in-days":14014,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[1970,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>When a determinant for neomycin-kanamycin resistance (K) was transferred by an F-<jats:italic>lac<\/jats:italic>factor into<jats:italic>Salmonella typhimurium<\/jats:italic>, the resulting KF-<jats:italic>lac<\/jats:italic>strain was sensitive to the male-specific phage \u03bc<jats:sub>2<\/jats:sub>and F-<jats:italic>lac<\/jats:italic>was derepressed. However, F-<jats:italic>lac<\/jats:italic>alone is repressed in<jats:italic>S. typhimurium<\/jats:italic>. When kanamycin resistance is spontaneously lost from<jats:italic>S. typhimurium<\/jats:italic>KF-<jats:italic>lac<\/jats:italic>an element persists which derepresses F-<jats:italic>lac<\/jats:italic>in<jats:italic>S. typhimurium<\/jats:italic>. The results are consistent with the hypothesis that a locus<jats:italic>der<\/jats:italic>, for derepression of F-<jats:italic>lac<\/jats:italic>in<jats:italic>S. typhimurium<\/jats:italic>, lies on the K plasmid. The R factor Rl<jats:italic>drd<\/jats:italic>19 is derepressed in K12 but is repressed in<jats:italic>S. typhimurium<\/jats:italic>. It also is derepressed by<jats:italic>der<\/jats:italic>. In contrast to F-<jats:italic>lac<\/jats:italic>and R1, another R factor, R136<jats:italic>drd<\/jats:italic>H8, is derepressed in both K12 and<jats:italic>S. typhimurium<\/jats:italic>, so that the intervention of<jats:italic>der<\/jats:italic>is unnecessary for its derepression in the salmonella host.<\/jats:p>","DOI":"10.1017\/s0016672300002627","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T07:52:37Z","timestamp":1253173957000},"page":"349-353","source":"Crossref","is-referenced-by-count":9,"title":["Derepression of F-<i>lac<\/i>in<i>Salmonella typhimurium<\/i>by a determinant for kanamycin resistance"],"prefix":"10.1155","volume":"16","author":[{"given":"H. R.","family":"Smith","sequence":"first","affiliation":[]},{"given":"June N.","family":"Grindley","sequence":"additional","affiliation":[]},{"given":"N. D. F.","family":"Grindley","sequence":"additional","affiliation":[]},{"given":"E. 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