{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T11:14:50Z","timestamp":1699787690048},"reference-count":19,"publisher":"Hindawi Limited","issue":"2","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"unspecified","delay-in-days":15566,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[1966,9]]},"abstract":"<jats:p>The fact that the X-linked genes scurfy (<jats:italic>sf<\/jats:italic>) and sparse-fur (<jats:italic>spf<\/jats:italic>) of the mouse do not produce a mosaic effect in heterozygotes had been taken, by other workers, together with results from X-Autosome translocations, as evidence that inactivation of the mouse X was incomplete. In this paper it is argued that absence of a mosaic effect is not adequate evidence that a gene is not inactivated. The argument was backed by an experiment in which the<jats:italic>spf<\/jats:italic>gene was introduced heterozygously into females carrying an X-linked translocation resulting in non-random X-inactivation with the same X active in all cells. When the mutant (<jats:italic>spf<\/jats:italic>) allele was on the active X its effect was fully expressed, indicating that the normal allele on the structurally normal inactive X was undergoing inactivation. Argument is further presented that results from X-Autosome translocations do not indicate the degree of completeness of inactivation in a structurally normal X. Hence, there is no evidence that inactivation of the mouse X is incomplete, although evidence from XO females does suggest that it may be incomplete in man.<\/jats:p>","DOI":"10.1017\/s0016672300010053","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T07:58:01Z","timestamp":1253174281000},"page":"197-204","source":"Crossref","is-referenced-by-count":21,"title":["Lack of evidence that inactivation of the mouse X-chromosome is incomplete"],"prefix":"10.1155","volume":"8","author":[{"given":"Mary F.","family":"Lyon","sequence":"first","affiliation":[]}],"member":"98","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"S0016672300010053_ref001","first-page":"308","article-title":"Chromosome studies in spontaneous abortions","volume":"26","author":"Carr","year":"1965","journal-title":"Obstet. 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VererbLehre"},{"key":"S0016672300010053_ref004","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2.2.142"},{"key":"S0016672300010053_ref006","first-page":"62","volume-title":"Second International Conference on Congenital Malformations","author":"Grumbach","year":"1964"},{"key":"S0016672300010053_ref007","first-page":"223","article-title":"The molars of the tabby mouse, and a test of the \u2018single-active X-chromosome\u2019 hypothesis","volume":"15","author":"Gr\u00fcneberg","year":"1966","journal-title":"J. Embryol. exp. Morph."},{"key":"S0016672300010053_ref009","doi-asserted-by":"publisher","DOI":"10.1159\/000129857"},{"key":"S0016672300010053_ref011","first-page":"135","article-title":"Sex chromatin and gene action in the mammalian X-chromosome","volume":"14","author":"Lyon","year":"1962","journal-title":"Am. J. hum. Genet."},{"key":"S0016672300010053_ref012","first-page":"67","volume-title":"Second International Conference on Congenital Malformations","author":"Lyon","year":"1964"},{"key":"S0016672300010053_ref013","volume-title":"Advances in Teratology","author":"Lyon","year":"1966"},{"key":"S0016672300010053_ref015","doi-asserted-by":"publisher","DOI":"10.1159\/000129820"},{"key":"S0016672300010053_ref017","doi-asserted-by":"publisher","DOI":"10.1126\/science.140.3570.976"},{"key":"S0016672300010053_ref010","volume-title":"The Nature and Origin of X-chromosome Aberrations in Turner's Syndrome","author":"Lindsten","year":"1963"}],"container-title":["Genetical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0016672300010053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T22:54:12Z","timestamp":1633906452000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0016672300010053\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,9]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1966,9]]}},"alternative-id":["S0016672300010053"],"URL":"https:\/\/doi.org\/10.1017\/s0016672300010053","relation":{},"ISSN":["0016-6723","1469-5073"],"issn-type":[{"value":"0016-6723","type":"print"},{"value":"1469-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,9]]}}}