{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T00:21:23Z","timestamp":1705105283405},"reference-count":20,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"unspecified","delay-in-days":12736,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[1974,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The<jats:italic>p<\/jats:italic><jats:sup>6H<\/jats:sup>,<jats:italic>p<\/jats:italic><jats:sup>25H<\/jats:sup>, and<jats:italic>p<jats:sup>bs<\/jats:sup><\/jats:italic>alleles at the pink-eyed dilution locus in mice (<jats:italic>Mus musculus<\/jats:italic>) cause sterility in males and semi-fertility in females when homozygous, while the<jats:italic>p<jats:sup>d<\/jats:sup>, p<jats:sup>un<\/jats:sup>, p<\/jats:italic>, and + alleles do not reduce fertility. Pituitaries from sterile males had significantly lower proportions of gonadotropic cells than pituitaries from fertile males. Ovaries from semi-fertile females contained large numbers of developing follicles, but no corpora lutea or corpora hemorrhagica were found. The proportion of polyovular follicles in ovaries of semifertile females was abnormally high.<\/jats:p><jats:p>Pituitary gonadotropins appear to be reduced in the sterile genotypes although the lesion cannot be localized. Possible relationships between these and other pleiotropic effects of mutant<jats:italic>p<\/jats:italic>-alleles are discussed.<\/jats:p>","DOI":"10.1017\/s0016672300014956","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T07:49:24Z","timestamp":1253173764000},"page":"319-325","source":"Crossref","is-referenced-by-count":6,"title":["The effects of mutant<i>p<\/i>-alleles on the reproductive system in mice"],"prefix":"10.1155","volume":"23","author":[{"given":"Roger W.","family":"Melvold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"S0016672300014956_ref010","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/icb\/6.1.43","article-title":"Genetic variations in the fine structure and ontogeny of mouse melanin granules","volume":"6","author":"Moyer","year":"1966","journal-title":"American Zoologist"},{"key":"S0016672300014956_ref013","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/genetics\/31.3.327","article-title":"A quantitative histological study of the pigment found in the coat-color of the mouse. I. Variable attributes of the pigment granules","volume":"31","author":"Russell","year":"1946","journal-title":"Genetics"},{"key":"S0016672300014956_ref020","first-page":"s298","article-title":"Sterility of mice carrying mutant genes at the pink-eyed dilution locus","volume":"74","author":"Wolfe","year":"1973","journal-title":"Genetics"},{"key":"S0016672300014956_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(65)90023-0"},{"key":"S0016672300014956_ref019","doi-asserted-by":"publisher","DOI":"10.1093\/biolreprod\/4.2.161"},{"key":"S0016672300014956_ref002","first-page":"161","article-title":"Studies of a size cross in mice. II","volume":"2","author":"Castle","year":"1936","journal-title":"Genetics"},{"key":"S0016672300014956_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)33789-X"},{"key":"S0016672300014956_ref004","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/genetics\/45.4.413","article-title":"Pleiotropic effects of a mutant at the p locus from irradiated mice","volume":"45","author":"Hollander","year":"1960","journal-title":"Genetics"},{"key":"S0016672300014956_ref005","first-page":"111","article-title":"Abnormal spermiogenesis in two pink-eyed sterile mutants in the mouse","volume":"26","author":"Hunt","year":"1971","journal-title":"Journal of Embryology and Experimental Morphology"},{"key":"S0016672300014956_ref006","first-page":"52","article-title":"Research note","volume":"47","author":"Johnson","year":"1972","journal-title":"Mouse News Letter"},{"key":"S0016672300014956_ref007","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091370411"},{"key":"S0016672300014956_ref008","unstructured":"Melvold R. W. (1973). Pleiotropic effects of p-alleles in the mouse. Ph.D. thesis, University of Kansas."},{"key":"S0016672300014956_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(71)90036-4"},{"key":"S0016672300014956_ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1963.tb42874.x"},{"key":"S0016672300014956_ref012","first-page":"52","article-title":"Research note","volume":"47","author":"Phillips","year":"1973","journal-title":"Mouse News Letter"},{"key":"S0016672300014956_ref014","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/genetics\/34.2.146","article-title":"A quantitative histological study of the pigment found in the coat-color of the mouse. IV. The nature of the effects of genic substitution in five major allelic series","volume":"34","author":"Russell","year":"1949","journal-title":"Genetics"},{"key":"S0016672300014956_ref011","first-page":"26","article-title":"Research note","volume":"42","author":"Phillips","year":"1970","journal-title":"Mouse News Letter"},{"key":"S0016672300014956_ref016","first-page":"s236","article-title":"Complementation analysis of c locus lethals in the mouse","volume":"74","author":"Russell","year":"1973","journal-title":"Genetics"},{"key":"S0016672300014956_ref018","first-page":"891","article-title":"Three types of chromophilic cells of the adenohypophysis","volume":"30","author":"Wilson","year":"1954","journal-title":"American Journal of Pathology"},{"key":"S0016672300014956_ref001","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1071\/BI9590065","article-title":"Strain differences in the morphology of the gametes of the mouse","volume":"12","author":"Braden","year":"1959","journal-title":"Australian Journal of Biological Science"}],"container-title":["Genetical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0016672300014956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T22:51:07Z","timestamp":1633906267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0016672300014956\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,6]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1974,6]]}},"alternative-id":["S0016672300014956"],"URL":"https:\/\/doi.org\/10.1017\/s0016672300014956","relation":{},"ISSN":["0016-6723","1469-5073"],"issn-type":[{"value":"0016-6723","type":"print"},{"value":"1469-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,6]]}}}