{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:40:29Z","timestamp":1777621229822,"version":"3.51.4"},"reference-count":19,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"unspecified","delay-in-days":15475,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[1966,12]]},"abstract":"<jats:p>1. Nude is a new recessive gene causing hairlessness in the mouse. It is linked to rex and trembler in linkage group VII. The order of the three loci and the recombination frequencies are as follows:<\/jats:p><jats:p><jats:disp-formula><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mime-subtype=\"gif\" mimetype=\"image\" position=\"float\" xlink:type=\"simple\" xlink:href=\"S0016672300010168_eqnU1\"\/><\/jats:disp-formula><\/jats:p><jats:p>2. In addition to hairlessness the new gene causes reduced body growth rate, very low fertility and a liver disease causing death. Nude mice may be classified at birth by the absence of vibrissae.<\/jats:p><jats:p>3. The hairlessness is due to abnormal keratinization of hair in the follicles. The skin histology resembles that of naked mice. The hair follicles were found to be deficient in free sulphydryl groups.<\/jats:p><jats:p>4. The majority of nude mice die of general body weakness within 2 weeks of birth. The survivors grow slowly and may live for a considerable period. But all nude mice eventually die, usually between 3 and 14 weeks of age.<\/jats:p><jats:p>5. The livers of dead or moribund nude mice are covered with lesions and scars. The defect has been traced histologically to its initial stage, namely, necrosis of small areas of tissue.<\/jats:p><jats:p>6. Attempts to relate the deficiency of sulphydryl groups in the hair follicles to abnormal sulphur metabolism in the liver were unsuccessful.<\/jats:p><jats:p>7. Pseudo-cysts of a parasitic protozoan,<jats:italic>Toxoplasma gondii<\/jats:italic>, were identified in the liver and brain of nude mice. In one case the free form of the organism was found.<\/jats:p><jats:p>8. The possible relationship between the liver disease and the pathogenic organism is discussed.<\/jats:p>","DOI":"10.1017\/s0016672300010168","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T07:57:56Z","timestamp":1253174276000},"page":"295-309","source":"Crossref","is-referenced-by-count":646,"title":["\u2018Nude\u2019, a new hairless gene with pleiotropic effects in the mouse"],"prefix":"10.1155","volume":"8","author":[{"given":"S. P.","family":"Flanagan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"S0016672300010168_ref006","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a106383"},{"key":"S0016672300010168_ref003","doi-asserted-by":"publisher","DOI":"10.1007\/BF00584618"},{"key":"S0016672300010168_ref011","first-page":"326","article-title":"Pathological states due to deficiency of the sulphur containing amino acids","volume":"26","author":"Glynn","year":"1945","journal-title":"Br. J. exp. Path."},{"key":"S0016672300010168_ref002","doi-asserted-by":"publisher","DOI":"10.1007\/BF02996226"},{"key":"S0016672300010168_ref004","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/14.2.341"},{"key":"S0016672300010168_ref010","first-page":"1","article-title":"La keratinization de l'epiderme et de phanares. Genesa des substances soufrees de la keratins","volume":"29","author":"Giroud","year":"1930","journal-title":"Archs. Morph. gin. exp."},{"key":"S0016672300010168_ref008","doi-asserted-by":"publisher","DOI":"10.1139\/cjr46d-002"},{"key":"S0016672300010168_ref019","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.06.100152.001433"},{"key":"S0016672300010168_ref005","doi-asserted-by":"publisher","DOI":"10.1007\/BF02996227"},{"key":"S0016672300010168_ref015","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1952.29"},{"key":"S0016672300010168_ref017","first-page":"65","article-title":"Investigations into the distribution of thiol groups in the skin follicles of mice and sheep and the entry of labelled sulphur compounds","volume":"LXVII","author":"Ryder","year":"1958","journal-title":"Proc. B. Soc. Edinb."},{"key":"S0016672300010168_ref016","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/genetics\/34.6.708","article-title":"Analysis of pleiotropism of the W locus in the mouse; relationship between the effects of W and Wv substitution on hair pigmentation and on erythrocytes","volume":"34","author":"Russell","year":"1949","journal-title":"Genetics"},{"key":"S0016672300010168_ref018","doi-asserted-by":"publisher","DOI":"10.1007\/BF02981618"},{"key":"S0016672300010168_ref007","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1953.2.420"},{"key":"S0016672300010168_ref009","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1953.2.390"},{"key":"S0016672300010168_ref012","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982770"},{"key":"S0016672300010168_ref001","first-page":"231","article-title":"The demonstration of thiol groups in certain tissues by means of a new coloured sulphydryl reagent","volume":"110","author":"Bennett","year":"1951","journal-title":"Anat. Bee."},{"key":"S0016672300010168_ref013","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1953.2.365"},{"key":"S0016672300010168_ref014","volume-title":"Biochemists Handbook","author":"Long","year":"1961"}],"container-title":["Genetical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0016672300010168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T22:54:04Z","timestamp":1633906444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0016672300010168\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,12]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1966,12]]}},"alternative-id":["S0016672300010168"],"URL":"https:\/\/doi.org\/10.1017\/s0016672300010168","relation":{},"ISSN":["0016-6723","1469-5073"],"issn-type":[{"value":"0016-6723","type":"print"},{"value":"1469-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,12]]}}}