{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:42:44Z","timestamp":1766266964360},"reference-count":11,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"unspecified","delay-in-days":14744,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[1968,12]]},"abstract":"<jats:p>1. The comparison of the dry weight of thin layer haploid and diploid colonies of<jats:italic>A. niger<\/jats:italic>on complete medium and complete medium supplemented with<jats:italic>p<\/jats:italic>-fluoro-phenylalanine led to the conclusion that there is a difference in growth rates of hyphae under these different conditions.<\/jats:p><jats:p>2. The growth curves of the same strains on both media were established. On complete medium, haploids and diploid show a growth rate increasing linearly for about 20 h after germination and reaching a maximum which is then maintained. On<jats:italic>p<\/jats:italic>-fluorophenylalanine, the haploids show a similar curve, although the maximum growth rate reached and maintained is about half that on complete medium; for the diploid, however, the maximum is less than the corresponding one in the haploid and, once this maximum has been reached, the growth rate goes down linearly to a very low value which is then maintained.<\/jats:p><jats:p>3. The cytological study of the hyphal tip cell showed, in the presence of the amino acid analogue, a reduction of the mean size of the diploid nuclei together with an increase of the number of nuclear fragments. This explains the growth rates observed and is accepted as a confirmation that<jats:italic>p<\/jats:italic>-fluorophenylalanine, by its action on the mitosis, favours chromosome losses which lead finally to the production of haploid nuclei.<\/jats:p>","DOI":"10.1017\/s0016672300011897","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T07:55:37Z","timestamp":1253174137000},"page":"305-315","source":"Crossref","is-referenced-by-count":18,"title":["Growth rate and haploidization of<i>Aspergillus niger<\/i>on medium containing<i>p<\/i>-fluorophenylalanine"],"prefix":"10.1155","volume":"12","author":[{"given":"Pol","family":"Lhoas","sequence":"first","affiliation":[]}],"member":"98","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"S0016672300011897_ref011","volume-title":"Analysis of Variance and Covariance","author":"Snedecor","year":"1934"},{"key":"S0016672300011897_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300009605"},{"key":"S0016672300011897_ref008","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0065-2660(08)60408-3","article-title":"The genetics of Aspergillus nidulans","volume":"5","author":"Pontecorvo","year":"1953","journal-title":"Adv. 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Butt."},{"key":"S0016672300011897_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300011204"},{"key":"S0016672300011897_ref004","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/genetics\/46.12.1581","article-title":"The process of spontaneous recombination in vegetative nuclei of Asper-gillus nidulans","volume":"46","author":"K\u00e4fer","year":"1961","journal-title":"Genetics"},{"key":"S0016672300011897_ref005","doi-asserted-by":"publisher","DOI":"10.1038\/190744a0"},{"key":"S0016672300011897_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300004249"},{"key":"S0016672300011897_ref009","doi-asserted-by":"publisher","DOI":"10.1007\/BF02168881"},{"key":"S0016672300011897_ref010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.1924.tb06621.x"},{"key":"S0016672300011897_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300010752"}],"container-title":["Genetical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0016672300011897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T22:53:22Z","timestamp":1633906402000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0016672300011897\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,12]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1968,12]]}},"alternative-id":["S0016672300011897"],"URL":"https:\/\/doi.org\/10.1017\/s0016672300011897","relation":{},"ISSN":["0016-6723","1469-5073"],"issn-type":[{"value":"0016-6723","type":"print"},{"value":"1469-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,12]]}}}